Molecular Palaeopathology of Human Infectious Disease

Advances in Human Palaeopathology

Volumn , Issue , 2007, Pages 147-176

  Donoghue, Helen D ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b The Universities of Zambia   (United Kingdom)

Author keywords

Leprosy; Microbial genomics; Palaeomicrobiology; Palaeoparasitology; Plague; Tuberculosis

Indexed keywords

EID: 67650595577     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470724187.ch8     Document Type: Chapter

References (169)

1. Abu Al-Soud W, Rådström P. 2000. Effects of amplification facilitators on diagnostic PCR in the presence of blood, feces and meat. J Clin Microbiol 38: 4463-4470.
2. Achtman M. Zurth K, Morelli G, Guiyoule A, Carniel E. 1999. Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis. Proc Natl Acad Sci USA 96: 14043-14048.
3. Adamson PB. 1976. Schistosomiasis in antiquity. Med Hist 20: 176-188.
4. Araújo A, Ferreira LF. 2000. Paleoparasitology and the antiquity of human host-parasite relationships. Mem Inst Oswaldo Cruz 95(Suppl 1): 89-93.
5. Armelagos GJ, Brown PJ, Turner B. 2005. Evolutionary, historical and political economic perspectives on health and disease. Soc Sci Med 61: 755-765.
6. Aufderheide AC, Salo W, Madden M, Streitz J, Buikstra J, et al. 2004. A 9,000-year record of Chagas' disease. Proc Natl Acad SciUSA 101: 2034-2039.
7. Baker L, Brown T, Maiden MC, Drobniewski F. 2004. Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis. Emerg Inf Dis 10: 1568-1577.
8. Barnes I, Thomas MG. 2006. Evaluating bacterial pathogen DNA preservation in museum osteological collections. Proc RSocB 273: 635-653.
9. Barnes I, Holton J, Vaira D, Spigelman M, Thomas MG. 2000. An assessment of the long-term preservation of the DNA of a bacterial pathogen in ethanol-preserved archival material. J Pathol 192: 554-559.
10. Boom R, Sol CJA, Salimans MMM, Jansen CL, Wertheim-van Dillen PME, van der Noordaa J. 1990. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 28: 495-503.
11. Bouwman AS, Brown TA. 2005. The limits of biomolecular palaeopathology: ancient DNA cannot be used to study venereal syphilis. J Archaeol Sci 32: 703-713.
12. Bouwman AS, Chilvers ER, Brown KA, Brown TA. 2006. Brief communication: identification of the authentic ancient DNA sequence in a human bone contaminated with modern DNA. Am J Phys Anthropol 131: 428-431.
13. Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, et al. 2002. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc Natl Acad SciUSA 99: 3684-3689.
14. Brubaker ML, Meyers WM, Bourland J. 1985. Leprosy in children one year of age and under. Int J Lepr Other Mycobact Dis 53: 517-523.
15. Cano RJ, Tiefenbrunner F, Ubaldi M, Del Cueto C, Luciani S, et al. 2000. Sequence analysis of bacterial DNA in the colon and stomach of the Tyrolean Iceman. Am J Phys Anthropol 112: 297-309.
16. Carter R, Mendis KN. 2002. Evolutionary and historical aspects of the burden of malaria. Clin Microbiol Rev 15: 564-594.
17. Cerutti N, Marin A, Massa ER, Savoia D. 1999. Immunological investigations of malaria and new perspectives in palaeopathological studies. Boll Soc Ital Biol Sper 75: 17-20.
18. Cerutti N, Santovito A, Turina M, Crobu F, Rabino Massa E. 2005. Detection of Plasmodium falciparum ancient DNA in Egyptian mummies. J Biol Res 80: 88-90.
19. Chain PS, Carniel E, Larimer FW, Lamerdin J, Stoutland PO, et al. 2004. Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis. Proc Natl Acad SciUSA 101: 13 826-13 831.
20. Cipollaro M, Galderisi U, Di Bernardo G. 2005. Ancient DNA as a multidisciplinary experience. J Cell Physiol 202: 315-322.
