Differential effects of NK1 receptors in the midbrain periaqueductal gray upon defensive rage and predatory attack in the cat

Brain Research

Volumn 994, Issue 1, 2003, Pages 55-66

  Gregg, Thomas R ^a   Siegel, Allan ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Attack; Defense; Emotion; Intracerebral; Limbic; Receptor

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; NEUROKININ 1 RECEPTOR; PHYSALAEMIN[9 DEXTRO PROLINE SPIRO GAMMA LACTAM 10 LEUCINE 11 TRYPTOPHAN]; PROTEIN C FOS; PROTEIN FOS; SUBSTANCE P; TACHYKININ RECEPTOR AGONIST; TACHYKININ RECEPTOR ANTAGONIST; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT;

AGGRESSIVENESS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DEFENSE MECHANISM; DRUG INHIBITION; ELECTRODE; FEMALE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MESENCEPHALON; MICROINJECTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PREDATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; RAGE; RECEPTOR INTRINSIC ACTIVITY; ANIMAL; CAT; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PHYSIOLOGY;

ANIMALS; CATS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MESENCEPHALON; PERIAQUEDUCTAL GRAY; PREDATORY BEHAVIOR; RAGE; RECEPTORS, NEUROKININ-1;

EID: 0344875106     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2003.09.024     Document Type: Article

References (41)

