Protective effects of ulinastatin on proliferation and cytokine release of splenocytes from rats with severe acute pancreatitis

European Surgical Research

Volumn 38, Issue 5, 2006, Pages 445-450

  Ma, Tao ^a   Kang, Chunsheng ^a   Shao, Hongwei ^a   Qi, Nghui ^a   Hu, Wenquan ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Acute pancreatitis; Cytokine release; Splenocytes; Ulinastatin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CONCANAVALIN A; CYTOKINE; DEOXYCHOLATE SODIUM; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; PROTEINASE; SODIUM CHLORIDE; ULINASTATIN;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE FUNCTION TEST; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MALE; NONHUMAN; PANCREATITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPLEEN CELL; SUPERNATANT; THERAPY EFFECT; TREATMENT OUTCOME;

ANIMALS; CELL PROLIFERATION; GLYCOPROTEINS; INTERFERON TYPE II; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; MALE; PANCREATITIS; RATS; RATS, WISTAR; SPLEEN; TRYPSIN INHIBITORS;

EID: 33750213832     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095087     Document Type: Article

References (35)

1. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, Chevali L: Pathophysiology of acute pancreatitis. Pancreatology 2005;5:132-144.
2. Pandol SJ: Acute pancreatitis. Curr Opin Gastroenterol 2005;21:538-543.
3. Malangoni MA, Martin AS: Outcome of severe acute pancreatitis. Am J Surg 2005;189:273-277.
4. Takeyama Y: Significance of apoptotic cell death in systemic complications with severe acute pancreatitis. J Gastroenterol 2005;40:1-10.
5. Uehara S, Gothoh K, Handa H, Tomita H, Tomita Y: Immune function in patients with acute pancreatitis. J Gastroenterol Hepatol 2003;18:363-370.
6. Takeyama Y, Takas K, Ueda T, Hori Y, Goshima M, Kuroda Y: Peripheral lymphocyte reduction in severe acute pancreatitis is caused by apoptotic cell death. J Gastrointest Surg 2000;4:379-387.
7. Chen SY, Wang JY; Shanghai Collaboration Group on Ulinastatin Clinical Trials: Ulinastatin in the treatment of acute pancreatitis: a multicenter clinical trial. Chin J Dig Dis 2001;21:293-296.
8. Tsujino T, Komatsu Y, Isayama H, Hirano K, Sasahira N, Yamamoto N, Toda N, Ito Y, Nakai Y, Tada M, Matsumura M, Yoshida H, Kawabe T, Shiratori Y, Omata M: Ulinastatin for pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized, controlled trial. Clin Gastroenterol Hepatol 2005;3:376-383.
9. Molor-Erdene P, Okajima K, Isobe H, Uchiba M, Harada N, Shimozawa N, Okabe H: Inhibition of lipopolysaccharide-induced tissue factor expression in monocytes by urinary trypsin inhibitor in vitro and in vivo. Thromb Haemost 2005;94:136-145.
10. Ito K, Mizutani A, Kira S, Mori M, Iwasaka H, Noguchi T: Effect of ulinastatin, a human urinary trypsin inhibitor, on the oleic acid-induced acute lung injury in rats via the inhibition of activated leukocytes. Injury 2005;36:387-394.
11. Inoue K, Takano H, Shimada A, Yanagisawa R, Sakurai M, Yoshino S, Sato H, Yoshikawa T: Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide. Mol Pharmacol 2005;67:673-680.
12. Sato N, Endo S, Kimura Y, Ikeda K, Aoki K, Iwaya T, Akiyama Y, Noda Y, Saito K: Influence of a human protease inhibitor on surgical stress induced immunosuppression. Dig Surg 2002;19:300-305.
13. Miki S, Takeyama N, Tanaka T, Nakatani T: Immune dysfunction in endotoxicosis: role of nitric oxide produced by inducible nitric oxide synthase. Crit Care Med 2005;33:716-720.
14. Schwacha MG, Holland LT, Chaudry IH, Messina JL: Genetic variability in the immune-inflammatory response after major burn injury. Shock 2005;23:123-128.