21. Cockburn TA. 1971. Infectious diseases in ancient populations. Curr Anthropol 12: 45-62.
22. Cohen MN, Armelagos GJ. 1984. Paleopathology at the origins of agriculture: editor's summation. In Paleopathology at the Origins of Agriculture, Cohen MN, Armelagos GJ (eds). Academic Press: Orlando, FL; 585-601.
23. Cohn Jr SK, Weaver LT. 2006. The Black Death and AIDS: CCR5-32 in genetics and history. QJ Med 99: 497-503.
24. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, et al. 2001. Massive gene decay in the leprosy bacillus. Nature 409: 1007-1011.
25. Collins MJ, Nielsen-Marsh CM, Hiller J, Smith CI, Roberts JP, et al. 2002. The survival of organic matter in bone: a review. Archaeometry 44: 383-394.
26. Dagan T, Blekhman R, Graur D. 2006. The 'domino theory' of gene death: gradual and mass gene extinction events in three lineages of obligate symbiotic bacterial pathogens. Mol Biol Evol 23: 310-316.
27. Deelder AM, Miller RL, de Jonge N, Krijger FW. 1990. Detection of schistosome antigen in mummies. Lancet 335: 724-725.
28. Di Bernando G, Del Gaudio S, Cammarota M, Galderisi U, Cascino A, et al. 2002. Enzymatic repair of selected cross-linked homoduplex molecules enhances nuclear gene rescue from Pompeii and Herculaneum remains. Nucleic Acids Res 30: e16.
29. Donoghue HD, Spigelman M. 2006. Comment. Pathogenic microbial ancient DNA: a problem or an opportunity? Proc R Soc B 273: 641-642.
30. Donoghue HD, Spigelman M, Zias J, Gernaey-Child AM, Minnikin DE. 1998. Mycobacterium tuberculosis complex DNA in calcified pleura from remains 1400 years old. Lett Appl Microbiol 27: 265-269.
31. Donoghue HD, Holton J, Spigelman M. 2001. PCR primers that can detect low levels of Mycobacterium leprae DNA. J Med Microbiol 50: 177-182.
32. Donoghue HD, Gladkowska-Rzeczycka J, Marcsik A, Holton J, Spigelman M. 2002. Mycobacterium leprae in archaeological specimens. In The Past and Present of Leprosy, Roberts CA, Lewis ME, Manchester K (eds). British Archaeological Reports, BAR International Series 1054. Archaeopress: Oxford; 271-285.
33. Donoghue HD, Spigelman M, Greenblatt CL, Lev-Maor G, Bar-Gal GK, et al. 2004. Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA. Lancet Infect Dis 4: 584-592.
34. Donoghue HD, Erdal YS, Pinhasi R, Spigelman M. 2005a. A possible case of congenital leprosy in a 5-month-old child from Byzantine-Age Turkey. In Proceedings of the 26th Annual Congress of the European Society of Mycobacteriology, Istanbul, Turkey, 26-29 June; 177.
35. Donoghue HD, Marcsik A, Matheson C, Vernon K, Nuorala E, et al. 2005b. Coinfection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosy. Proc R Soc B 272: 389-394.
36. Donoghue HD, Matheson CD, David AR, Spigelman M. 2007a. Schistosoma haematobium, Schistosoma mansoni and family relationship in two Egyptian mummies. In VIth World Congress on Mummy Studies, Teguise, Lanzerote, Canary Islands, Spain, 20-24 February (presentation 71).
37. Donoghue HD, Spigelman M, Grant P, Klein A, Shouval D, et al. 2007b. Microbiological investigation of a Korean medieval child mummy found in Yangju. In VIth World Congress on Mummy Studies, Teguise, Lanzerote, Canary Islands, Spain, 20-24 February (presentation 126).
38. Drancourt M, Raoult D. 2004. Molecular detection of Yersinia pestis in dental pulp. Microbiology 150: 263-264.
39. Drancourt M, Raoult D. 2005. Palaeomicrobiology: current issues and perspectives. Nat Rev Microbiol 3: 23-35.
40. Drancourt M, Aboudharam G, Signoli M, Dutour O, Raoult D. 1998. Detection of 400-year-old Yersinia pestis DNA in human dental pulp: an approach to the diagnosis of ancient septicemia. Proc Natl Acad SciUSA 95: 12 637-12 640.
