Decreased expression of toll-like receptor 2 and 4 on macrophages in experimental severe acute pancreatitis

Kobe Journal of Medical Sciences

Volumn 53, Issue 5, 2007, Pages 219-227

  Matsumura, Naoki ^a   Takeyama, Yoshifumi ^b   Ueda, Takashi ^a   Yasuda, Takeo ^a   Shinzeki, Makoto ^a   Sawa, Hidehiro ^a   Nakajima, Takahiro ^a   Kuroda, Yoshikazu ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Expression; Macrophage; Severe acute pancreatitis; TLR2; TLR4

Indexed keywords

DEOXYCHOLATE SODIUM; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ACUTE HEMORRHAGIC PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; EXPERIMENTAL STUDY; IMMUNOPATHOGENESIS; IMMUNOREGULATION; MACROPHAGE; MALE; NONHUMAN; PANCREAS DUCT; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ACUTE DISEASE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MALE; PANCREATITIS; PROTEIN TRANSPORT; RATS; RATS, WISTAR; RNA, MESSENGER; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 39649114801     PISSN: 00232513     EISSN: 18830498     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Aliprantis, A.O., Yang, R.B., Mark, M.R., Suggett, S., Devaux, B., Radolf, J.D., Klimpel, G.R., Godowski, P., and Zychlinsky, A. 1999. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285:736-739.
2. Beger, H.G., Bittner, R., Block, S., and Buchler, M. 1986. Bacterial contamination of pancreatic necrosis. A prospective clinical study. Gastroenterology 91:433-438.
3. Bosisio, D., Polentarutti, N., Sironi, M., Bernasconi, S., Miyake, K., Webb, G.R., Martin, M.U., Mantovani, A., and Muzio, M. 2002. Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-gamma: a molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 99:3427-3431.
4. Buchler, M.W., Gloor, B., Muller, C.A., Friess, H., Seiler, C.A., and Uhl, W. 2000. Acute necrotizing pancreatitis: treatment strategy according to the status of infection. Ann Surg 232:619-626.
5. Echchannaoui, H., Frei, K., Schnell, C., Leib, S.L., Zimmerli, W., and Landmann, R. 2002. Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis 186:798-806.
6. Gogos, C.A., Drosou, E., Bassaris, H.P., and Skoutelis, A. 2000. Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 181:176-180.
7. Hausmann, M., Kiessling, S., Mestermann, S., Webb, G., Spottl, T., Andus, T., Scholmerich, J., Herfarth, H., Ray, K., Falk, W., and Rogler, G. 2002. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122:1987-2000.
8. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., and Akira, S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752.
9. Ikushima, H., Nishida, T., Takeda, K., Ito, T., Yasuda, T., Yano, M., Akira, S., and Matsuda, H. 2004. Expression of Toll-like receptors 2 and 4 is downregulated after operation. Surgery 135:376-385.
10. Koedel, U., Angele, B., Rupprecht, T., Wagner, H., Roggenkamp, A., Pfister, H.W., and Kirschning, C.J. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170:438-444.
11. Li, Y., Zhou, Z.G., Xia, Q.J., Zhang, J., Li, H.G., Cao, G.Q., Wang, R., Lu, Y.L., and Hu, T.Z. 2005. Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis. Pancreas 30:375-381.
12. Medich, D.S., Lee, T.K., Melhem, M.F., Rowe, M.I., Schraut, W.H., and Lee, K.K. 1993. Pathogenesis of pancreatic sepsis. Am J Surg 165:46-50.
13. Medzhitov, R., Preston-Hurlburt, P., and Janeway, C.A. Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-397.
