-
1
-
-
34250857019
-
Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis
-
Langley RR, Fidler IJ (2007) Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis. Endocr Rev 28: 297-321.
-
(2007)
Endocr Rev
, vol.28
, pp. 297-321
-
-
Langley, R.R.1
Fidler, I.J.2
-
2
-
-
34948896045
-
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
-
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, et al. (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449: 557-563.
-
(2007)
Nature
, vol.449
, pp. 557-563
-
-
Karnoub, A.E.1
Dash, A.B.2
Vo, A.P.3
Sullivan, A.4
Brooks, M.W.5
-
3
-
-
34247269026
-
Genetic determinants of cancer metastasis
-
Nguyen DX, Massague J (2007) Genetic determinants of cancer metastasis. Nat Rev Genet 8: 341-352.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 341-352
-
-
Nguyen, D.X.1
Massague, J.2
-
4
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, et al. (2007) LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
-
5
-
-
56349098933
-
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
-
Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, et al. (2008) Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135: 865-878.
-
(2008)
Cell
, vol.135
, pp. 865-878
-
-
Zhan, L.1
Rosenberg, A.2
Bergami, K.C.3
Yu, M.4
Xuan, Z.5
-
6
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, et al. (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
-
7
-
-
58149269348
-
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
-
Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, et al. (2009) Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature 457: 102-106.
-
(2009)
Nature
, vol.457
, pp. 102-106
-
-
Kim, S.1
Takahashi, H.2
Lin, W.W.3
Descargues, P.4
Grivennikov, S.5
-
8
-
-
35148886434
-
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
-
Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688.
-
(2007)
Nature
, vol.449
, pp. 682-688
-
-
Ma, L.1
Teruya-Feldstein, J.2
Weinberg, R.A.3
-
9
-
-
38049115129
-
Endogenous human microRNAs that suppress breast cancer metastasis
-
Tavazoie SF, Alarcon C, Oskarsson T, Padua D, Wang Q, et al. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451: 147-152.
-
(2008)
Nature
, vol.451
, pp. 147-152
-
-
Tavazoie, S.F.1
Alarcon, C.2
Oskarsson, T.3
Padua, D.4
Wang, Q.5
-
10
-
-
0034036430
-
Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein
-
Kerkhoff E, Fedorov LM, Siefken R, Walter AO, Papadopoulos T, et al. (2000) Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Differ 11: 185-190.
-
(2000)
Cell Growth Differ
, vol.11
, pp. 185-190
-
-
Kerkhoff, E.1
Fedorov, L.M.2
Siefken, R.3
Walter, A.O.4
Papadopoulos, T.5
-
11
-
-
34547609385
-
Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer
-
Ceteci F, Ceteci S, Karreman C, Kramer BW, Asan E, et al. (2007) Disruption of tumor cell adhesion promotes angiogenic switch and progression to micrometastasis in RAF-driven murine lung cancer. Cancer Cell 12: 145-159.
-
(2007)
Cancer Cell
, vol.12
, pp. 145-159
-
-
Ceteci, F.1
Ceteci, S.2
Karreman, C.3
Kramer, B.W.4
Asan, E.5
-
12
-
-
34547730818
-
-
PLoS
-
Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, et al. (2007) Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4. PLoS ONE 2: e426.
-
(2007)
Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4
, vol.ONE 2
-
-
Marks, J.L.1
McLellan, M.D.2
Zakowski, M.F.3
Lash, A.E.4
Kasai, Y.5
-
13
-
-
0032541671
-
Cell cycle targets of Ras/Raf signalling
-
Kerkhoff E, Rapp UR (1998) Cell cycle targets of Ras/Raf signalling. Oncogene 17: 1457-1462.
-
(1998)
Oncogene
, vol.17
, pp. 1457-1462
-
-
Kerkhoff, E.1
Rapp, U.R.2
-
15
-
-
38349168094
-
Oncogene-induced plasticity and cancer stem cells
-
Rapp UR, Ceteci F, Schreck R (2008) Oncogene-induced plasticity and cancer stem cells. Cell Cycle 7: 45-51.