41. Drancourt M, Roux V, Dang LV, Tran-Hung L, Castex D, et al. 2004. Genotyping, Orientalis-like Yersinia pestis, and plague pandemics. Emerg Infect Dis 10: 1585-1592.
42. Drancourt M, Tran-Hung L, Courtin J, Lumley H, Raoult D. 2005. Bartonella quintana in a 4000year-old human tooth. J Infect Dis 191: 607-611.
43. Drancourt M, Signoli M, Dang LV, Bizot B, Roux V, et al. 2007. Yersinia pestis Orientalis in remains of ancient plague victims. Emerg Infect Dis 13: 332-333.
44. Duncan CJ, Scott S. 2006. What caused the Black Death? Postgrad Med J 81: 315-320.
45. Elston DM. 2006. The hygiene hypothesis and atopy: bring back the parasites? J Am Acad Dermatol 54: 172-179.
46. Faerman M, Jankauskas R, Gorski A, Bercovier H, Greenblatt CL. 1997. Prevalence of human tuberculosis in a medieval population of Lithuania studied by ancient DNA analysis. Ancient Biomol 1: 205-214.
47. Fernando SL, Britton WJ. 2006. Genetic susceptibility to mycobacterial disease in humans. Immunol Cell Biol 84: 125-137.
48. Fletcher HA, Donoghue HD, Holton J, Pap I, Spigelman M. 2003a. Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians. Am J Phys Anthropol 120: 144-152.
49. Fletcher HA, Donoghue HD, Taylor M, van der Zanden, Spigelman M. 2003b. Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. Microbiology 149: 143-151.
50. Frothingham R. 1999. Evolutionary bottlenecks in the agents of tuberculosis, leprosy and paratuberculosis. Med Hypotheses 52: 95-99.
51. Gagneux S, DeRiemer K, Van T, Kato-Maeda M, de Jong BC, et al. 2006. Variable host-pathogen compatibility in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 103: 2869-2873.
52. Gernaey AM, Minnikin DE, Copley MS, Power JJ, Ahmed AMS, et al. 1998. Detecting ancient tuberculosis. Internet Archaeol 5: http://intarch.ac.uk/journal/issue5/gernaey_index.html.
53. Gernaey AM, Minnikin DE, Copley MS, Dixon RA, Middleton JC, et al. 2001. Mycolic acids and ancient DNA confirm an osteological diagnosis of tuberculosis. Tuberculosis (Edinb) 81: 259-265.
54. Gilbert MTP, Willerslev E, Hansen AJ, Barnes I, Rudbeck L, et al. 2003. Distribution patterns of postmortem damage in human mitochondrial DNA. Am J Hum Genet 72: 32-47. Erratum: Am J Hum Genet 72: 779.
55. Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, et al. 2004a. Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims. Microbiology 150: 341-354.
56. Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, et al. 2004b. Response to Drancourt and Raoult. Microbiology 150: 264-265.
57. Gilbert MTP, Bandelt H-J, Hofreiter M, Barnes I. 2005a. Assessing ancient DNA studies. Trends Ecol Evol 20: 541-544.
58. Gilbert MTP, Barnes I, Collins MJ, Smith C, Eklund J, et al. 2005b. Long-term survival of ancient DNA in Egypt: response to Zink and Nerlich (2003). Am J Phys Anthropol 128: 110-114.
59. Gilbert MTP, Hansen AJ, Willerslev E, Turner-Walker G, Collins M. 2006. Insights into the processes behind the contamination of degraded human teeth and bone samples with exogenous sources of DNA. Int J Osteoarchaeol 16: 156-164.
60. Gonçalves MLC, Araújo A, Ferreira LF. 2003. Human intestinal parasites in the past: new findings and a review. Mem Inst Oswaldo Cruz 95(Suppl 1): 103-118.
61. Gonçalves MLC, da Silva VL, de Andrade CM, Reinhard K, da Rocha GC, et al. 2004. Amoebiasis distribution in the past: first steps using an immunoassay technique. Trans R Soc Trop Med Hyg 98: 88-91.
62. Götherström A, Fischer C, Lindén K, Lidén K. 1995. X-raying ancient bone: a destructive method in connection with DNA analysis. Laborativ Arkeologi 8: 26-28.
63. Götherström A, Collins MJ, Angerbjörn, Lidén K. 2002. Bone preservation and DNA amplification. Archaeometry 44: 395-404.
