Adult-onset degeneration of adipose tissue in mice deficient for the Sox8 transcription factor

Journal of Lipid Research

Volumn 50, Issue 7, 2009, Pages 1269-1280

  Guth, Sabine I E ^a   Schmidt, Katy ^a   Hess, Andreas ^b   Wegner, Michael ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

High mobility group; Mesoderm; Sry; Transgenic mouse model

Indexed keywords

CELL PROTEIN; GLUCOSE; LEPTIN; NORADRENALIN; PROTEIN PREF 1; SOMATOMEDIN C; TRANSCRIPTION FACTOR SOX8; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; AGE DISTRIBUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST CULTURE; GLUCOSE METABOLISM; LIPODYSTROPHY; MALE; MESODERM; MOUSE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TISSUE DEGENERATION; TISSUE DISTRIBUTION; WEIGHT REDUCTION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; FIBROBLASTS; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; SOXE TRANSCRIPTION FACTORS;

EID: 67650544188     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800531-JLR200     Document Type: Article

References (50)

1. Bowles, J., G. Schepers, and P. Koopman. 2000. Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. Dev. Biol. 227: 239-255.
2. Wegner, M. 1999. From head to toes: the multiple facets of Sox proteins. Nucleic Acids Res. 27: 1409-1420.
3. Guth, S. I. E., and M. Wegner. 2008. Having it both ways: Sox protein function between conservation and innovation. Cell. Mol. Life Sci. 65: 3000-3018.
4. Cheung, M., and J. Briscoe. 2003. Neural crest development is regulated by the transcription factor Sox9. Development. 130: 5681-5693.
5. Kellerer, S., S. Schreiner, C. C. Stolt, M. R. Bösl, and M. Wegner. 2006. Functional equivalency of transcription factors Sox8 and Sox10 is tissue-specific. Development. 133: 2875-2886.
6. Chaboissier, M-C., A. Kobayashi, V. I. P. Vidal, S. Lützkendorf, H. J. G. van de Kant, M. Wegner, D. G. de Rooij, R. R. Behringer, and A. Schedl. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development. 131: 1891-1901.
7. Stolt, C. C., P. Lommes, R. P. Friedrich, and M. Wegner. 2004. Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development. 131: 2349-2358.
8. O'Donnell, M., C. S. Hong, X. Huang, R. J. Delnicki, and J. P. Saint-Jeannet. 2006. Functional analysis of Sox8 during neural crest development in Xenopus. Development. 133: 3817-3826.
9. Akiyama, H., M-C. Chaboissier, R. Behringer, D. H. Rowitch, A. Schedl, J. A. Epstein, and B. de Crombrugghe. 2004. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc. Natl. Acad. Sci. USA. 101: 6502-6507.
10. Akiyama, H., M-C. Chaboissier, J. F. Martin, A. Schedl, and B. de Crombrugghe. 2002. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16: 2813-2828.
11. Bi, W., J.M. Deng, Z. Zhang, R. R. Behringer, and B. de Crombrugghe. 1999. Sox9 is required for cartilage formation. Nat. Genet. 22: 85-89.
12. Stolt, C. C., P. Lommes, E. Sock, M-C. Chaboissier, A. Schedl, and M. Wegner. 2003. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 17: 1677-1689.
13. Mori-Akiyama, Y., M. van den Born, J. H. van Es, S. R. Hamilton, H. P. Adams, J. Zhang, H. Clevers, and B. de Crombrugghe. 2007. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology. 133: 539-546.
14. Britsch, S., D. E. Goerich, D. Riethmacher, R. I. Peirano, M. Rossner, K. A. Nave, C. Birchmeier, and M. Wegner. 2001. The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev. 15: 66-78.
