The involvement of substance P in the induction of aggressive behavior

Peptides

Volumn 30, Issue 8, 2009, Pages 1586-1591

  Katsouni, Eleni ^a   Sakkas, Pavlos ^b   Zarros, Apostolos ^a   Skandali, Nikolina ^a   Liapi, Charis ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Aggression; Aggressive attack; Defensive rage; Medial amygdaloid nucleus; Medial and lateral hypothalamus; NK1 receptor; Periaqueductal grey; Substance P

Indexed keywords

SUBSTANCE P; TACHYKININ RECEPTOR;

AGGRESSIVENESS; AMINO ACID SEQUENCE; BIOCHEMISTRY; DEFENSIVE BEHAVIOR; HUMAN; NEUROANATOMY; NEUROCHEMISTRY; NONHUMAN; PREDATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAGE; REVIEW; SOCIAL BEHAVIOR;

AGGRESSION; ANIMALS; ANXIETY DISORDERS; HUMANS; MOOD DISORDERS; RAGE; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 67650455881     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.05.001     Document Type: Review

References (99)

1. Adams D.B. Defence and territorial behaviour dissociated by hypothalamic lesions in the rat. Nature 232 (1971) 573-574
2. Albert D.J., Nanji N., Brayley K.N., and Madryga F.J. Hyperreactivity as well as mouse killing is induced by electrical stimulation of the lateral hypothalamus in the rat. Behav Neural Biol 27 (1979) 59-71
3. Alleva E., Aloe L., Bigi S., and De Acetis L. Capsaicin affects aggressive behavior, but not hot plate responding, of adult male mice. Physiol Behav 49 (1991) 715-719
4. Bannon M.J., Deutch A.Y., Tam S.Y., Zamir N., Eskay R.L., Lee J.M., et al. Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin. Brain Res 381 (1986) 393-396
5. Bannon M.J., and Whitty C.J. Neurokinin receptor gene expression in substantia nigra: localization, regulation, and potential physiological significance. Can J Physiol Pharmacol 73 (1995) 866-870
6. Barbaresi P. Immunocytochemical localization of substance P receptor in rat periaqueductal gray matter: a light and electron microscopic study. J Comp Neurol 398 (1998) 473-490
7. Barbeau A., Rondeau D.B., and Jolicoeur F.B. Behavioral effects of substance P in rats. Int J Neurol 14 (1980) 239-252
8. Beyer C., Caba M., Banas C., and Komisaruk B.R. Vasoactive intestinal polypeptide (VIP) potentiates the behavioral effect of substance P intrathecal administration. Pharmacol Biochem Behav 39 (1991) 695-698
9. Bhatt S., Gregg T.R., and Siegel A. NK1 receptors in the medial hypothalamus potentiate defensive rage behavior elicited from the midbrain periaqueductal gray of the cat. Brain Res 966 (2003) 54-64
10. Bigi S., De Acetis L., De Simone R., Aloe L., and Alleva E. Neonatal capsaicin exposure affects isolation-induced aggressive behavior and hypothalamic substance P levels of adult male mice (Mus musculus). Behav Neurosci 107 (1993) 363-369
11. Bolam J.P., and Smith Y. The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat. Brain Res 529 (1990) 57-78
12. Bourne A., Barnes K., Taylor B.A., Turner A.J., and Kenny A.J. Membrane peptidases in the pig choroid plexus and on other cell surfaces in contact with the cerebrospinal fluid. Biochem J 259 (1989) 69-80
13. Brodin E., Rosén A., Schött E., and Brodin K. Effects of sequential removal of rats from a group cage, and of individual housing of rats, on substance P, cholecystokinin and somatostatin levels in the periaqueductal grey and limbic regions. Neuropeptides 26 (1994) 253-260
14. Caberlotto L., Hurd Y.L., Murdock P., Wahlin J.P., Melotto S., Corsi M., et al. Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain. Eur J Neurosci 17 (2003) 1736-1746
15. Cheu J.W., and Siegel A. GABA receptor mediated suppression of defensive rage behavior elicited from the medial hypothalamus of the cat: role of the lateral hypothalamus. Brain Res 783 (1998) 293-304