-
(2008)
Cell Cycle
, vol.7
, pp. 45-51
-
-
Rapp, U.R.1
Ceteci, F.2
Schreck, R.3
-
16
-
-
0023938578
-
Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes
-
Yokota J, Wada M, Yoshida T, Noguchi M, Terasaki T, et al. (1988) Heterogeneity of lung cancer cells with respect to the amplification and rearrangement of myc family oncogenes. Oncogene 2: 607-611.
-
(1988)
Oncogene
, vol.2
, pp. 607-611
-
-
Yokota, J.1
Wada, M.2
Yoshida, T.3
Noguchi, M.4
Terasaki, T.5
-
17
-
-
34948852371
-
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
-
Soucek L, Lawlor ER, Soto D, Shchors K, Swigart LB, et al. (2007) Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nat Med 13: 1211-1218.
-
(2007)
Nat Med
, vol.13
, pp. 1211-1218
-
-
Soucek, L.1
Lawlor, E.R.2
Soto, D.3
Shchors, K.4
Swigart, L.B.5
-
18
-
-
47749121455
-
-
PLoS
-
Tran PT, Fan AC, Bendapudi PK, Koh S, Komatsubara K, et al. (2008) Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas. PLoS ONE 3: e2125.
-
(2008)
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas
, vol.ONE 3
-
-
Tran, P.T.1
Fan, A.C.2
Bendapudi, P.K.3
Koh, S.4
Komatsubara, K.5
-
19
-
-
56849093474
-
Distinct thresholds govern Myc's biological output in vivo
-
Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, et al. (2008) Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14: 447-457.
-
(2008)
Cancer Cell
, vol.14
, pp. 447-457
-
-
Murphy, D.J.1
Junttila, M.R.2
Pouyet, L.3
Karnezis, A.4
Shchors, K.5
-
20
-
-
49449105336
-
Lung epithelial progenitor cells: Lessons from development
-
Rawlins EL (2008) Lung epithelial progenitor cells: lessons from development. Proc Am Thorac Soc 5: 675-681.
-
(2008)
Proc Am Thorac Soc
, vol.5
, pp. 675-681
-
-
Rawlins, E.L.1
-
21
-
-
0021819762
-
Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus
-
Rapp UR, Cleveland JL, Fredrickson TN, Holmes KL, Morse HC, 3rd, et al. (1985) Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol 55: 23-33.
-
(1985)
J Virol
, vol.55
, pp. 23-33
-
-
Rapp, U.R.1
Cleveland, J.L.2
Fredrickson, T.N.3
Holmes, K.L.4
Morse 3rd, H.C.5
-
22
-
-
0037040178
-
GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression
-
Liu C, Glasser SW, Wan H, Whitsett JA (2002) GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem 277: 4519-4525.
-
(2002)
J Biol Chem
, vol.277
, pp. 4519-4525
-
-
Liu, C.1
Glasser, S.W.2
Wan, H.3
Whitsett, J.A.4
-
23
-
-
20444397431
-
Identification of bronchioalveolar stem cells in normal lung and lung cancer
-
Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, et al. (2005) Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121: 823-835.
-
(2005)
Cell
, vol.121
, pp. 823-835
-
-
Kim, C.F.1
Jackson, E.L.2
Woolfenden, A.E.3
Lawrence, S.4
Babar, I.5
-
24
-
-
0035923616
-
Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation
-
Krane CM, Fortner CN, Hand AR, McGraw DW, Lorenz JN, et al. (2001) Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proc Natl Acad Sci U S A 98: 14114-14119.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 14114-14119
-
-
Krane, C.M.1
Fortner, C.N.2
Hand, A.R.3
McGraw, D.W.4
Lorenz, J.N.5
-
25
-
-
46249128798
-
Bmi1 is expressed in vivo in intestinal stem cells
-
Sangiorgi E, Capecchi MR (2008) Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40: 915-920.
-
(2008)
Nat Genet
, vol.40
, pp. 915-920
-
-
Sangiorgi, E.1
Capecchi, M.R.2
-
26
-
-
0034609818
-
Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
-
Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A (2000) Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature 407: 592-598.
-
(2000)
Nature
, vol.407
, pp. 592-598
-
-
Lasorella, A.1
Noseda, M.2
Beyna, M.3
Yokota, Y.4
Iavarone, A.5
-
27
-
-
0037025173
-
Cancer. Addiction to oncogenes-the Achilles heal of cancer
-
Weinstein IB (2002) Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297: 63-64.
