The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor

Journal of Biological Chemistry

Volumn 284, Issue 24, 2009, Pages 16317-16324

  Mueller, Sandra ^a   Kieinau, Gunnar ^b   Szkudlinski, Mariusz W ^c   Jaeschke, Holger ^a   Krause, Gerd ^b   Paschke, Ralf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c Trophogen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PATTERN; CHARGED RESIDUES; GLYCOPROTEIN HORMONES; HORMONE RECEPTORS; POSITIVELY CHARGED; SIGNALING ACTIVITY;

AMINATION; AMINES; AMINO ACIDS; FETAL MONITORING; GLYCOPROTEINS; ORGANIC ACIDS;

SIGNALING;

ASPARTIC ACID; CYCLIC AMP; GLUTAMIC ACID; GLUTAMINE; LYSINE; THYROTROPIN; THYROTROPIN RECEPTOR; THYROTROPIN TR1401; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; COW; HINGE REGION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN VARIANT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; GLUTAMINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; THYROTROPIN;

BOVINAE;

EID: 67650242446     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.005710     Document Type: Article

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