The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen

Molecular and Biochemical Parasitology

Volumn 167, Issue 1, 2009, Pages 41-47

  Corvo, Ileana ^a   Cancela, Martín ^b   Cappetta, Mónica ^a   Pi Denis, Natalia ^a   Tort, José F ^a   Roche, Leda ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Cathepsins; Collagenase; Fasciola hepatica NEJ; Hansenula polymorpha; Invasion; Trematode

Indexed keywords

CATHEPSIN K; CATHEPSIN L; COLLAGEN; COLLAGEN TYPE 1; CYSTEINE PROTEINASE; IMMUNOGLOBULIN G1; PROLINE; CATHEPSIN; HELMINTH DNA;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVE SITE; FASCIOLA HEPATICA; FUNGUS CULTURE; HANSENULA POLYMORPHA; HOST PARASITE INTERACTION; HYDROPHOBICITY; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN STRUCTURE; TEMPERATURE SENSITIVITY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; ENZYME STABILITY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; PH; PICHIA; PROTEIN TERTIARY STRUCTURE; TEMPERATURE;

FASCIOLA HEPATICA; MAMMALIA; PICHIA ANGUSTA; TREMATODA;

ANIMALS; CATALYTIC DOMAIN; CATHEPSINS; COLLAGEN; CYSTEINE ENDOPEPTIDASES; DNA, HELMINTH; ENZYME STABILITY; FASCIOLA HEPATICA; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PICHIA; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, DNA; TEMPERATURE;

EID: 67650401426     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.04.005     Document Type: Article

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