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
28
-
-
5644275143
-
Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium
-
Russell RG, Lasorella A, Dettin LE, Iavarone A (2004) Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium. Cancer Res 64: 7220-7225.
-
(2004)
Cancer Res
, vol.64
, pp. 7220-7225
-
-
Russell, R.G.1
Lasorella, A.2
Dettin, L.E.3
Iavarone, A.4
-
29
-
-
29244476917
-
Filtering transcriptional noise during development: Concepts and mechanisms
-
Arias AM, Hayward P (2006) Filtering transcriptional noise during development: concepts and mechanisms. Nat Rev Genet 7: 34-44.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 34-44
-
-
Arias, A.M.1
Hayward, P.2
-
30
-
-
64149118533
-
-
PLoS
-
Becker M, Korn C, Sienerth AR, Voswinckel R, Luetkenhaus K, et al. (2009) Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer. PLoS ONE 4: e4230.
-
(2009)
Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer
, vol.ONE 4
-
-
Becker, M.1
Korn, C.2
Sienerth, A.R.3
Voswinckel, R.4
Luetkenhaus, K.5
-
31
-
-
4644313271
-
c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism
-
Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL (2004) c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res 64: 6563-6570.
-
(2004)
Cancer Res
, vol.64
, pp. 6563-6570
-
-
Knies-Bamforth, U.E.1
Fox, S.B.2
Poulsom, R.3
Evan, G.I.4
Harris, A.L.5
-
32
-
-
0032888057
-
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer
-
Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, et al. (1999) PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 155: 711-715.
-
(1999)
Am J Pathol
, vol.155
, pp. 711-715
-
-
Hibi, K.1
Westra, W.H.2
Borges, M.3
Goodman, S.4
Sidransky, D.5
-
33
-
-
35148859639
-
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation
-
Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, et al. (2007) Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation. Arterioscler Thromb Vasc Biol 27: 2184-2190.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 2184-2190
-
-
Takami, Y.1
Nakagami, H.2
Morishita, R.3
Katsuya, T.4
Cui, T.X.5
-
34
-
-
54749146365
-
Tube travel: The role of proteases in individual and collective cancer cell invasion
-
Friedl P, Wolf K (2008) Tube travel: the role of proteases in individual and collective cancer cell invasion. Cancer Res 68: 7247-7249.
-
(2008)
Cancer Res
, vol.68
, pp. 7247-7249
-
-
Friedl, P.1
Wolf, K.2
-
35
-
-
45549086246
-
LKB1 and lung cancer: More than the usual suspects
-
Shah U, Sharpless NE, Hayes DN (2008) LKB1 and lung cancer: more than the usual suspects. Cancer Res 68: 3562-3565.
-
(2008)
Cancer Res
, vol.68
, pp. 3562-3565
-
-
Shah, U.1
Sharpless, N.E.2
Hayes, D.N.3
-
36
-
-
0027457349
-
Oncogene activation: C-raf-1 gene mutations in experimental and naturally occurring tumors
-
Storm SM, Rapp UR (1993) Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors. Toxicol Lett 67: 201-210.
-
(1993)
Toxicol Lett
, vol.67
, pp. 201-210
-
-
Storm, S.M.1
Rapp, U.R.2
-
37
-
-
33645683121
-
Is BRAF the Achilles' Heel of thyroid cancer?
-
Chiloeches A, Marais R (2006) Is BRAF the Achilles' Heel of thyroid cancer? Clin Cancer Res 12: 1661-1664.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1661-1664
-
-
Chiloeches, A.1
Marais, R.2
-
38
-
-
46249127489
-
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
-
Zhang Y, Goss AM, Cohen ED, Kadzik R, Lepore JJ, et al. (2008) A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet 40: 862-870.
-
(2008)
Nat Genet
, vol.40
, pp. 862-870
-
-
Zhang, Y.1
Goss, A.M.2
Cohen, E.D.3
Kadzik, R.4
Lepore, J.J.5
-
39
-
-
8444227379
-
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells
-
van der Sluis M, Melis MH, Jonckheere N, Ducourouble MP, Buller HA, et al. (2004) The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem Biophys Res Commun 325: 952-960.
