IL-10 mediation of activation-induced Th1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis

Cytokine

Volumn 14, Issue 1, 2001, Pages 37-48

  Ayala, Alfred ^a   Chung, Chun Shiang ^a   Song, Grace Y ^a   Chaudry, Irshad H ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Apoptosis; CD4; Fas; FasL; IL 2; IL l0; Mice; Sepsis; T lymphocytes; Th1 and Th2

Indexed keywords

CYTOKINE RECEPTOR; GAMMA INTERFERON; GENE PRODUCT; IBUPROFEN; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 4 ANTIBODY; MONOCLONAL ANTIBODY; PROSTAGLANDIN E2; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; IMMUNE SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOID CELL; MALE; MORBIDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SEPSIS; SIGNAL TRANSDUCTION; SPLEEN CELL; TH1 CELL;

ANIMALIA;

EID: 0035820181     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2001.0848     Document Type: Article

References (63)

1. Apoptosis and programmed cell death in immunity
2. Programmed cell death, apoptosis and killer genes
3. Fas and FasL in the homeostatic regulation of immune responses
4. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes
5. The induction of accelerated thymic programmed cell death during polymicrobial sepsis: Control by corticosteroids but not tumor necrosis factor
6. Differential induction of apoptosis in lymphoid tissues during sepsis: Variation in onset, frequency, and the nature of the mediators
7. Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin mediated process
8. Sepsis induces increased apoptosis in lamina propria mononuclear cells which is associated with altered cytokine gene expression
9. Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis?
10. Increased inducible apoptosis in CD4+ T-lymphocytes during polymicrobial sepsis is mediated by Fas ligand (FasL) and not endotoxin
11. + T cells from HIV-infected persons
12. + donors by cysteine protease inhibitors
13. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein
14. Anergy, IFNgamma production, and apoptosis in terminal infection of mice with Mycobacterium avium
15. Immune deficiency following thermal trauma is associated with apoptotic cell death
16. Administration to mouse of endotoxin from gram-negative bacteria leads to activation and apoptosis of T lymphocytes
17. Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophage to release inflammatory mediators (IL-1, IL-6 and TNF)
18. LPS plasma levels in patients
19. Endotoxemia in human septic shock
20. Polymicrobial sepsis but not low dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production
21. The complex pattern of cytokines in sepsis - Association between prostaglandins, cachectin and interleukins
22. Role of Ca2+ in prostaglandin E2-induced T-lymphocyte proliferative suppression in sepsis
23. What is IL-10's role in polymicrobial sepsis: Anti-inflammatory agent or immune suppressant?
24. Effect of pharmacological agents on the production of interleukin-10 by the murine D10.G4.1 Th2 cell line in vitro
25. Mechanism of enhanced susceptibility to sepsis following hemorrhage
26. Anti-interleukin-10 antibody restores burn-induced defects in T-cell function
27. Dominance of T-helper 2-type cytokines after severe injury
28. IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense
29. T-cell reactivity and its predictive role in immunesuppression after burns
30. Mechanism of enhanced susceptibility to sepsis following hemorrhage: Interleukin (IL)-10 suppression of T-cell response is mediated by eicosanoid induced IL-4 release
31. Splenic immune suppression in sepsis: A role for IL-10 induced changes in P38 MAPK signaling
32. 2) in traumatized individuals
33. Immunoprotective effects of cyclooxygenase inhibition in patients with major surgical trauma
34. Stroke-damaged neurons may commit cellular suicide
35. Cerebral ischemia enhances polyamine oxidation: Identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death
36. Caspase-3 dependent organ apoptosis early after burn injury
37. Apoptosis in lymphoid and parenchymal cells during sepsis, findings in normal and T and B cell deficient mice
38. Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway
39. Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry
40. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies
41. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin-10 in interferon-gamma and interleukin-4-expressing cells
42. The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylcoccal enterotoxin B
43. Interleukin-10 rescues T cells from apototic cell death: Association with upregulation of Bcl-2
44. A role for T-helper type-1 and type-2 cytokines in the regulation of human monocyte apoptosis
45. Immune depression in polymicrobial sepsis: The role of necrotic (injured) tissue and endotoxin
46. Animal models of sepsis and shock: A review and lessons learned
47. Laboratory models of sepsis and septic shock
48. Interleukin-10 promotes activation induced cell death of SLE lymphocytes mediated by Fas ligand
49. Fas ligand-mediated exocrinopathy resembling Sjogren's syndrome in mice transgenic for IL-10
50. Interleukin-10-mediated T cell apoptosis during the the T helper type 2 cytokine response in murine Schistosoma mansoni parasite infection
51. Type 1 and type 2 cytokines in HIV infection - A possible role for apoptosis and disease progression
52. Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis
53. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
54. Toll-like receptor 4 (TLR4)-deficient mice are hypresponsive to lipopolysaccharide: Evidence for TLR4 as Lps gene product
55. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
56. Prevention of lymphocyte cell death in sepsis improves survival in mice
57. Apoptotic cell death in patients with sepsis, shock and multiple organ dysfunction
58. Interleukin-10-deficient mice develop chronic enterocolitis
59. Evaluation of factors affecting mortality rate after sepsis in murine cecal ligation and puncture model
60. Does hepatocellular injury in sepsis involve apoptosis?
61. A sensitive and specific bioassay for the detection of human interleukin-10
62. Fine specificity of antigen recognition by T cell hybridoma clones specific for poly-18: A synthetic polypeptide antigen of defined sequence and confirmation
63. A novel gene product that couples TCR signaling to Fas(CD95) expression in activation-induced cell death