16. Chi C.C., and Flynn J.P. Neural pathways associated with hypothalamically elicited attach behavior in cats. Science 171 (1971) 703-706
17. Chi C.C., and Flynn J.P. Neuroanatomic projections related to biting attack elicited from hypothalamus in cats. Brain Res 35 (1971) 49-66
18. Christ H. Effects of MET-ENK, substance P and SRIF on the behavior of Hemichromis bimaculatus. Peptides 6 (1985) 139-148
19. De Araújo J.E., Huston J.P., and Brandão M.L. Opposite effects of substance P fragments C (anxiogenic) and N (anxiolytic) injected into dorsal periaqueductal gray. Eur J Pharmacol 432 (2001) 43-51
20. De Araújo J.E., Huston J.P., and Brandão M.L. Place aversion induced by microinjections of C-fragment of substance P into the dorsal periaqueductal gray of rats is mediated by tachykinin NK1 receptors. Peptides 22 (2001) 1447-1452
21. De Felipe C., Herrero J.F., O'Brien J.A., Palmer J.A., Doyle C.A., Smith A.J., et al. Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. Nature 392 (1998) 394-397
22. Elliott P.J., and Iversen S.D. Behavioural effects of tachykinins and related peptides. Brain Res 381 (1986) 68-76
23. Elliott P.J., Nemeroff C.B., and Kilts C.D. Evidence for a tonic facilitatory influence of substance P on dopamine release in the nucleus accumbens. Brain Res 385 (1986) 379-382
24. File S.E. NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats. Psychopharmacology (Berl) 152 (2000) 105-109
25. Gadd C.A., Murtra P., De Felipe C., and Hunt S.P. Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse. J Neurosci 23 (2003) 8271-8280
26. Gallagher A.W., Chahl L.A., and Lynch A.M. Distribution of substance P-like immunoreactivity in guinea pig central nervous system. Brain Res Bull 29 (1992) 199-207
27. Garret C., Carruette A., Fardin V., Moussaoui S., Peyronel J.F., Blanchard J.C., et al. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci USA 88 (1991) 10208-10212
28. Geeraedts L.M., Nieuwenhuys R., and Veening J.G. Medial forebrain bundle of the rat: III. Cytoarchitecture of the rostral (telencephalic) part of the medial forebrain bundle bed nucleus. J Comp Neurol 294 (1990) 507-536
29. Geeraedts L.M., Nieuwenhuys R., and Veening J.G. Medial forebrain bundle of the rat: IV. Cytoarchitecture of the caudal (lateral hypothalamic) part of the medial forebrain bundle bed nucleus. J Comp Neurol 294 (1990) 537-568
30. Gerfen C.R., and Young III W.S. Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study. Brain Res 460 (1988) 161-167
31. Gregg T.R. Cortical and limbic neural circuits mediating aggressive behavior. In: Mattson M.P. (Ed). Neurobiology of aggression: understanding and preventing violence (2003), Humana Press, Totowa, NJ, USA 1-20
32. Gregg T.R., and Siegel A. Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression. Prog Neuropsychopharmacol Biol Psychiatry 25 (2001) 91-140
33. Gregg T.R., and Siegel A. Differential effects of NK1 receptors in the midbrain periaqueductal gray upon defensive rage and predatory attack in the cat. Brain Res 994 (2003) 55-66
34. Hall M.E., and Stewart J.M. Modulation of isolation-induced fighting by N- and C-terminal analogs of substance P: evidence for multiple recognition sites. Peptides 5 (1984) 85-89
35. Hall M.E., and Stewart J.M. Substance P and behavior: opposite effects of N-terminal and C-terminal fragments. Peptides 4 (1983) 763-768
36. Hallberg M., Johansson P., Kindlundh A.M., and Nyberg F. Anabolic-androgenic steroids affect the content of substance P and substance P(1-7) in the rat brain. Peptides 21 (2000) 845-852