64. Grange JM. 1995. Human aspects of Mycobacterium bovis infection. In Mycobacterium bovis Infection in Animals and Humans, Thoen CO, Steele JH (eds). Iowa State University Press: Ames: IA; 29-46.
65. Greenblatt C, Spigelman M (eds). 2003. Emerging Pathogens: Archaeology, Ecology and Evolution of Infectious Disease. Oxford University Press: Oxford.
66. Groathouse NA, Brown SE, Knudson DL, Brennan PJ, Slayden RA. 2006. Isothermal amplification and molecular typing of the obligate intracellular pathogen Mycobacterium leprae from tissues of unknown origin. J Clin Microbiol 44: 1502-1508.
67. Groisman EA, Casadesús J. 2005. The origin and evolution of human pathogens. Mol Microbiol 56: 1-7.
68. Gutierrez MC, Brisse S, Brosch R, Fabre M, Omais B, et al. 2005. Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis. PLoS Pathog 1: 55-61.
69. Haas CJ, Zink A, Pálfi G, Szeimies U, Nerlich AG. 2000. Detection of leprosy in ancient human skeletal remains by molecular detection of Mycobacterium leprae. Am J Clin Pathol 114: 428-436.
70. Haas CJ, Zink A, Szeimies U, Nerlich AG. 2002. Molecular evidence of Mycobacterium leprae in historic bone samples from south Germany. In The Past and Present of Leprosy, Roberts CA, Lewis ME, Manchester K (eds). British Archaeological Reports, BAR International Series 1054. Archaeopress: Oxford; 287-292.
71. Hänni C, Brousseau T, Laudet V, Stehelin D. 1995. Isopropanol precipitation removes PCR inhibitors from ancient bone extracts. Nucleic Acids Res 23: 881-882.
72. Hershkovitz I, Spiers M, Katznelson A, Arensberg B. 1992. Unusual pathological conditions in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol 88: 23-26.
73. Hershkovitz I, Spiers M, Arensberg B. 1993. Leprosy or Madura foot? The ambiguous nature of infectious disease in paleopathology: reply to Dr Manchester. Am J Phys Anthropol 91: 251-253.
74. Higuchi R, Bowman B, Freiberger M, Ryder OA, Wilson AC. 1984. DNA sequences from the quagga, an extinct member of the horse family. Nature 312: 282-284.
75. Hirsh AE, Tsolaki AG, DeRiemer K, Feldman MW, Small PM. 2004. Stable association between strains of Mycobacterium tuberculosis and their human host populations. Proc Natl Acad Sci USA 101: 4871-4876.
76. Hofreiter M, Jaenicke V, Serre D, Haeseler AvA, Pääbo S. 2001a. DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA. Nucleic Acids Res 29: 4793-4799.
77. Hofreiter M, Serre D, Poinar HN, Kuch M, Pääbo S. 2001b. Ancient DNA. Nat Rev Genet 2: 353-359.
78. Höss M, Pääbo S. 1993. DNA extraction from Pleistocene bones by a silica-based purification method. Nucleic Acids Res 21: 3913-3914.
79. Iñiguez AM, Araújo A, Ferreira LF, Vicente ACP. 2003. Analysis of ancient DNA from coprolites: a perspective with random amplified polymorphic DNA-polymerase chain reaction approach. Mem Inst Oswaldo Cruz 98(Suppl 1): 63-65.
80. Jongwutiwes S, Putaporntip C, Iwasaki T, Ferreira MU, Kanbara H, et al. 2005. Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax. Mol Biol Evol 22: 1733-1739.
81. Kamerbeek J, Schouls L, Kolk A, van Agterveld M, van Soolingen D, et al. 1997. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol 35: 907-914.
82. Kemp BM, Smith DG. 2005. Use of bleach to eliminate contaminating DNA from the surface of bones and teeth. Forensic Sci Int 154: 53-61.
83. Kemp BM, Monroe C, Smith DG. 2006. Repeat silica extraction: a simple technique for the removal of PCR inhibitors from DNA extracts. J Archaeol Sci 33: 1680-1689.
