Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart

Cardiovascular Research

Volumn 83, Issue 2, 2009, Pages 303-312

  Granata, Riccarda ^a   Trovato, Letizia ^a   Gallo, Maria Pia ^b   Destefanis, Silvia ^a   Settanni, Fabio ^a   Scarlatti, Francesca ^a   Brero, Alessia ^b   Ramella, Roberta ^b   Volante, Marco ^b   Isgaard, Jorgen ^c   Levi, Renzo ^b   Papotti, Mauro ^b   Alloatti, Giuseppe ^b   Ghigo, Ezio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cardiac myocyte cell death; Cardioprotection; GHRH; Ischaemia reperfusion injury

Indexed keywords

ADENYLATE CYCLASE; CASPASE 3; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; GROWTH HORMONE RELEASING FACTOR RECEPTOR; ISOPRENALINE; JV 136; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL POPULATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG ANTAGONISM; ENZYME ACTIVATION; FEMALE; HEART; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE; IN VITRO STUDY; IN VIVO STUDY; MYOCARDIAL ISCHEMIA REPERFUSION INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REPERFUSION INJURY; REPRESSOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STARVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; APOPTOSIS; CALCIUM; CASPASE 3; CELL LINE; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOPROTECTION; GROWTH HORMONE-RELEASING HORMONE; ISOPROTERENOL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PERFUSION; RATS; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE; RECOVERY OF FUNCTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 67650257490     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp090     Document Type: Article

References (39)

