The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells

DMM Disease Models and Mechanisms

Volumn 2, Issue 5-6, 2009, Pages 306-312

  King, Jason S ^a,d   Teo, Regina ^a   Ryves, Jonathan ^a   Reddy, Jonathan V ^a   Peters, Owen ^a   Orabi, Ben ^b   Hoeller, Oliver ^c   Williams, Robin S B ^b   Harwood, Adrian J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL PHOSPHATE; LITHIUM; MOOD STABILIZER; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; TRANQUILIZER;

ARTICLE; CHEMOTAXIS; DICTYOSTELIUM; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; ANIMAL; CELL STRAIN HL 60; CYTOLOGY; DRUG EFFECT; METABOLISM; SIGNAL TRANSDUCTION;

DICTYOSTELIUM;

ANIMALS; ANTIMANIC AGENTS; CHEMOTAXIS; DICTYOSTELIUM; HL-60 CELLS; HUMANS; LITHIUM; PHOSPHATIDYLINOSITOL PHOSPHATES; SIGNAL TRANSDUCTION;

EID: 67650317803     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.001271     Document Type: Article

References (54)

1. Andrew, N. and Insall, R. H. (2007). Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions. Nat. Cell Biol. 9, 193-200. (Pubitemid 46420862)
2. Atack, J. R., Broughton, H. B. and Pollack, S. J. (1995). Structure and mechanism of inositol monophosphatase. FEBS Lett. 361, 1-7.
3. Backman, S. A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J., Tsao, M. S., Shannon, P., Bolon, B., Ivy, G. O. et al. (2001). Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat. Genet. 29, 396-403. (Pubitemid 34326689)
4. Barber, M. A. and Welch, H. C. (2006). PI3K and RAC signalling in leukocyte and cancer cell migration. Bull. Cancer 93, E44-E52.
5. Berridge, M. J. (1985). Phosphoinositides and signal transductions. Rev. Clin. Basic Pharm. 5 Suppl., 5S-13S.
6. Burgess, S., Geddes, J., Hawton, K., Townsend, E., Jamison, K. and Goodwin, G. (2001). Lithium for maintenance treatment of mood disorders. Cochrane Database Syst. Rev. CD003013.
7. Carter, C. J. (2007). Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability. Neurochem. Int. 50, 461-490.
8. Chadborn, N. H., Ahmed, A. I., Holt, M. R., Prinjha, R., Dunn, G. A., Jones, G. E. and Eickholt, B. J. (2006). PTEN couples Sema3A signalling to growth cone collapse. J. Cell Sci. 119, 951-957.
9. Chilvers, E. R., Batty, I. H., Challiss, R. A., Barnes, P. J. and Nahorski, S. R. (1991). Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle. Biochem. J. 275, 373-379.
10. Collins, S. J., Ruscetti, F. W., Gallagher, R. E. and Gallo, R. C. (1979). Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. J. Exp. Med. 149, 969-974.
11. Craddock, N. and Jones, I. (1999). Genetics of bipolar disorder. J. Med. Genet. 36, 585-594.
12. Cui, Y. D., Inanami, O., Yamamori, T., Niwa, K., Nagahata, H. and Kuwabara, M. (2000). FMLP-induced formation of F-actin in HL60 cells is dependent on PI3-K but not on intracellular Ca2+, PKC, ERK or p38 MAPK. Inflamm. Res. 49, 684-691. (Pubitemid 32097084)
13. Das Gupta, R. and Guest, J. F. (2002). Annual cost of bipolar disorder to UK society. Br. J. Psychiatry 180, 227-233.
14. Drayer, A. L., Van der Kaay, J., Mayr, G. W. and Van Haastert, P. J. M. (1994). Role of phospholipase C in Dictyostelium-formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity. EMBO J. 13, 1601-1609.
15. Eng, C. (2003). PTEN: one gene, many syndromes. Hum. Mutat. 22, 183-198.
16. Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca, M. L., Lazzeri, G., Spalloni, A., Bellio, N., Lenzi, P. et al. (2008). Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 105, 2052-2057. (Pubitemid 351705154)