84. Kolman CJ, Centurion-Lara A, Lukehart SA, Owsley DW, Tuross N. 1999. Identification of Treponema pallidum subspecies pallidum in a 200-year-old skeletal specimen. J Infect Dis 180: 2060-2063.
85. Larcombe LA, Nickerson P, Hoppa RD, Matheson C. 2005. Detection of a single nucleotide polymorphism in the IL-6 promoter region of ancient nuclear DNA. Infect Genet Evol 5: 117-122.
86. Lewis ME. 2002. Infant and childhood leprosy: present and past. In The Past and Present of Leprosy, Roberts CA, Lewis ME, Manchester K (eds). British Archaeological Reports, BAR International Series 1054. Archaeopress: Oxford; 163-170.
87. Li X, Kolltveit KM, Tronstad L, Olsen I. 2000. Sytemic diseases caused by oral infection. Clin Microbiol Rev 13: 547-558.
88. Likovsky J, Urbanová M, Hájek M, Cerny V, Cech P. 2006. Two cases of leprosy from Zatec (Bohemia) dated to the turn of the 12th century and confirmed by DNA analysis for Mycobacterium leprae. J Archaeol Sci 33: 1276-1283.
89. Lowenstein EJ. 2004. Paleodermatoses: lessons learned from mummies. J Am Acad Dermatol 50: 919-936.
90. Manchester K. 1993. Unusual pathological condition in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol 91: 249-250.
91. Mark L, Patonai Z, Molnar E, Marcsik A. 2006. High-throughput mass spectroscopic determination of ancient pathological biomarkers. In 16th Paleopathology Association European Meeting, Santorini, Greece, 28 August-1 September.
92. Marota I, Rollo F. 2002. Molecular paleontology. Cell Mol Life Sci 59: 97-111.
93. Marota I, Basile C, Ubaldi M, Rollo F. 2002. DNA decay rate in papyri and human remains from Egyptian archaeological sites. Am J Phys Anthropol 117: 310-318.
94. Mays S, Nerlich AG. 1997. A possible case of Langerhans' cell histiocytosis in a mediaeval child from an English cemetery. J Paleopathol 9: 73-81.
95. Mays S, Taylor GM, Legge AJ, Young DB, Turner-Walker G. 2001. Paleopathological and biomolecular study of tuberculosis in a medieval skeletal collection from England. Am J Phys Anthropol 114: 298-311.
96. Mays S, Fysh E, Taylor GM. 2002. Investigation of the link between visceral surface rib lesions and tuberculosis in a medieval skeletal series from England using ancient DNA. Am J Phys Anthropol 119: 27-36.
97. McDonald JP, Hall A, Gasparutto D, Cadet J, Ballantyne J, et al. 2006. Novel thermostable Y-family polymerases: applications for the PCR amplification of damaged or ancient DNAs. Nucleic Acids Res 34: 1102-1111.
98. McMichael AJ. 2004. Environmental and social influences on emerging infectious diseases: past, present and future. Phil Trans R Soc Lond B 359: 1049-1058.
99. Miller RL. 1997. Tetanus after cranial trauma in ancient Egypt. J Neurol Neurosurg Psychiatry 63: 758.
100. Miller RL, Armelagos GJ, Ikram S, De Jonge N, Krijger FW, et al. 1992. Palaeoepidemiology of Schistosoma infection in mummies. Br Med J 304: 555-556.
101. Miller RL, Ikram S, Armelagos GJ, Walker R, Harer WB, et al. 1994. Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual ParaSight™-F test. Trans R Soc Trop Med Hyg 88: 31-32.
102. Mokrousov I, Ly HM, Otten T, Lan NN, Vyshnevskyi B, et al. 2005. Origin and primary dispersal of the Mycobacterium tuberculosis Beijing genotype: clues from human phylogeography. Genome Res 15: 1357-1364.
103. Monot M, Honoré N, Garnier T, Araoz R, Coppée J-Y, et al. 2005. On the origin of leprosy. Science 308: 1040-1042.
104. Montiel R, Garcia C, Canadas MP, Isidro A, Guijo JM, et al. 2003. DNA sequences of Mycobacterium leprae recovered from ancient bones. FEMS Microbiol Lett 226: 413-414.
105. O'Rourke DH, Hayes MG, Carlyle SW. 2000. Ancient DNA studies in physical anthropology. Ann Rev Anthropol 29: 217-242.
