A novel phospholipid-based drug formulation, VP025, modulates age- and LPS-induced microglial activity in the rat

NeuroImmunoModulation

Volumn 16, Issue 6, 2009, Pages 400-410

  Martin, Darren S D ^a,b   Walsh, Michelle ^a,b   Miller, Anne Marie ^a   Skerrett, Helen E ^b   Byrne, Patricia ^b   Mandel, Arkady ^d   Bolton, Anthony E ^c   Lynch, Marina A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c Vasogen Ireland Ltd   (Ireland)

^d Vasogen Inc   (Canada)

Author keywords

Ageing; Cytokines; Hippocampus; Inflammation; Interleukin 1 ; Long term potentiation; Macrophage; Microglia; Phospholipid

Indexed keywords

CD200 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; NANOPARTICLE; PHOSPHATIDYLGLYCEROL; PHOSPHOLIPID DERIVATIVE; UNCLASSIFIED DRUG; VP 025;

ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN NERVE CELL; CASE REPORT; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG FORMULATION; DRUG MECHANISM; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMAN; HUMAN CELL; INFLAMMATION; LONG TERM POTENTIATION; MALE; MICROGLIA; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SUPERNATANT; TARGET CELL;

ADULT; AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS; ENCEPHALITIS; GLIOSIS; HIPPOCAMPUS; HUMANS; IMMUNOMODULATION; INTERFERON-GAMMA; INTERLEUKIN-1BETA; LONG-TERM POTENTIATION; MACROPHAGES; MALE; MEMORY DISORDERS; MICROGLIA; NANOPARTICLES; PERFORANT PATHWAY; PHAGOCYTOSIS; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPIDS; RATS; RATS, WISTAR; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67650489062     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000228915     Document Type: Article

References (42)