17. Funamoto, S., Meili, R., Lee, S., Parry, L. and Firtel, R. A. (2002). Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109, 611-623. (Pubitemid 34628724)
18. Gutiérrez-Rojas, L., Gurpegui, M., Ayuso-Mateos, J. L., Gutiérrez-Ariza, J. A., Ruiz-Veguilla, M. and Jurado, D. (2008). Quality of life in bipolar disorder patients: a comparison with a general population sample. Bipolar Disord. 10, 625-634. (Pubitemid 352003829)
19. Hall, A. L., Schlein, A. and Condeelis, J. (1988). Relationship of pseudopod extension to chemotactic hormone-induced actin polymerisation in amoeboid cells. J. Cell Biochem. 37, 285-299.
20. Hallcher, L. M. and Sherman, W. R. (1980). The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J. Biol. Chem. 255, 10896-10901.
21. Hoeller, O. and Kay, R. R. (2007). Chemotaxis in the absence of PIP3 gradients. Curr. Biol. 17, 813-817.
22. Iijima, M. and Devreotes, P. (2002). Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109, 599-610. (Pubitemid 34628723)
23. Janmey, P. A. and Lindberg, U. (2004). Cytoskeletal regulation: rich in lipids. Nat. Rev. Mol. Cell. Biol. 5, 658-666.
24. Kamimura, Y., Xiong, Y., Iglesias, P. A., Hoeller, O., Bolourani, P. and Devreotes, P. N. (2008). PIP(3)-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Curr. Biol. 18, 1034-1043.
25. Kessin, R. H. (2001). Dictyostelium: Evolution, Cell Biology, and The Development Of Multicellularity. Cambridge: Cambridge University Press.
26. Kortholt, A., King, J. S., Keizer-Gunnink, I., Harwood, A. J. and Van Haastert, P. J. (2007). Phospholipase C Regulation of Phosphatidylinositol 3,4,5-trisphosphatemediated Chemotaxis. Mol. Biol. Cell 18, 4772-4779. (Pubitemid 350246680)
27. Leslie, N. R. and Downes, C. P. (2004). PTEN function: how normal cells control it and tumour cells lose it. Biochem. J. 382, 1-11.
28. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R. et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 1943-1947. (Pubitemid 27148818)
29. Lim, C. J., Spiegelman, G. B. and Weeks, G. (2001). RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation. EMBO J. 20, 4490-4499.
30. Loovers, H. M., Postma, M., Keizer-Gunnink, I., Huang, Y. E., Devreotes, P. N. and van Haastert, P. J. (2006). Distinct roles of PI(3,4,5)P3 during chemoattractant signalling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Mol. Biol. Cell 17, 1503-1513. (Pubitemid 44011571)
31. Maeda, Y. (1970). Influence of ionic conditions on cell differentiation and morphogenesis of the cellular slime molds. Dev. Growth Differ. 12, 217-227.
32. Martin-Pena, A., Acebes, A., Rodriguez, J. R., Sorribes, A., de Polavieja, G. G., Fernandez-Funez, P. and Ferrus, A. (2006). Age-independent synaptogenesis by phosphoinositide 3 kinase. J. Neurosci. 26, 10199-10208.
33. Meili, R., Ellsworth, C. and Firtel, R. A. (2000). A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium. Curr. Biol. 10, 708-717. (Pubitemid 30437943)
34. Parent, C. A., Blacklock, B. J., Froehlich, W. M., Murphy, D. B. and Devreotes, P. N. (1998). G protein signalling events are activated at the leading edge of chemotactic cells. Cell 95, 81-91.
35. Pawolleck, N. and Williams, R. (2009). Quantifying in vivo phosphoinositide turnover in chemotactically-competent Dictyostelium cells. In Chemotaxis: Methods and Protocols (Methods in Molecular Biology) (ed. J. Tian and H. Dale). Totowa, NJ: Humana Press (in press).