37. Han Y., Shaikh M.B., and Siegel A. Medial amygdaloid suppression of predatory attack behavior in the cat: I. Role of a substance P pathway from the medial amygdala to the medial hypothalamus. Brain Res 716 (1996) 59-71
38. Helke C.J., Krause J.E., Mantyh P.W., Couture R., and Bannon M.J. Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms. FASEB J 4 (1990) 1606-1615
39. Herpfer I., and Lieb K. Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential. CNS Drugs 19 (2005) 275-293
40. Hershey A.D., and Krause J.E. Molecular characterization of a functional cDNA encoding the rat substance P receptor. Science 247 (1990) 958-962
41. Igwe O.J., Sun X., and Larson A.A. Role of substance P amino terminal metabolites in substance P-induced desensitization in mice. Neuroscience 36 (1990) 535-542
42. Jacobs C., Van Den Broeck W., and Simoens P. Increased volume and neuronal number of the basolateral nuclear group of the amygdaloid body in aggressive dogs. Behav Brain Res 170 (2006) 119-125
43. Jacobs C., Van Den Broeck W., and Simoens P. Neurokinin-1 receptor in the basolateral nuclear group of the canine amygdala-comparative study in normal and aggressive dogs. Brain Res 1098 (2006) 106-112
44. Karler R., Calder L.D., Thai L.H., and Bedingfield J.B. The dopaminergic, glutamatergic, GABAergic bases for the action of amphetamine and cocaine. Brain Res 671 (1995) 100-104
45. Kelley A.E., Cador M., and Stinus L. Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat. Psychopharmacology (Berl) 85 (1985) 37-46
46. Koolhaas J.M. Hypothalamically induced intraspecific aggressive behaviour in the rat. Exp Brain Res 32 (1978) 365-375
47. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281 (1998) 1640-1645
48. Kruk M.R., Van der Laan C.E., Meelis W., Phillips R.E., Mos J., and Van der Poel A.M. Brain-stimulation induced agonistic behaviour: a novel paradigm in ethopharmacological aggression research. Prog Clin Biol Res 167 (1984) 157-177
49. Kruk M.R., Van der Laan C.E., Mos J., Van der Poel A.M., Meelis W., and Olivier B. Comparison of aggressive behaviour induced by electrical stimulation in the hypothalamus of male and female rats. Prog Brain Res 61 (1984) 303-314
50. Kruk M.R., and van der Poel A.M. Is there evidence for a neural correlate of an aggressive behavioural system in the hypothalamus of the rat?. Prog Brain Res 53 (1980) 385-390
51. Kruk M.R., Van der Poel A.M., Meelis W., Hermans J., Mostert P.G., Mos J., et al. Discriminant analysis of the localization of aggression-inducing electrode placements in the hypothalamus of male rats. Brain Res 260 (1983) 61-79
52. Lammers J.H., Kruk M.R., Meelis W., and van der Poel A.M. Hypothalamic substrates for brain stimulation-induced attack, teeth-chattering and social grooming in the rat. Brain Res 449 (1988) 311-327
53. Lammers J.H., Kruk M.R., Meelis W., and van der Poel A.M. Hypothalamic substrates for brain stimulation-induced patterns of locomotion and escape jumps in the rat. Brain Res 449 (1988) 294-310
54. Lammers J.H., Meelis W., Kruk M.R., and van der Poel A.M. Hypothalamic substrates for brain stimulation-induced grooming, digging and circling in the rat. Brain Res 418 (1987) 1-19
55. Lammers J.H., van der Noordaa J., Kruk M.R., Meelis W., and van der Poel G.M. Interactions between simultaneously activated behavioral systems in the rat. Behav Neurosci 103 (1989) 784-789
56. Langevin H., and Emson P.C. Distribution of substance P, somatostatin and neurotensin in the human hypothalamus. Brain Res 246 (1982) 65-69
57. Ljungdahl A., Hökfelt T., and Nilsson G. Distribution of substance P-like immunoreactivity in the central nervous system of the rat: I. Cell bodies and nerve terminals. Neuroscience 3 (1978) 861-943