15. Herbarth, B., V. Pingault, N. Bondurand, K. Kuhlbrodt, I. Hermans-Borgmeyer, A. Puliti, N. Lemort, M. Goossens, and M. Wegner. 1998. Mutation of the Sry-related Sox10 gene in Dominant megacolon: a mouse model for human Hirschsprung disease. Proc. Natl. Acad. Sci. USA. 95: 5161-5165.
16. Southard-Smith, E. M., L. Kos, and W. J. Pavan. 1998. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat. Genet. 18: 60-64.
17. Stolt, C. C., S. Rehberg, M. Ader, P. Lommes, D. Riethmacher, M. Schachner, U. Bartsch, and M. Wegner. 2002. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev. 16: 165-170.
18. Wagner, T., J. Wirth, J. Meyer, B. Zabel, M. Held, J. Zimmer, J. Pasantes, F. D. Bricarelli, J. Keutel, E.Hustert, et al. 1994. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene Sox9. Cell. 79: 1111-1120.
19. Foster, J. W., M. A. Dominguez-Steglich, S. Guioli, C. Kwok, P. A. Weller, M. Stevanovic, J. Weissenbach, S. Mansour, I. D. Young, P. N. Goodfellow, et al. 1994. Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature. 372: 525-530.
20. Inoue, K., M. Khajavi, T. Ohyama, S-i. Hirabayashi, J. Wilson, J. D. Reggin, P. Mancias, I. J. Butler, M. F. Wilkinson, M. Wegner, et al. 2004. Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat. Genet. 36: 361-369.
21. Pingault, V., N. Bondurand, K. Kuhlbrodt, D. E. Goerich, M-O. Prehu, A. Puliti, B. Herbarth, I. Hermans-Borgmeyer, E. Legius, G. Matthijs, et al. 1998. Sox10 mutations in patients with Waardenburg-Hirschsprung disease. Nat. Genet. 18: 171-173.
22. Sock, E., K. Schmidt, I. Hermanns-Borgmeyer, M. R. Bösl, an M. Wegner. 2001. Idiopathic weight reduction in mice deficient in the high-mobility-group transcription factor Sox8. Mol. Cell. Biol. 21: 6951-6959.
23. O'Bryan, M. K., S. Takada, C. L. Kennedy, G. Scott, S. Harada, M. K. Ray, Q. Dai, D. Wilhelm, D. M. de Kretser, E. M. Eddy, et al. 2008. Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev. Biol. 316: 359-370.
24. Pfeifer, D., F. Poulat, E. Holinski-Feder, F. Kooy, and G. Scherer. 2000. The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome. Genomics. 63: 108-116.
25. Schmidt, K., T. Schinke, M. Haberland, M. Priemel, A. F. Schilling, C. Mueldner, J. M. Rueger, E. Sock, M. Wegner, and M. Amling. 2005. The high-mobility-group transcription factor Sox8 is a negative regulator of osteoblast differentiation. J. Cell Biol. 168: 899-910.
26. Maka, M., C. C. Stolt, and M. Wegner. 2005. Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect. Dev. Biol. 277: 155-169.
27. Lee, N. K., H. Sowa, E. Hinoi, M. Ferron, J. D. Ahn, C. Confavreux, R. Dacquin, P. J. Mee, M. D. McKee, D. Y. Jung, et al. 2007. Endocrine regulation of energy metabolism by the skeleton. Cell. 130: 456-469.
28. Rosen, E. D., C. J. Walkey, P. Puigserver, and B. M. Spiegelman. 2000. Transcriptional regulation of adipogenesis. Genes Dev. 14: 1293-1307.
29. Cong, L., K. Chen, J. Li, P. Gao, Q. Li, S. Mi, X. Wu, and A. Z. Zhao. 2007. Regulation of adiponectin and leptin secretion and expression by insulin through a PI3K-PDE3B dependent mechanism in rat primary adipocytes. Biochem. J. 403: 519-525.
30. Trayhurn, P., J. S. Duncan, D. V. Rayner, and L. J. Hardie. 1996. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem. Biophys. Res. Commun. 228: 605-610.