36. Ramsey, M. M., Adams, M. M., Ariwodola, O. J., Sonntag, W. E. and Weiner, J. L. (2005). Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J. Neurophysiol. 94, 247-254.
37. Sarkar, S., Floto, R. A., Berger, Z., Imarisio, S., Cordenier, A., Pasco, M., Cook, L. J. and Rubinsztein, D. C. (2005). Lithium induces autophagy by inhibiting inositol monophosphatase. J. Cell Biol. 170, 1101-1111. (Pubitemid 41362642)
38. Servant, G., Weiner, O. D., Herzmark, P., Balla, T., Sedat, J. W. and Bourne, H. R. (2000). Polarization of chemoattractant receptor signalling during neutrophil chemotaxis. Science 287, 1037-1040. (Pubitemid 30094359)
39. Shaltiel, G., Shamir, A., Shapiro, J., Ding, D., Dalton, E., Bialer, M., Harwood, A. J., Belmaker, R. H., Greenberg, M. L. and Agam, G. (2004). Valproate decreases inositol biosynthesis. Biol. Psychiatry 56, 868-874.
40. Shimshoni, J. A., Dalton, E. C., Jenkins, A., Eyal, S., Ewan, K., Williams, R. S., Pessah, N., Yagen, B., Harwood, A. J. and Bialer, M. (2007). The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Mol. Pharmacol. 71, 884-892. (Pubitemid 46294100)
41. Shimshoni, J. A., Dalton, E. C., Yagenc, B., Bialer, M. and Harwood, A. J. (2009). Evaluation of the effects of propylisopropylacetic acid (PIA) on neuronal growth cone morphology. Neuropharmacology 56, 831-837.
42. Silverstone, P. H., McGrath, B. M. and Kim, H. (2005). Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. Bipolar Disord. 7, 1-10. (Pubitemid 40227831)
43. Snaar-Jagalska, B. E. and Van Haastert, P. J. (1994). G-protein assays in Dictyostelium. Methods Enzymol. 237, 387-408.
44. Soll, D. R., Wessels, D., Voss, E. and Johnson, O. (2001). Computer-assisted systems for the analysis of amoeboid cell motility. Methods Mol. Biol. 161, 45-58.
45. Takeda, K., Sasaki, A. T., Ha, H., Seung, H. A. and Firtel, R. A. (2007). Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium. J. Biol. Chem. 282, 11874-11884. (Pubitemid 47100712)
46. 2+ signalling is not required for chemotaxis in Dictyostelium. EMBO J. 19, 4846-4854.
47. Vazquez, F., Matsuoka, S., Sellers, W. R., Yanagida, T., Ueda, M. and Devreotes, P. N. (2006). Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proc. Natl. Acad. Sci. USA 103, 3633-3638. (Pubitemid 43376607)
48. Veltman, D. M. and van Haastert, P. J. (2008). The role of cGMP and the rear of the cell in Dictyostelium chemotaxis and cell streaming. J. Cell Sci. 121, 120-127.
49. Williams, R. S., Eames, M., Ryves, W. J., Viggars, J. and Harwood, A. J. (1999). Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate. EMBO J. 18, 2734-2745. (Pubitemid 29233946)
50. Williams, R. S., Cheng, L., Mudge, A. W. and Harwood, A. J. (2002). A common mechanism of action for three mood-stabilizing drugs. Nature 417, 292-295. (Pubitemid 34534711)
51. Xu, X., Muller-Taubenberger, A., Adley, K. E., Pawolleck, N., Lee, V. W., Wiedemann, C., Sihra, T. S., Maniak, M., Jin, T. and Williams, R. S. (2007). Attenuation of phospholipid signalling provides a novel mechanism for the action of valproic acid. Eukaryot. Cell 6, 899-906. (Pubitemid 46983290)
52. Yates, J. R. (2006). Tuberous sclerosis. Eur. J. Hum. Genet. 14, 1065-1073.
53. Zhou, F. Q., Zhou, J., Dedhar, S., Wu, Y. H. and Snider, W. D. (2004). NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Neuron 42, 897-912. (Pubitemid 38798229)
54. Zigmond, S. H. (1977). Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J. Cell Biol. 75, 606-616.