58. Maeno H., Kiyama H., and Tohyama M. Distribution of the substance P receptor (NK-1 receptor) in the central nervous system. Brain Res Mol Brain Res 18 (1993) 43-58
59. Mantyh P.W., Gates T., Mantyh C.R., and Maggio J.E. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J Neurosci 9 (1989) 258-279
60. Mantyh P.W., Hunt S.P., and Maggio J.E. Substance P receptors: localization by light microscopic autoradiography in rat brain using [3H]SP as the radioligand. Brain Res 307 (1984) 147-165
61. Marchand J.E., Shimonaka H., and Kream R.M. Biochemical characterization and anatomical distribution of a major form of unamidated precursor of substance P in rat brain. Brain Res 567 (1991) 290-305
62. Maubach K.A., Martin K., Smith D.W., Hewson L., Frankshun R.A., Harrison T., et al. Substance P stimulates inhibitory synaptic transmission in the guinea pig basolateral amygdala in vitro. Neuropharmacology 40 (2001) 806-817
63. McLean S., Ganong A.H., Seeger T.F., Bryce D.K., Pratt K.G., Reynolds L.S., et al. Activity and distribution of binding sites in brain of a nonpeptide substance P (NK1) receptor antagonist. Science 251 (1991) 437-439
64. Mos J., Kruk M.R., Van der Poel A.M., and Meelis W. Aggressive behavior induced by electrical stimulation in the midbrain central gray of male rats. Aggress Behav 8 (1982) 261-284
65. Moss M.S., and Basbaum A.I. The peptidergic organization of the cat periaqueductal gray: II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide. J Neurosci 3 (1983) 1437-1449
66. Nakaya Y., Kaneko T., Shigemoto R., Nakanishi S., and Mizuno N. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol 347 (1994) 249-274
67. Nelson R.J., and Chiavegatto S. Molecular basis of aggression. Trends Neurosci 24 (2001) 713-719
68. New A.S., Buchsbaum M.S., Hazlett E.A., Goodman M., Koenigsberg H.W., Lo J., et al. Fluoxetine increases relative metabolic rate in prefrontal cortex in impulsive aggression. Psychopharmacology (Berl) 176 (2004) 451-458
69. Nikulina E.M., Marchand J.E., Miczek K.A., and Kream R.M. Social defeat stress induces enhanced opioid analgesia and neurochemical changes in rat periaqueductal grey. Soc Neurosci Abstr 23 (1997) 126
70. 125I Bolton Hunter substance-P binding sites in human brain. Neurochem Int 18 3 (1991) 399-404
71. Olivier B., Olivier-Aardema R., and Wiepkema P.R. Effect of anterior hypothalamic and mammillary area lesions on territorial aggressive behaviour in male rats. Behav Brain Res 9 (1983) 59-81
72. Otsuka M., and Yoshioka K. Neurotransmitter functions of mammalian tachykinins. Physiol Rev 73 (1993) 229-308
73. Panksepp J. Aggression elicited by electrical stimulation of the hypothalamus in albino rats. Physiol Behav 6 (1971) 321-329
74. Panksepp J. Drugs and stimulus-bound attack. Physiol Behav 6 (1971) 317-320
75. Persson S., Le Grevés P., Thörnwall M., Eriksson U., Silberring J., and Nyberg F. Neuropeptide converting and processing enzymes in the spinal cord and cerebrospinal fluid. Prog Brain Res 104 (1995) 111-130
76. Peterson G.M., and Shurlow C.L. Morphological evidence for a substance P projection from medial septum to hippocampus. Peptides 13 (1992) 509-517
77. Quartara L., and Maggi C.A. The tachykinin NK1 receptor: Part II. Distribution and pathophysiological roles. Neuropeptides 32 (1998) 1-49
78. Ricciardi K.H., and Blaustein J.D. Projections from ventrolateral hypothalamic neurons containing progestin receptor- and substance P-immunoreactivity to specific forebrain and midbrain areas in female guinea pigs. J Neuroendocrinol 6 (1994) 135-144
