Promotion of skin graft tolerance across MHC barriers by mobilization of dendritic cells in donor hemopoietic cell infusions

Journal of Immunology

Volumn 169, Issue 5, 2002, Pages 2390-2396

  Eto, Masatoshi ^a   Hackstein, Holger ^a   Kaneko, Katsuhiko ^a   Nomoto, Kikuo ^a   Thomson, Angus W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; FLT3 LIGAND; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CHIMERA; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEMATOPOIETIC CELL; HLA MATCHING; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; SKIN TRANSPLANTATION; SPLEEN CELL;

EID: 0036721798     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.5.2390     Document Type: Article

References (32)

1. Immunobiology of dendritic cells
2. Migration of dendritic leukocytes from cardiac allografts into host spleens: A novel pathway for initiation of rejection
3. -) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes
4. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
5. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
6. -) prolong cardiac allograft survival in nonimmunosuppressed recipients
7. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo
8. + dendritic cells prolong the survival of vascularized heart allografts
9. Dendritic cell tolerogenicity and prospects for dendritic cell-based therapy of allograft rejection and autoimmune disease
10. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: Long-term survival of allogeneic bone marrow and skin grafts
11. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts
12. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen
13. + T cells in cyclophosphamide-induced tolerance to H-2-compatible, Mis-disparate antigens
14. The requirement of intrathymic mixed chimerism and clonal deletion for a long-lasting skin allograft tolerance in cyclophosphamide-induced tolerance
15. Mechanisms of cyclophosphamide-induced tolerance to IE-encoded alloantigens: Evidence of clonal deletion in MHC antigen-reactive cells for skin allograft rejection
16. Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity
17. Flt-3 ligand increases microchimerism but can prevent the therapeutic effect of donor bone marrow in transiently immunosuppressed cardiac allograft recipients
18. Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: Multiple dendritic cell subpopulations identified
19. Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: Modulation by tacrolimus
20. Aspirin inhibits in vitro maturation and in vivo immunostimulatory function of murine myeloid dendritic cells
21. A surgical technique for experimental free skin grafting in mice
22. Induction of permanent mixed chimerism and skin allograft tolerance across fully MHC-mismatched barriers by the additional myelosuppressive treatments in mice primed with allogeneic spleen cells followed by cyclophosphamide
23. Prolongation of kidney graft survival by cyclophosphamide-induced tolerance in rats
24. Drug-induced tolerance to allografts in mice X. Augmentation of split tolerance in murine combinations disparate at both H-2 and non-H-2 antigens by the use of spleen cells from donors preimmunized with recipient antigens
25. Cyclophosphamide-induced tolerance in rat orthotopic liver transplantation
26. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning
27. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance
28. Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression
29. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
30. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
31. Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival
32. Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb