Essential role of the Ly49A stalk region for immunological synapse formation and signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11264-11269

  Ito, Daisuke ^a   Iizuka, Yoshie Matsubayashi ^a   Katepalli, Madhu P ^a   Iizuka, Koho ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

MHC; NK cells; NK receptor

Indexed keywords

NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR LY49A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL; CIS ISOMER; CONTROLLED STUDY; IMMUNOBIOLOGY; LIGAND BINDING; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; SYNAPSE; TARGET CELL; TRANS ISOMER;

AMINO ACID SEQUENCE; ANIMALS; GENE DELETION; GENES, REPORTER; IMMUNOLOGICAL SYNAPSES; LIGANDS; MICE; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY A; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SOLUBILITY;

MURINAE;

EID: 67650497723     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0900664106     Document Type: Article

References (28)

1. Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL (2002) Viral evasion of natural killer cells. Nat Immunol 3:1006-1012.
2. Lodoen MB, Lanier LL(2005) ViralmodulationofNKcellimmunity. Nat Rev Microbiol 3:59-69.
3. Gasser S, Raulet D (2006) The DNA damage response, immunity and cancer. Semin Cancer Biol 16:344-347.
4. Long EO (1999) Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17:875-904.
5. Lanier LL (2005) NK cell recognition. Annu Rev Immunol 23:225-274.
6. Vivier E, Nunes JA, Vely F (2004) Natural killer cell signaling pathways. Science 306:1517-1519.
7. Karlhofer FM, Ribaudo RK, Yokoyama WM (1992) MHC class I alloantigen specificity of Ly-49 + IL-2-activated natural killer cells. Nature 358:66-70.
8. Doucey MA, et al. (2004) Cis association of Ly49A with MHC class I restricts natural killer cell inhibition. Nat Immunol 5:328-336.
9. Scarpellino L, et al. (2007) Interactions of Ly49 family receptors with MHC class I ligands in trans and cis. J Immunol 178:1277-1284.
10. d: Identification of a site distinct form the TCR site. Immunity 11:591-601.
11. Wang J, et al. (2002) Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin. J Biol Chem 277:1433-1442.
12. Tormo J, Natarajan K, Margulies DH, Mariuzza RA (1999) Crystal structure of a lectinlike natural killer cell receptor bound to its MHC class I ligand. Nature 402:623-631.
13. Matsumoto N, Mitsuki M, Tajima K, Yokoyama WM, Yamamoto K (2001) The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand. J Exp Med 193:147-158.
14. Held W, Mariuzza RA (2008) Cis interactions of immunoreceptors with MHC and non-MHC ligands. Nat Rev Immunol 8:269-278.
15. Leibson PJ, Pease LR (2004) Having it both ways: MHC recognition in cis and trans. Nat Immunol 5:237-238.
16. Davis DM (2002) Assembly of the immunological synapse for T cells and NK cells. Trends Immunol 23:356-363.
17. Davis DM, Dustin ML (2004) What is the importance of the immunological synapse? Trends Immunol 25:323-327.
18. Dustin ML (2004) Stop and go traffic to tune T cell responses. Immunity 21:305-314.
19. Banerjee PP, et al. (2007) Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. J Exp Med 204:2305-2320.
20. Orange JS (2008) Formation and function of the lytic NK-cell immunological synapse. Nat Rev Immunol 8:713-725.
21. Cochran JR, Aivazian D, Cameron TO, Stern LJ (2001) Receptor clustering and transmembrane signaling in T cells. Trends Biochem Sci 26:304-310.
22. Janeway CA, Jr (1995) Ligands for the T-cell receptor: Hard times for avidity models. Immunol Today 16:223-225.
23. Dam J, et al. (2006) Variable dimerization of the Ly49A natural killer cell receptor results in differential engagement of its MHC class I ligand. J Mol Biol 362:102-113.
24. Davis DM, et al. (1999) The human natural killer cell immune synapse. Proc Natl Acad Sci USA 96:15062-15067.
25. Dam J, et al. (2003) Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K (b). Nat Immunol 4:1213-1222.
26. Aivazian D, Stern LJ (2000) Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition. Nat Struct Biol 7:1023-1026.
27. Kim S, et al. (2005) Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436:709-713.
28. Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM (2003) Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol 4:801-807.