14. Mita, Y., Dobashi, K., Endou, K., Kawata, T., Shimizu, Y., Nakazawa, T., and Mori, M. 2002. Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4. Immunol Lett 81:71-75.
15. Miyaso, H., Morimoto, Y., Ozaki, M., Haga, S., Shinoura, S., Choda, Y., Iwagaki, H., and Tanaka, N. 2005. Obstructive jaundice increases sensitivity to lipopolysaccharide via TLR4 upregulation: Possible involvement in gut-derived hepatocyte growth factor-protection of hepatocytes. J Gastroenterol Hepatol 20:1859-1866.
16. Ortega-Cava, C.F., Ishihara, S., Rumi, M.A., Kawashima, K., Ishimura, N., Kazumori, H., Udagawa, J., Kadowaki, Y., and Kinoshita, Y. 2003. Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol 170:3977-3985.
17. Pastor, C.M., Pugin, J., Kwak, B., Chanson, M., Mach, F., Hadengue, A., and Frossard, J.L. 2004. Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia. Crit Care Med 32:1759-1763.
18. Poltorak, A., He, X., Smirnova, I., Liu, M.Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088.
19. Roger, T., David, J., Glauser, M.P., and Calandra, T. 2001. MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 414:920-924.
20. Runkel, N.S., Moody, F.G., Smith, G.S., Rodriguez, L.F., LaRocco, M.T., and Miller, T.A. 1991. The role of the gut in the development of sepsis in acute pancreatitis. J Surg Res 51:18-23.
21. Sawa, H., Ueda, T., Takeyama, Y., Yasuda, T., Shinzeki, M., Nakajima, T., and Kuroda, Y. in press. Role of toll-like receptor 4 in the pathophysiology of mice severe acute pancreatitis. Surg Today: in press.
22. Shahin, R.D., Engberg, I., Hagberg, L., and Svanborg Eden, C. 1987. Neutrophil recruitment and bacterial clearance correlated with LPS responsiveness in local gram-negative infection. J Immunol 138:3475-3480.
23. Sweet, M.J., Campbell, C.C., Sester, D.P., Xu, D., McDonald, R.C., Stacey, K.J., Hume, D.A., and Liew, F.Y. 2002. Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J Immunol 168:392-399.
24. Takeda, K., Kaisho, T., and Akira, S. 2003. Toll-like receptors. Annu Rev Immunol 21:335-376.
25. Ueda, T., Takeyama, Y., Yasuda, T., Shinzeki, M., Sawa, H., Nakajima, T., Ajiki, T., Fujino, Y., Suzuki, Y., and Kuroda, Y. 2006. Immunosuppression in patients with severe acute pancreatitis. J Gastroenterol 41:779-784.
26. van Westerloo, D.J., Weijer, S., Bruno, M.J., de Vos, A.F., Van't Veer, C., and van der Poll, T. 2005. Toll-like receptor 4 deficiency and acute pancreatitis act similarly in reducing host defense during murine Escherichia coli peritonitis. Crit Care Med 33:1036-1043.
27. Williams, D.L., Ha, T., Li, C., Kalbfleisch, J.H., Schweitzer, J,, Vogt, W., and Browder, I.W. 2003. Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit Care Med 31:1808-1818.
28. Woods, J.P., Frelinger, J.A., Warrack, G., and Cannon, J.G. 1988. Mouse genetic locus Lps influences susceptibility to Neisseria meningitidis infection. Infect Immun 56:1950-1955.
29. Wu, H.S., Zhang, L., Chen, Y., Guo, X.J., Wang, L., Xu, J.B., Wang, C.Y., and Zhang, J.H. 2005. Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis. Hepatobiliary Pancreat Dis Int 4:609-613.
30. Yoshimura, A., Lien, E., Ingalls, R.R., Tuomanen, E., Dziarski, R., and Golenbock, D. 1999. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol 163:1-5.
31. Zhang, L., Wu, H.S., Chen, Y., Guo, X.J., Wang, L., Wang, C.Y., Zhang, J.H., and Tian, Y. 2006. Role of nitric oxide in Toll-like receptor 2 and 4 mRNA expression in liver of acute hemorrhagic necrotizing pancreatitis rats. World J Gastroenterol 12:485-488.