1. 1.tvan Empel VP, Bertrand AT, Hofstra L, Crijns HJ, Doevendans PA De Windt LJ. Myocyte apoptosis in heart failure. Cardiovasc Res 2005; 67:21-29.
2. Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 2002;415:206-212.
3. Singh K, Xiao L, Remondino A, Sawyer DB, Colucci WS. Adrenergic regulation of cardiac myocyte apoptosis. J Cell Physiol 2001;189:257-265.
4. Fujio Y, Nguyen T, Wencker D, Kitsis RN, Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 2000;101:660-667.
5. Sheng Z, Knowlton K, Chen J, Hoshijima M, Brown JH, Chien KR. Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy. J Biol Chem 1997;272:5783-5791.
6. Lin-Su K, Wajnrajch MP. Growth hormone releasing hormone (GHRH) and the GHRH receptor. Rev Endocr Metab Disord 2002;3:313-323.
7. Schally AV, Varga JL, Engel JB. Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab 2008;4:33-43.
8. Guillemin R, Brazeau P, Bohlen P, Esch F, Ling N, Wehrenberg WB. Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly. Science 1982;218:585-587.
9. Frohman LA, Kineman RD. Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis. Trends Endocrinol Metab 2002;13:299-303.
10. Mayo KE. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. Mol Endocrinol 1992;6:1734-1744.
11. Pombo CM, Zalvide J, Gaylinn BD, Dieguez C. Growth hormone-releasing hormone stimulates mitogen-activated protein kinase. Endocrinology 2000;141:2113-2119.
12. Christodoulou C, Schally AV, Chatzistamou I, Kondi-Pafiti A, Lamnissou K, Kouloheri S et al. Expression of growth hormone-releasing hormone (GHRH) and splice variant of GHRH receptors in normal mouse tissues. Regul Pept 2006;136:105-108.
13. Matsubara S, Sato M, Mizobuchi M, Niimi M, Takahara J. Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues. Endocrinology 1995;136:4147-4150.
14. Kiaris H, Schally AV, Kalofoutis A. Extrapituitary effects of the growth hormone-releasing hormone. Vitam Horm 2005;70:1-24.
15. Siriwardana G, Bradford A, Coy D, Zeitler P. Autocrine/paracrine regulation of breast cancer cell proliferation by growth hormone releasing hormone via Ras, Raf, and mitogen-activated protein kinase. Mol Endo-crinol 2006;20:2010-2019.
16. Fekete EM, Zorrilla EP. Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Front Neuroen-docrinol 2007;28:1-27.
17. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubini A et al. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J Cell Biol 2002;159:1029-1037.
18. Isgaard J, Barlind A, Johansson I. Cardiovascular effects of ghrelin and growth hormone secretagogues. Cardiovasc Hematol Disord Drug Targets 2008;8:133-137.
19. Cerra MC, Gallo MP, Angelone T, Quintieri AM, Pulera E, Filice E et al. The homologous rat chromogranin A1-64 (rCGA1-64) modulates myocardial and coronary function in rat heart to counteract adrenergic stimulation indirectly via endothelium-derived nitric oxide. FASEB J 2008;22: 3992-4004.
20. Penna C, Alloatti G, Cappello S, Gattullo D, Berta G, Mognetti B et al. Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. Am J Physiol Heart Circ Physiol 2005;288: H2512-H2520.
21. Granata R, Settanni F, Biancone L, Trovato L, Nano R, Bertuzzi F et al. Acylated and unacylated ghrelin promote proliferation and inhibit apop- tosis of pancreatic beta-cells and human islets: involvement of
22. 3,5-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling. Endocrinology 2007;148:512-529.
23. Granata R, Settanni F, Gallo D, Trovato L, Biancone L, Cantaluppi Vet al. Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function. Diabetes 2008;57:967-979.
24. Morisco C, Seta K, Hardt SE, Lee Y, Vatner SF, Sadoshima J. Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J Biol Chem 2001;276:28586-28597.
25. Tomita H, Nazmy M, Kajimoto K, Yehia G, Molina CA, Sadoshima J. Indu- cible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apop- tosis in response to beta-adrenergic receptor stimulation. Circ Res 2003; 93:12-22.
26. Obal F Jr, Fang J, Taishi P, Kacsoh B, Gardi J, Krueger JM. Deficiency of growth hormone-releasing hormone signaling is associated with sleep alterations in the dwarf rat. J Neurosci 2001;21:2912-2918.
27. Fan GC, Chu G, Mitton B, Song Q, Yuan Q, Kranias EG. Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis. Circ Res 2004;94:1474-1482.
28. Kovacs M, Schally AV, Lee EJ, Busto R, Armatis P, Groot K et al. Inhibitory effects of antagonistic analogs of GHRH on GH3 pituitary cells overex- pressing the human GHRH receptor. J Endocrinol 2002;175:425-434.
29. Matsui T, Rosenzweig A. Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 2005;38:63-71.
30. Dangel V, Giray J, Ratge D, Wisser H. Regulation of beta-adrenoceptor density and mRNA levels in the rat heart cell-line H9c2. Biochem J 1996;317(Pt 3):925-931.
31. Condorelli G, Roncarati R, Ross J Jr, Pisani A, Stassi G, Todaro M et al. Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function. Proc Natl Acad Sci USA 2001;98:9977-9982.
32. Henaff M, Hatem SN, Mercadier JJ. Low catecholamine concentrations protect adult rat ventricular myocytes against apoptosis through cAMP- dependent extracellular signal-regulated kinase activation. Mol Pharmacol 2000;58:1546-1553.
33. Takahashi T, Tang T, Lai NC, Roth DM, Rebolledo B, Saito M et al. Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction. Circulation 2006;114:388- 396.
34. Mehrhof FB, Muller FU, Bergmann MW, Li P, Wang Y, Schmitz W et al. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapopto- tic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation 2001; 104:2088-2094.
35. Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 1998;273:32377-32379.
36. Yehia G, Schlotter F, Razavi R, Alessandrini A, Molina CA. Mitogen- activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction. J Biol Chem 2001; 276:35272-35279.
37. Stork PJ, Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 2002;12:258-266.
38. Rekasi Z, Czompoly T, Schally AV, Boldizsar F, Varga JL, Zarandi M et al. Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway. Proc Natl Acad Sci USA 2005;102:3435-3440.
39. Hasegawa J, Saitoh M, Hirai S, Kinugawa T, Kotake H, Mashiba H. Positive inotropic effect of growth hormone releasing factor in the guinea-pig cardiac muscles in vitro. Horm Metab Res 1988;20:130-131.