1. Aguiar M.S., Brandao M.L. Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test. Physiol. Behav. 60:1996;1183-1186.
2. Bandler R. Induction of 'rage' following microinjections of glutamate into midbrain but not hypothalamus of cats. Neurosci. Lett. 30:1982;183-188.
3. Barbaresi P. Immunocytochemical localization of substance P receptor in rat periaqueductal gray matter: a light and electron microscopic study. J. Comp. Neurol. 398:1998;473-490.
4. Bard P. A Diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system. Am. J. Physiol. 84:1928;490-515.
5. Bhatt S., Gregg T.R., Siegel A. NK1 receptors in the medial hypothalamus potentiate defensive rage behavior elicited from the midbrain periaqueductal gray of the cat. Brain Res. 966:2003;54-64.
6. Cheu J.W., Siegel A. GABA receptor mediated suppression of defensive rage behavior elicited from the medial hypothalamus of the cat: role of the lateral hypothalamus. Brain Res. 783:1998;293-304.
7. Chi C.C., Flynn J.P. Neural pathways associated with hypothalamically elicited attack behavior in cats. Science. 171:1971;703-706.
8. De Araújo J.E., Huston J.P., Brandao M.L. Opposite effects of substance P fragments C (anxiogenic) and N (anxiolytic) injected into dorsal periaqueductal gray. Eur. J. Pharmacol. 432:2001;43-51.
9. 1 receptors. Peptides. 22:2001;1447-1452.
10. Fuchs S.A.G., Edinger H.M., Siegel A. The organization of the hypothalamic pathways mediating affective defense behavior in the cat. Brain Res. 330:1985;77-92.
11. Fuchs S.A.G., Edinger H.M., Siegel A. The role of the anterior hypothalamus in affective defense behavior elicited from the ventromedial hypothalamus of the cat. Brain Res. 330:1985;93-108.
12. Gallagher A.W., Chahl L.A., Lynch A.M. Distribution of substance P-like immunoreactivity in guinea pig central nervous system. Brain Res. Bull. 29:1992;199-207.
13. Gavioli E.C., Canteras N.S., De Lima T.C.M. The role of lateral septal NK1 receptors in mediating anxiogenic effects induced by intracerebroventricular injection of substance P. Behav. Brain Res. 134:2002;411-415.
14. Gentsch C., Cutler M., Vassout A., Veenstra S., Brugger F. Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils. Behav. Brain Res. 133:2002;363-368.
15. Gerrits P.O., Croon D.H., Holstege G. A new subdivision of the rat midbrain periaqueductal gray based on its myeloarchitecture. Neurosci. Lett. 161:1993;232-236.
16. Gioia M., Bianchi R. Ultrastructure of substance P immunoreactive elements in the periaqueductal gray matter of the rat. Anat. Rec. 228:1990;345-357.
17. Gregg T.R. Cortical and limbic neural circuits mediating aggressive behavior. Mattson M.P. Neurobiology of Aggression: Understanding and Preventing Violence. 2003;1-20 Humana Press, Totowa, New Jersey, USA.
18. Gregg T.R., Siegel A. Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression. Prog. Neuro-psychopharmacol. Biol. Psychiatry. 25:2001;91-140.
19. 2 receptor antagonist on emotional processes in rodents. Psychopharmacology (Berl.). 158:2001;241-251.
20. Han Y., Shaikh M.B., Siegel A. Medial amygdaloid suppression of predatory attack behavior in the cat: I. Role of a substance P pathway from the medial amygdala to the medial hypothalamus. Brain Res. 716:1996;59-71.
21. Han Y., Shaikh M.B., Siegel A. Medial amygdaloid suppression of predatory attack behavior in the cat: II. Role of a GABAergic pathway from the medial to the lateral hypothalamus. Brain Res. 716:1996;72-83.
22. Hunsperger R.W. Role of substantia grisea centralis mesencephali in electrically-induced rage reactions. Kappers J. Progress in Neurobiology. 1956;289-294 Elsevier, New York.
23. Jasper H.H., Ajmone-Marsan C.A. Stereotaxic Atlas of the Diencephalon of the Cat. 1954;National Research Council of Canada, Ottawa.
24. Keller A.D. Autonomic discharges elicited by physiological stimuli in mid-brain preparations. Am. J. Physiol. 100:1932;576-586.
25. Le Gal La Salle G., Ben-Ari Y. Microiontophoretic effects of substance P on neurons of the medial amygdala and putamen of the rat. Brain Res. 135(1):1977;174-179.
26. Lu C.L., Shaikh M.B., Siegel A. Role of NMDA receptors in hypothalamic facilitation of feline defensive rage elicited from the midbrain periaqueductal gray. Brain Res. 581:1992;123-132.
27. Mayer M.L., MacLeod N.K. The excitatory action of substance P and stimulation of the stria terminalis bed nucleus on preoptic neurones. Brain Res. 166(1):1979;206-210.
28. Moss M.S., Basbaum A.I. The peptidergic organization of the cat periaqueductal gray: II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide. J. Neurosci. 3(7):1983;1437-1449.
29. Nicoll R.A., Alger B.E., Jahr C.E. Peptides as putative excitatory neurotransmitters: carnosine, enkephalin, substance P and TRH. Proc. R. Soc. Lond., B Biol. Sci. 210:1980;133-149.
30. Ranga K., Krishnan R. Clinical experience with substance P receptor (NK1) antagonists in depression. J. Clin. Psychiatry. 63(Suppl. 11):2002;25-29.
31. Ribeiro R.L., De Lima T.C. Participation of GABAA receptors in the modulation of experimental anxiety by tachykinin agonists and antagonists in mice. Prog. Neuro-psychopharmacol. Biol. Psychiatry. 26:2002;861-869.
32. Rosén A., Brodin K., Eneroth P., Brodin E. Short-term restraint stress and s.c. saline injection alter the tissue levels of substance P and cholecystokinin in the peri-aqueductal grey and limbic regions of rat brain. Acta Physiol. Scand. 146:1992;341-348.
33. Schubert K., Shaikh M.B., Siegel A. NMDA receptors in the midbrain periaqueductal gray mediate hypothalamically evoked hissing behavior in the cat. Brain Res. 726:1996;80-90.
34. Shaikh M.B., Barrett J.A., Siegel A. The pathways mediating affective defense and quiet biting attack behavior from the midbrain central gray of the cat: an autoradiographic study. Brain Res. 437:1987;9-25.
35. Shaikh M.B., Steinberg A., Siegel A. Evidence that substance P is utilized in medial amygdaloid facilitation of defensive rage behavior in the cat. Brain Res. 625:1993;283-294.
36. Siegel A., Brutus M. Neural substrates of aggression and rage in the cat. Epstein A.N., Morrison A.R. Progress in Psychobiology and Physiological Psychology. vol. 14:1990;135-233 Academic Press, San Diego, CA.
37. Siegel A., Roeling T.A.P., Gregg T.R., Kruk M.R. Neuropharmacology of brain-stimulation-evoked aggression. Neurosci. Biobehav. Rev. 23:1999;359-389.
38. Teixeira R.M., Santos A.R.S., Ribeiro S.J., Calixto J.B., Rae G.A., De Lima T.C.M. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur. J. Pharmacol. 311:1996;7-14.
39. Tsunoo A., Konishi S., Otsuka M. Substance P as an excitatory transmitter of primary afferent neurons in guinea-pig sympathetic ganglia. Neuroscience. 7:1982;2025-2037.
40. Varty G.B., Cohen-Williams M.E., Morgan C.A., Pylak U., Duffy R.A., Lachowicz J.E., Carey G.J., Coffin V.L. The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists. Neuropsychopharmacology. 27:2002;371-379.
41. 3 receptors in guinea-pig brain. Regulatory Pept. 98:2001;55-62.