106. Owen IL, Gomez Morales MA, Pezzotti P, Pozio E. 2005. Trichinella infection in a hunting population of Papua New Guinea suggests an ancient relationship between Trichinella and human beings. Trans R Soc Trop Med Hyg 99: 618-624.
107. Oxenham MF, Thuy NK, Cuong NL. 2005. Skeletal evidence for the emergence of infectious disease in Bronze and Iron Age northern Vietnam. Am J Phys Anthropol 126: 359-376.
108. Pääbo S. 1985. Molecular cloning of ancient Egyptian mummy DNA. Nature 314: 644-645.
109. Pääbo S. 1989. Ancient DNA: extraction, characterization, molecular cloning and enzymatic amplification. Proc Natl Acad SciUSA 86: 1939-1943.
110. Pääbo S, Poinar H, Serre D, Jaenicke-Despres V, Hebler J, et al. 2004. Genetic analyses from ancient DNA. Ann Rev Genet 38: 645-679.
111. Pinhasi R, Foley R, Donoghue HD. 2006. Reconsidering the antiquity of leprosy. Science 312: 846.
112. Poinar HN, Stankiewicz BA. 1999. Protein preservation and DNA retrieval from ancient tissues. Proc Natl Acad SciUSA 96: 8426-8431.
113. Poinar HN, Hofreiter M, Spaulding WG, Martin PS, Stankiewicz BA, et al. 1998. Molecular coproscopy: dung and diet of the extinct ground sloth Nothrotheriops shastensis. Science 281: 402-406.
114. Pusch CM, Rahalison L, Blin N, Nicholson GJ, Czarnetzki A. 2004. Yersinial F1 antigen and the cause of Black Death. Lancet Infect Dis 4: 484-485.
115. Rafi A, Spigelman M, Stanford J, Lemma E, Donoghue H, et al. 1994. DNA of Mycobacterium leprae detected by PCR in ancient bone. Int J Osteoarchaeol 4: 287-290.
116. Raoult D, Aboudharam G, Crubézy E, Larrouy G, Ludes B, et al. 2000. Molecular identification by 'suicide PCR' of Yersinia pestis as the agent of medieval Black Death. Proc Natl Acad Sci USA 97: 12 800-12 803.
117. Raoult D, Drancourt M, Fournier M, Ogata H. 2005. Discussion: Yersinia pestis genotyping. Emerg Infect Dis 11: 1318-1319.
118. Raoult D, Dutour O, Houhamdi L, Jankauskas R, Fournier PE, et al. 2006. Evidence for louse-transmitted diseases in soldiers of Napoleon's Grand Army in Vilnius. J Infect Dis 193: 112-120.
119. Rook GA, Rosa Brunet L. 2005. Microbes, immunoregulation, and the gut. Gut 54: 317-320.
120. Rothschild B, Martin L, Lev G, Bercovier H, Greenblatt C, et al. 2001. Mycobacterium-tuberculosiscomplex DNA from an extinct bison dated 17,000 years before the present. Clin Infect Dis 333: 305-311.
121. Ruffer MA. 1910. Note on the presence of Bilharzia haematobia in Egyptian mummies of the XXth dynasty (1250-1000 BC). Br Med J 1: 16.
122. Rutherford P. 1999. Immunocytochemistry and the diagnosis of schistosomiasis: ancient and modern. Parasitol Today 15: 390-391.
123. Rutherford P. 2005. Schistosomiasis in modern and ancient tissues. J Biol Res 80: 80-83.
124. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, et al. 1985. Enzymatic amplification of beta-globulin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230: 1350-1354.
125. Saiki RK, Geland DH, Stoffel S, Scharf SJ, Higuchi R, et al. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239: 487-491.
126. Sallares R, Gomzi S. 2001. Biomolecular archaeology of malaria. Ancient Biomol 3: 195-213.
127. Sallares R, Bouwman A, Anderung C. 2004. The spread of malaria to southern Europe in antiquity: new approaches to old problems. Med Hist 48: 311-328.
128. Salo WL, Aufderheide AC, Buikstra J, Holcomb TA. 1994. Identification of Mycobacterium tuberculosis DNA in a pre-Columbian Peruvian mummy. Proc Natl Acad Sci USA 91: 2091-2094.