31. Baskin, D., J. Breininger, and M. Schwartz. 1999. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes. 48: 828-833.
32. Cheung, C., D. Clifton, and R. Steiner. 1997. Proopimelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology. 138: 4489-4492.
33. Schwartz, M. W., S. C. Woods, D. Porte, R. Seeley, and D. G. Baskin. 2000. Central nervous system control of food intake. Nature. 404: 661-671.
34. Villena, J. A., K. H. Kim, and H. S. Sul. 2002. Pref-1 and ADSF/ resistin: two secreted factors inhibiting adipose tissue development. Horm. Metab. Res. 34: 664-670.
35. Valet, P., G. Tavernier, I. Castan-Laurell, J. S. Saulnier-Blache, and D. Langin. 2002. Understanding tissue development from transgenic animal models. J. Lipid Res. 43: 835-860.
36. Gesta, S., Y-H. Tseng, and C. R. Kahn. 2007. Developmental origin of fat: tracking obesity to its source. Cell. 131: 242-256.
37. Akiyama, H., J. E. Kim, K. Nakashima, G. Balmes, N. Iwai, J. M. Deng, Z. Zhang, J. F. Martin, R. R. Behringer, T. Nakamura, et al. 2005. Osteo-chondroprogenitor cells are derived from Sox9 expressin precursors. Proc. Natl. Acad. Sci. USA. 102: 14665-14670.
38. Schmid, R. S., S. Shelton, A. Stanco, Y. Yokota, J. A. Kreidberg, and E. S. Anton. 2004. Alpha3 beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development. Development. 131: 6023-6031.
39. Schmidt, K., G. Glaser, A. Wernig, M. Wegner, and O. Rosorius. 2003. Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis. J. Biol. Chem. 278: 29769-29775.
40. Billon, N., P. Iannarelli, M. C. Monteiro, C. Glavieux-Pardanaud, W. D. Richardson, N. Kessaris, C. Dani, and E. Dupin. 2007. The generation of adipocytes by the neural crest. Development. 134: 2283-2292.
41. Tanaka, T., N. Yoshida, T. Kishimoto, and S. Akira. 1997. Defective adipocyte differentiation in mice lacking the C/EBPb and C/EBPy gene. EMBO J. 16: 7432-7443.
42. Wang, N-D., M. J. Finegold, A. Bradley, C. N. Ou, S. V. Abdelsayed, M. D. Wilde, L. R. Taylor, D. R. Wilson, and G. J. Darlington. 1995. Impaired energy homeostasis in C/EBPa knockout mice. Science. 269: 1108-1112.
43. Kubota, N., Y. Terauchi, H. Miki, H. Tamemoto, T. Yamauchi, K. Komeda, S. Satoh, R. Nakano, C. Ishii, T. Sugiyama, et al. 1999. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell. 4: 597-609.
44. Rosen, E. D., P. Sarraf, A. E. Troy, G. Bradwin, K.Moore, D. S.Milstone, B. M. Spiegelman, and R. M. Mortensen. 1999. PPARγ is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell. 4: 611-617.
45. Anand, A., and K. Chada. 2000. In vivo modulation of Hmgic reduces obesity. Nat. Genet. 24: 377-380.
46. Kamachi, Y., M. Uchikawa, and H. Kondoh. 2000. Pairing SOX off with partners in the regulation of embryonic development. Trends Genet. 16: 182-187.
47. Wegner, M. 2005. Secrets to a healthy Sox life: Lessons for melanocytes. Pigment Cell Res. 18: 74-85.
48. Spalding, K. L., E. Arner, P.O.Westermark, S. Bernard, B. A. Buchholz, O. Bergmann, L. Blomqvist, J. Hoffstedt, E. Naslund, T. Britton, et al. 2008. Dynamics of fat cell turnover in humans. Nature. 453: 783-787.
49. Rodeheffer, M. S., K. Birsoy, and J. M. Friedman. 2008. Identification of white adipocyte progenitor cells in vivo. Cell. 135: 240-249.
50. Tang,W., D. Zeve, J. M. Suh, D. Bosnakovski, M. Kyba, R. E. Hammer, M. D. Tallquist, and J. M. Graff. 2008. White fat progenitor cells reside in the adipose vasculature. Science. 322: 583-586.