1. Suzuki Y, Claflin J, Wang X, Lengi A, Kikuchi T: Microglia and macrophages as innate producers of interferon-gamma in the brain following infection with Toxoplasma gondii . Int J Parasitol 2005;35:83-90. (Pubitemid 41556675)
2. Babcock AA, Kuziel WA, Rivest S, Owens T: Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci 2003;23:7922-7930. (Pubitemid 37052361)
3. Wang H, Sun J, Goldstein H: HIV-1 infection increases the in vivo capacity of peripheral monocytes to cross the blood brain barrier into the brain and the in vivo sensitivity of the blood brain barrier to disruption by LPS. J Virol 2008;82:7591-7600.
4. Fan H, Zingarelli B, Harris V, Tempel GE, Halushka PV, Cook JA: Lysophosphatidic acid inhibits bacterial endotoxin-induced pro-inflammatory response: potential antiinflammatory signaling pathways. Mol Med 2008;14:422-428.
5. Lee SJ, Lim KT: Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-α and COX-2 via activation of PKCα and ERK 1/2 in LPS-stimulated RAW 264.7 cells. Mol Cell Biochem 2008;317:151-159.
6. Greene CM, McElvaney NG, O'Neill SJ, Taggart CC: Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells. Infect Immun 2004;72:3684-3687.
7. Lynch MA: Long-term potentiation and memory. Physiol Rev 2004;84:87-136.
8. Murray CA, Lynch MA: Evidence that increased hippocampal expression of the cytokine interleukin-1β is a common trigger for age- and stress-induced impairments in long-term potentiation. J Neurosci 1998;18:2974-2981.
9. Lynch AM, Lynch MA: The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation. Eur J Neurosci 2002;15:1779-1788.
10. Martin DSD, Lonergan PE, Boland B, Fogarty MP, Brady M, Horrobin DF, Campbell VA, Lynch MA: Apoptotic changes in the aged brain are triggered by interleukin-1β-induced activation of p38 and reversed by treatment with eicosapentaenoic acid. J Biol Chem 2002;277:34239-34246. (Pubitemid 35056245)
11. Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, Johnson RW: Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system. FASEB J 2005;19:1329-1331. (Pubitemid 41113739)
12. Lonergan PE, Martin DS, Horrobin DF, Lynch MA: Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus. J Neurochem 2004;91:20-29.
13. Lynch AM, Moore M, Craig S, Lonergan PE, Martin DS, Lynch MA: Analysis of interleukin-1β-induced cell signaling activation in rat hippocampus following exposure to gamma irradiation. Protective effect of eicosapentaenoic acid. J Biol Chem 2003;278:51075-51084. (Pubitemid 38020342)
14. Davies CA, Loddick SA, Toulmond S, Stroemer RP, Hunt J, Rothwell NJ: The progression and topographic distribution of interleukin-1β expression after permanent middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1999;19:87-98. (Pubitemid 29283584)
15. Li Y, Liu L, Barger SW, Griffin WS: Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J Neurosci 2003;23:1605-1611. (Pubitemid 36314715)
16. Benveniste E, Nyuyen VT, O'Keefe GM: Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem Int 2001;39:381-391. (Pubitemid 32907402)
17. O'Keefe GM, Nguyen VT, Benveniste EN: Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases. J Neurovirol 2002;8:496-512.
18. Tan J, Town T, Crawford F, Mori T, Delledomme A, Crescentini R, Obregon D, Flavell RA, Mullam MJ: Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nature Neurosci 2002;5:1288-1293. (Pubitemid 35417763)
19. Nolan Y, Martin D, Campbell VA, Lynch MA: Evidence of a protective effect of phosphatidylserine-containing liposomes on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus. J Neuroimmunol 2004;151:12-23. (Pubitemid 38624395)
20. Fan LW, Pang Y, Lin S, Tien LT, Ma T, Rhodes PG, Cai Z: Minocycline reduces lipopolysaccharide-induced neurological dysfunction and brain injury in the neonatal rat. J Neurosci Res 2005;82:71-82. (Pubitemid 41604799)
21. Griffin R, Nally R, Nolan Y, McCartney Y, Lindon J, Lynch MA: Age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem 2006;99:1263-1272. (Pubitemid 44655290)
22. Hatherley D, Barclay AN: The CD200 and CD200 receptor cell surface proteins interact through their N-terminal immunoglobulinlike domains. Eur J Immunol 2004;34:1688-1694. (Pubitemid 39256051)
23. Barclay AN, Wright GJ, Brooke G, Brown MH: CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol 2002;23:285-290. (Pubitemid 34628770)
24. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD: Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol. 2002;161:1669-1677. (Pubitemid 35265526)
25. Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA: CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J Neurosci 2007;27:8309-8313. (Pubitemid 47219605)
26. Downer EJ, Cowley TR, Lyons A, Mills KH, Berezin V, Bock E, Lynch MA: A novel antiinflammatory role of NCAM-derived mimetic peptide, FGL. Neurobiol Aging DOI: 10.1016/200803017.
27. Frank MG, Barrientos RM, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF: mRNA upregulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. Neurobiol Aging 2006;27:717-722.
28. Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY, Henson PM: Macrophages that have ingested apoptotic cells in vitro inhibit pro-inflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β. J Clin Invest 1998;101:890-898.
29. Huynh ML, Fadok VA, Henson PM: Phosphatidylserine-dependant ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation. J Clin Invest 2002;109:41-50.
30. Hashimoto M, Asai Y, Ogawa T: Treponemal phospholipids inhibit innate immune responses induced by pathogen-associated molecular patterns. J Biol Chem 2003;278:44205-44213. (Pubitemid 37377164)
31. Crotty S, Fitzgerald P, Tuohy E, Harris DM, Fisher A, Mandel A, Bolton AE, Sullivan AM, Nolan Y: Neuroprotective effects of novel phosphatidylglycerol- based phospholipids in the 6-hydroxydopamine model of Parkinson's disease. Eur J Neurosci 2008;27:294-300.
32. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
33. Minogue AM, Schmid AW, Fogarty MP, Moore AC, Campbell VA, Herron CE, Lynch MA: Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-β on long term potentiation and cell death in hippocampus: a role for interleukin-1beta? J Biol Chem 2003;278:27971-27980.
34. Fadok VA, Bratton DL, Henson PM: Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Investig 2001;108:957-962.
35. 3 reverses agerelated inflammatory changes in the rat hippocampus. Biochem Soc Trans 2005;33:573-577.
36. Lynch AM, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O'Connell F, Lynch MA: Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus. Neurobiol Aging 2006;28:845-855. (Pubitemid 46589740)
37. Stolzing A, Grune T: Impairment of protein homeostasis and decline of proteasome activity in microglial cells from adult Wistar rats. J Neurosci Res 2003;71:264-271. (Pubitemid 36055471)
38. Kullberg S, Aldskogius H, Ulfhake B: Microglial activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord. Brain Res 2001;899:169-186. (Pubitemid 32324158)
39. Qin H, Wilson CA, Lee SJ, Zhao X, Benveniste EN: LPS induces CD40 gene expression through the activation of NF-κB and STAT-1α in macrophages and microglia. Blood 2005;106:3114-3122. (Pubitemid 41565908)
40. Huang Y, Henry CJ, Dantzer R, Johnson RW, Godbout JP: Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide. Neurobiol Aging. 2007;29:1744-1753.
41. Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA: Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus. J Neurochem 2005;93:221-231. (Pubitemid 40463531)
42. Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H: Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1β, and expression of caspase-11 in mice. J Biol Chem 2004;279:51647-51653. (Pubitemid 40017915)