79. Rosén A., Brodin K., Eneroth P., and Brodin E. Short-term restraint stress and s.c. saline injection alter the tissue levels of substance P and cholecystokinin in the peri-aqueductal grey and limbic regions of rat brain. Acta Physiol Scand 146 (1992) 341-348
80. Sakurada T., Katsuyama S., Sakurada S., Inoue M., Tan-No K., Kisara K., et al. Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors. Br J Pharmacol 127 (1999) 1712-1718
81. Sakurada T., Tan-No K., Yamada T., Sakurada S., and Kisara K. Phosphoramidon potentiates mammalian tachykinin-induced biting, licking and scratching behaviour in mice. Pharmacol Biochem Behav 37 (1990) 779-783
82. Sakurada T., Yamada T., Sakurada S., Kisara K., and Ohba M. Substance P analogues containing d-histidine antagonize the behavioural effects of intrathecally co-administered substance P in mice. Eur J Pharmacol 174 (1989) 153-160
83. Santarelli L., Gobbi G., Debs P.C., Sibille E.T., Blier P., Hen R., et al. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci USA 98 (2001) 1912-1917
84. Shaikh M.B., Steinberg A., and Siegel A. Evidence that substance P is utilized in medial amygdaloid facilitation of defensive rage behavior in the cat. Brain Res 625 (1993) 283-294
85. Siegel A. The neurobiology of aggression and rage (2005), CRC Press, Boca Raton, FL
86. Siegel A., Bhatt S., Bhatt R., and Zalcman S.S. The neurobiological bases for development of pharmacological treatments of aggressive disorders. Curr Neuropharmacol 5 (2007) 135-147
87. Siegel A., Edinger H., and Dotto M. Effects of electrical stimulation of the lateral aspect of the prefrontal cortex upon attack behavior in cats. Brain Res 93 (1975) 473-484
88. Siegel A., and Pott C.B. Neural substrates of aggression and flight in the cat. Prog Neurobiol 31 (1988) 261-283
89. Siegel A., Roeling T.A., Gregg T.R., and Kruk M.R. Neuropharmacology of brain-stimulation-evoked aggression. Neurosci Biobehav Rev 23 (1999) 359-389
90. Siegel A., Schubert K., and Shaikh M.B. Neurochemical mechanisms underlying amygdaloid modulation of aggressive behavior in the cat. Aggress Behav 21 (1995) 49-62
91. Smith G.S., Savery D., Marden C., López Costa J.J., Averill S., Priestley J.V., et al. Distribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene-related peptide in the midbrain periaqueductal grey in the rat. J Comp Neurol 350 (1994) 23-40
92. Teixeira R.M., Duarte F.S., and De Lima T.C. Behavioral and immunological effects of substance P in female and male mice. Pharmacol Biochem Behav 79 (2004) 1-9
93. Teixeira R.M., Santos A.R., Ribeiro S.J., Calixto J.B., Rae G.A., and De Lima T.C. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur J Pharmacol 311 (1996) 7-14
94. Vassout A., Veenstra S., Hauser K., Ofner S., Brugger F., Schilling W., et al. NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats. Regul Pept 96 (2000) 7-16
95. Warden M.K., and Young III W.S. Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system. J Comp Neurol 272 (1988) 90-113
96. Whitty C.J., Walker P.D., Goebel D.J., Poosch M.S., and Bannon M.J. Quantitation, cellular localization and regulation of neurokinin receptor gene expression within the rat substantia nigra. Neuroscience 64 (1995) 419-425
97. Woodworth C.H. Attack elicited in rats by electrical stimulation of the lateral hypothalamus. Physiol Behav 6 (1971) 345-353
98. Yao R., Rameshwar P., Donnelly R.J., and Siegel A. Neurokinin-1 expression and co-localization with glutamate and GABA in the hypothalamus of the cat. Brain Res Mol Brain Res 71 (1999) 149-158
99. Yip J., and Chahl L.A. Localization of NK1 and NK3 receptors in guinea-pig brain. Regul Pept 98 (2001) 55-62