-
(2004)
Biochem Biophys Res Commun
, vol.325
, pp. 952-960
-
-
van der Sluis, M.1
Melis, M.H.2
Jonckheere, N.3
Ducourouble, M.P.4
Buller, H.A.5
-
40
-
-
0021720781
-
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes
-
Stewart TA, Pattengale PK, Leder P (1984) Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 38: 627-637.
-
(1984)
Cell
, vol.38
, pp. 627-637
-
-
Stewart, T.A.1
Pattengale, P.K.2
Leder, P.3
-
41
-
-
0026056967
-
Pancreatic tumor pathogenesis reflects the causative genetic lesion
-
Sandgren EP, Quaife CJ, Paulovich AG, Palmiter RD, Brinster RL (1991) Pancreatic tumor pathogenesis reflects the causative genetic lesion. Proc Natl Acad Sci U S A 88: 93-97.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 93-97
-
-
Sandgren, E.P.1
Quaife, C.J.2
Paulovich, A.G.3
Palmiter, R.D.4
Brinster, R.L.5
-
42
-
-
33748693361
-
Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice
-
Liao DJ, Wang Y, Wu J, Adsay NV, Grignon D, et al. (2006) Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic mice. J Carcinog 5: 19.
-
(2006)
J Carcinog
, vol.5
, pp. 19
-
-
Liao, D.J.1
Wang, Y.2
Wu, J.3
Adsay, N.V.4
Grignon, D.5
-
43
-
-
53349103292
-
Modelling Myc inhibition as a cancer therapy
-
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, et al. (2008) Modelling Myc inhibition as a cancer therapy. Nature 455: 679-683.
-
(2008)
Nature
, vol.455
, pp. 679-683
-
-
Soucek, L.1
Whitfield, J.2
Martins, C.P.3
Finch, A.J.4
Murphy, D.J.5
-
44
-
-
0035924702
-
Id proteins at the cross-road of development and cancer
-
Lasorella A, Uo T, Iavarone A (2001) Id proteins at the cross-road of development and cancer. Oncogene 20: 8326-8333.
-
(2001)
Oncogene
, vol.20
, pp. 8326-8333
-
-
Lasorella, A.1
Uo, T.2
Iavarone, A.3
-
45
-
-
42049084004
-
Maintenance and repair of the bronchiolar epithelium
-
Stripp BR, Reynolds SD (2008) Maintenance and repair of the bronchiolar epithelium. Proc Am Thorac Soc 5: 328-333.
-
(2008)
Proc Am Thorac Soc
, vol.5
, pp. 328-333
-
-
Stripp, B.R.1
Reynolds, S.D.2
-
46
-
-
0038036832
-
Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch
-
Fedorov LM, Papadopoulos T, Tyrsin OY, Twardzik T, Gotz R, et al. (2003) Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. Cancer Res 63: 2268-2277.
-
(2003)
Cancer Res
, vol.63
, pp. 2268-2277
-
-
Fedorov, L.M.1
Papadopoulos, T.2
Tyrsin, O.Y.3
Twardzik, T.4
Gotz, R.5
-
47
-
-
23844476499
-
p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest
-
Ho JS, Ma W, Mao DY, Benchimol S (2005) p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol 25: 7423-7431.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7423-7431
-
-
Ho, J.S.1
Ma, W.2
Mao, D.Y.3
Benchimol, S.4
-
48
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV (2007) Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol Cell Biol 27: 7381-7393.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
49
-
-
0036460782
-
Renilla luciferase-Aequorea GFP (Ruc-GFP) fusion protein, a novel dual reporter for real-time imaging of gene expression in cell cultures and in live animals
-
Wang Y, Yu YA, Shabahang S, Wang G, Szalay AA (2002) Renilla luciferase-Aequorea GFP (Ruc-GFP) fusion protein, a novel dual reporter for real-time imaging of gene expression in cell cultures and in live animals. Mol Genet Genomics 268: 160-168.
-
(2002)
Mol Genet Genomics
, vol.268
, pp. 160-168
-
-
Wang, Y.1
Yu, Y.A.2
Shabahang, S.3
Wang, G.4
Szalay, A.A.5
|