129. Santos AL, Roberts CA. 2006. Anatomy of a serial killer: differential diagnosis of tuberculosis based on rib lesions of adult individuals from the Coimbra Identified Skeletal Collection, Portugal. Am J Phys Anthropol 130: 38-49.
130. Sawicki VA, Allison MJ, Dalton HP. 1976. Presence of Salmonella antigens in feces from a Peruvian mummy. Bull N Y Acad Med 52: 805-813.
131. Schmidt-Schultz TH, Schultz M. 2004. Bone protects proteins over thousands of years: extraction, analysis, and interpretation of extracellular matrix proteins in archaeological skeletal remains. Am J Phys Anthropol 123: 30-39.
132. Schultz M. 2001. Paleohistopathology of bones: a new approach to the study of ancient diseases. Yrbk Phys Anthropol 44: 104-147.
133. Sebbane F, Jarrett CO, Gardner D, Long D, Hinnebusch BJ. 2006. Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague. Proc Natl Acad SciUSA 103: 5526-5530.
134. Shin DH, Youn M, Chang BS. 2003. Histological analysis on the medieval mummy in Korea. Forensic Sci Int 137: 172-182.
135. Smith CI, Chamberlain AT, Riley MS, Stringer C, Collins MJ. 2003. The thermal history of human fossils and the likelihood of successful DNA amplification. J Hum Evol 45: 203-217.
136. Spigelman M, Donoghue HD. 2001. Brief communication: unusual pathological condition in the lower extremities of a skeleton from ancient Israel. Am J Phys Anthropol 114: 92-93.
137. Spigelman M, Donoghue HD. 2003. Paleobacteriology with special reference to pathogenic mycobacteria. In Emerging Pathogens: Archaeology, Ecology and Evolution of Infectious Disease, Greenblatt C, Spigelman M (eds). Oxford University Press: Oxford; 175-188.
138. Spigelman M, Greenblatt CL. 1998. A guide to digging for pathogens. In Digging for Pathogens: Ancient Emerging Diseases-their Evolutionary, Anthropological, and Archaeological Context, Greenblatt CL (ed.). Rehovot: Balaban Publishers: Rehovot; 345-361.
139. Spigelman M, Lemma E. 1993. The use of polymerase chain reaction to detect Mycobacterium tuberculosis in ancient skeletons. Int J Osteoarchaeol 3:137-143.
140. Spigelman M, Matheson C, Lev M, Greenblatt C, Donoghue HD. 2003. Confirmation of the presence of Mycobacterium tuberculosis-complex specific DNA in three archaeological specimens. Int J Osteoarchaeol 12: 393-401.
141. Spigelman M, Greenblatt C, Vernon K, Zylber MI, Sheridon S, et al. 2005. Preliminary findings on the paleomicrobiological study of 400 naturally mummified human remains from Upper Nubia. J Biol Res 80: 91-95.
142. Spigelman M, Pap I, Donoghue HD. 2006. A death from Langerhans cell histiocytosis and tuberculosis in 18th century Hungary-what palaeopathology can tell us today. Leukemia 20: 740-742.
143. Stenseth NC, Samia NI, Viljugrein H, Krausrud KL, Begon M, et al. 2006. Plague dynamics are driven by climate variation. Proc Natl Acad SciUSA 103: 13 110-13 115.
144. Stiller M, Green RE, Ronan M, Simons JF, Du L, et al. 2006. Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA. Proc Natl Acad Sci USA 103: 13578-13584. Correction: Proc Natl Acad Sci USA 103: 14977.
145. Sutlovic D, Gojanovic MD, Andelinovic S, Gugic D, Primorac D. 2005. Taq polymerase reverses inhibition of quantitative real-time polymerase chain reaction by humic acid. Croat Med J 46: 556-562.
146. Taubenberger JK, Morens DM. 2006. 1918 Influenza: the mother of all pandemics. Emerg Infect Dis 12: 15-22.
147. Taylor GM, Rutland P, Molleson T. 1997. A sensitive polymerase chain reaction method for the detection of Plasmodium species DNA in ancient human remains. Ancient Biomol 1: 193-203.