15. Matsutani T, Anantha Samy TS, Kang SC, Bland KI, Chaudry IH: Mouse genetic background influences severity of immune responses following trauma-hemorrhage. Cytokine 2005;30:168-176.
16. Yasuda T, Takeyama Y, Ueda T, Takase K, Nishikawa J, Kuroda Y: Splenic atrophy in experimental severe acute pancreatitis. Pancreas 2002;24:365-372.
17. Curley P, Nestor M, Collins K, Saporoschetz I, Mendez M, Mannick JA, Rodrick ML: Decreased interleukin-2 production in murine acute pancreatitis: potential for immunomodulation. Gastroenterology 1996;110:583-588.
18. Shao H, Qi Q: A study on the relationship between acute pancreatitis and apoptosis of the acinar cells. Chin J Gen Surg 2003;18:23-24.
19. Antal L, Szabo G, Sonkoly S, Paloczi K, Szegedi G: Abnormalities in humoral and cellular immunoactivity in pancreatitis. II. Study of the cellular immune system. Acta Med Acad Sci Hung 1978;35:81-87.
20. Christophi C, McDermott F, Hughes ES: Prognostic significance of absolute lymphocyte count in acute pancreatitis. Am J Surg 1985;150:295-296.
21. Ueda T, Takeyama Y, Yasuda T, Takase K, Nishikawa J, Kuroda Y: Functional alterations of splenocytes in severe acute pancreatitis. J Surg Res 2002;102:161-168.
22. Ueda T, Takeyama Y, Kuroda Y: Animal experimental models for acute pancreatitis. Nippon Rinsho 2004;62:1984-1988.
23. Ayala A, Chung CS, Song GY, Chaudry IH: IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis. Cytokine 2001;14:37-48.
24. Guo Z, Kavanagh E, Zang Y, Dolan SM, Kriynovich SJ, Mannick JA, Lederer JA: Burn injury promotes antigen-driven Th2-type responses in vivo. J Immunol 2003;171:3983-3990.
25. Zaitsu M, Hamasaki Y, Tashiro K, Matsuo M, Ichimaru T, Fujita I, Tasaki H, Miyazaki S: Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease. J Infect Dis 2000;181:1101-1109.
26. Okuhama Y, Shiraishi M, Riga T, Tomori H, Taira K, Mamadi T, Muto Y: Protective effects of ulinastatin against ischemia-reperfusion injury. J Surg Res 1999;82:34-42.
27. Inoue K, Takano H, Yanagisawa R, Sakurai M, Shimada A, Yoshino S, Sato H, Yoshikawa T: Protective role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide. Exp Biol Med (Maywood) 2005;230:281-287.
28. Hirano T, Manabe T, Tobe T: Effect of urinary trypsin inhibitor on pancreatic cellular and lysosomal fragility in cerulein-induced acute pancreatitis in rats. Dig Dis Sci 1993;38:660-664.
29. Ohnishi H, Kosuzume H, Ashida Y, Kato K, Honjo I: Effects of urinary trypsin inhibitor on pancreatic enzymes and experimental acute pancreatitis. Dig Dis Sci 1984;29:26-32.
30. Chen H, Zhou H, Fu H: Experimental study on combined use of sodium aescinate and ulinastatin in treatment of acute pancreatitis in rats. Chin J TCM WM Crit Care 2006;13:51-53.
31. Seta T, Noguchi Y, Shimada T, Shikata S, Fukui T: Treatment of acute pancreatitis with protease inhibitors: a meta-analysis. Eur J Gastroenterol Hepatol 2004;16:1287-1293.
32. Bassi C, Falconi M, Caldiron E, Salvia R, Sartori N, Butturini G, Contro C, Marcucci S, Casetti L, Pederzoli P: Assessment and treatment of severe pancreatitis. Protease inhibitor. Digestion 1999;60(suppl 1):5-8.
33. Zhang XQ, Sun JL, Chen YJ, Ma R, Fan XH, Sun JZ: Amelioration of ischemia-reperfusion injury of transplanted small intestine by ulinastatin: effects on accumulation and adhesion of neutrophil. Transplant Proc 2005;37:4464-4466.
34. Yamaguchi Y, Ohshiro H, Nagao Y, Odawara K, Okabe K, Hidaka H, Ishihara K, Uchino S, Furuhashi T, Yamada S, Mori K, Ogawa M: Urinary trypsin inhibitor reduces C-X-C chemokine production in rat liver ischemia/ reperfusion. J Surg Res 2000;94:107-115.
35. Fries E, Blom AM: Bikunin - not just a plasma proteinase inhibitor. Int J Biochem Cell Biol 2000;32:125-137.