Physicochemical properties and membrane interactions of anti-apoptotic derivatives 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine depending on the hydroxyalkylamino side chain length and conformation: An NMR and ESR study

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3509-3518

  Follot, Sébastien ^a   Debouzy, Jean Claude ^a   Crouzier, David ^a   Enguehard Gueiffier, Cécile ^b   Gueiffier, Alain ^b   Nachon, Florian ^a   Lefebvre, Bertrand ^a   Fauvelle, Florence ^a  

^a CENTRE DE RECHERCHES   (France)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

Apoptosis; Imidazo 1,2 a pyridine; Multilamellar vesicles; Nuclear Magnetic Resonance; Unilamellar vesicles

Indexed keywords

2 (4 FLUOROPHENYL) 3 (PYRIDIN 4 YL)IMIDAZO[1,2 A]PYRIDINE; 2 [2 (4 FLUOROPHENYL) 3 PYRIDIN 4 YLIMIDAZO[1,2 A]PYRIDIN 6 YLAMINO]ETHANOL; 4 [2 (4 FLUOROPHENYL) 3 PYRIDIN 4 YLIMIDAZO[1,2 A]PYRIDIN 6 YLAMINO]BUTAN 1 OL; 6 [2 (4 FLUOROPHENYL) 3 PYRIDIN 4 YLIMIDAZO[1,2 A]PYRIDIN 6 YLAMINO]HEXAN 1 OL; ALKYL GROUP; AMINE; BENZENE DERIVATIVE; FLUORINE DERIVATIVE; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; PHOSPHOLIPID; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG CONFORMATION; DRUG DESIGN; DRUG SOLUBILITY; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; HIGH RESOLUTION MAGIC ANGLE SPINNING; HUMAN; HUMAN CELL; MEMBRANE MODEL; MEMBRANE VESICLE; MOLECULAR INTERACTION; PARTITION COEFFICIENT; PHOSPHOLIPID MEMBRANE; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; SMALL UNILAMELLAR VESICLE; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CELL LINE, TUMOR; CELL MEMBRANE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; IMIDAZOLES; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PYRIDINES; SOLUBILITY; WATER;

EID: 67650462854     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.12.026     Document Type: Article

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