148. Taylor GM, Widdison S, Brown IN, Young D. 2000. A mediaeval case of lepromatous leprosy from 13-14th century Orkney, Scotland. J Archaeol Sci 27: 1133-1138.
149. Taylor GM, Young DB, Mays SA. 2005. Genotypic analysis of the earliest known prehistoric case of tuberculosis in Britain. J Clin Microbiol 43: 2236-2240.
150. Taylor GM, Watson CL, Bouwman AS, Lockwood DNJ, Mays SA. 2006. Variable number tandem repeat (VNTR) typing of two palaeopathological cases of lepromatous leprosy from mediaeval England. J Archaeol Sci 33: 1569-1579.
151. Taylor GM, Murphy E, Hopkins R, Rutland P, Chitov Y. 2007. First report of Mycobacterium bovis DNA in human remains from the Iron Age. Microbiology 153: 1243-1249.
152. Vergnaud G. 2005. Yersinia pestis genotyping. Emerg Infect Dis 11: 1317-1318.
153. Villeneuve M, Kawai M, Kanashima H, Watanabe M, Minnikin DE, et al. 2005. Temperature dependence of the Langmuir monolayer packing of mycolic acids from Mycobacterium tuberculosis. Biochim Biophys Acta Biomembranes 1715: 71-80.
154. Wang GC, Wang Y. 1997. Frequency of formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes. Appl Environ Microbiol 63: 4645-4650.
155. Weiss RA, McMichael AJ. 2004. Social and environmental risk factors in the emergence of infectious diseases. Nature Med 10(12 Suppl): S70-S76.
156. Wiechmann I, Grupe G. 2005. Detection of Yersinia pestis DNA in two early medieval skeletal finds from Aschheim (Upper Bavaria, 6th century A.D.). Am J Phys Anthropol 126: 48-55.
157. Willerslev E, Cooper A. 2005. Review paper. Ancient DNA. Proc Biol Sci 272: 3-16.
158. Willerslev E, Cooper A. 2006. Reply. Pathogenic microbial ancient DNA: a problem or an opportunity? Proc R Soc B 273: 643.
159. Zhou D, Han Y, Song Y, Huang P, Yang R. 2004. Comparative and evolutionary genomics of Yersinia pestis. Microbes Infect 6: 1226-1234.
160. Zink A, Nerlich AG. 2001. A case of Langerhans cell histiocytosis in an infant of a late Roman cemetery. J Palaeopathol 13: 67-73.
161. Zink A, Nerlich AG. 2003. Molecular analyses of the 'pharaos': feasibility of molecular studies in ancient Egyptian material. Am J Phys Anthropol 121: 109-111.
162. Zink AR, Nerlich AG. 2005. Long-term survival of ancient DNA in Egypt: Reply to Gilbert et al. Am J Phys Anthropol 128: 115-118.
163. Zink A, Reischl U, Wolf H, Nerlich A. 2000. Molecular evidence for bacteremia by gastrointestinal pathogenic bacteria in an infant mummy from ancient Egypt. Arch Pathol Lab Med 124: 1614-1618.
164. Zink A, Haas CJ, Herberth K, Nerlich AG. 2001. PCR amplification of Plasmodium DNA in ancient human remains. Ancient Biomol 3: 293.
165. Zink AR, Reischl U, Wolf H, Nerlich AG. 2002. Molecular analysis of ancient microbial infections. FEMS Microbiol Lett 213: 141-147.
166. Zink A, Grabner W, Reischl U, Wolf H, Nerlich AG. 2003. Molecular study on human tuberculosis in three geographically distinct and time delineated populations from ancient Egypt. Epidemiol Infect 130: 239-249.
167. Zink AR, Grabner W, Nerlich AG. 2005a. Molecular identification of human tuberculosis in recent and historic bone tissue samples: the role of molecular techniques for the study of historic tuberculosis. Am J Phys Anthropol 126: 32-47.
168. Zink AR, Köhler S, Motamedi N, Reischl U, Wolf H, et al. 2005b. Preservation and identification of ancient M. tuberculosis complex DNA in Egyptian mummies. J Biol Res 80: 84-87.
169. Zink AR, Spigelman M, Schraut B, Greenblatt GL, Nerlich A, et al. 2006. Leishmaniasis in ancient Egypt and Upper Nubia. Emerg Inf Dis 12: 1616-1617.