Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities

Molecular Immunology

Volumn 46, Issue 13, 2009, Pages 2465-2473

  van Dijk, Albert ^a   Molhoek, E Margo ^b   Veldhuizen, Edwin J A ^a   Bokhoven, Johanna L M Tjeerdsma van ^a   Wagendorp, Eveline ^a   Bikker, Floris ^b   Haagsman, Henk P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

Author keywords

Antibacterial activity; Cathelicidin; Chicken; Cytotoxicity; Host defense peptide; Immunomodulation; Innate immunity

Indexed keywords

CATHELICIDIN; CATHELICIDIN 2; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CARBOXY TERMINAL SEQUENCE; CHICKEN; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; HEMOLYSIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL SURVIVAL; CELLS, CULTURED; CHEMOKINE CCL2; CHICKENS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FEMALE; HEMOLYSIS; HUMANS; IMMUNOLOGIC FACTORS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY;

BACTERIA (MICROORGANISMS);

EID: 67650508049     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.05.019     Document Type: Article

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