The forkhead transcription factor Foxc2 stimulates osteoblast differentiation

Biochemical and Biophysical Research Communications

Volumn 386, Issue 3, 2009, Pages 532-536

  Kim, Se Hwa ^a   Cho, Kyoung Won ^b   Choi, Han Seok ^c   Park, Su Jin ^d   Rhee, Yumie ^c   Jung, Han Sung ^b   Lim, Sung Kil ^c,d  

^a Kwandong University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

^d Yonsei University   (South Korea)

Author keywords

catenin; Foxc2; Osteoblast; Osteoblast differentiation; TCF LEF; Wnt

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; MESSENGER RNA; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SIALOPROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXC2; WNT PROTEIN;

ANIMAL CELL; ARTICLE; CALVARIA; CELL DIFFERENTIATION; CONTROLLED STUDY; MESENCHYME CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE; FORKHEAD TRANSCRIPTION FACTORS; MESENCHYMAL STEM CELLS; MICE; ORGAN CULTURE TECHNIQUES; OSTEOBLASTS; RNA, SMALL INTERFERING; SKULL; WNT PROTEINS;

MUS;

EID: 67650229581     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.06.071     Document Type: Article

References (30)

1. Ducy P., Zhang R., Geoffroy V., Ridall A.L., and Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89 (1997) 747-754
2. Yoshida C.A., Yamamoto H., Fujita T., Furuichi T., Ito K., Inoue K., Yamana K., Zanma A., Takada K., Ito Y., and Komori T. Runx2 and Runx3 are essential for chondrocytes maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 18 (2004) 952-963
3. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., Shimizu Y., Bronson R.T., Gao Y.H., Inada M., Sato M., Okamoto R., Kitamura Y., Yoshiki S., and Kishimoto T. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89 (1997) 755-764
4. Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J.M., Behringer R.R., and de Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108 (2002) 17-29
5. Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., Wang H., Cundy T., Glorieux F.H., Lev D., Zacharin M., Oexle K., Marcelino J., Suwairi W., Heeger S., Sabatakos G., Apte S., Adkins W.N., Allgrove J., Arslan-Kirchner M., Batch J.A., Beighton P., Black G.C., Boles R.G., Boon L.M., Borrone C., Brunner H.G., Carle G.F., Dallapiccola B., De Paepe A., Floege B., Halfhide M.L., Hall B., Hennekam R.C., Hirose T., Jans A., Jüppner H., Kim C.A., Keppler-Noreuil K., Kohlschuetter A., LaCombe D., Lambert M., Lemyre E., Letteboer T., Peltonen L., Ramesar R.S., Romanengo M., Somer H., Steichen-Gersdorf E., Steinmann B., Sullivan B., Superti-Furga A., Swoboda W., van den Boogaard M.J., Van Hul W., Vikkula M., Votruba M., Zabel B., Garcia T., Baron R., Olsen B.R., and Warman M.L. Osteoporosis - Pseudoglioma Syndrome Collaborative Group LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 (2001) 513-523
6. Bodine P.V., Zhao W., Kharode Y.P., Bex F.J., Lambert A.J., Goad M.B., Gaur T., Stein G.S., Lian J.B., and Komm B.S. The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice. Mol. Endocrinol. 18 (2004) 1222-1237
7. Behrens J., von Kries J.P., Kühl M., Bruhn L., Wedlich D., Grosschedl R., and Birchmeier W. Functional interaction of β-catenin with the transcriptional factor LEF-1. Nature 382 (1996) 638-642
8. Krishnan V., Bryant H.U., and Macdougald O.A. Regulation of bone mass by Wnt signaling. J. Clin. Invest. 116 (2006) 1202-1209
9. Kato M., Patel M.S., Levasseur R., Lobov I., Chang B.H., Glass II D.A., Hartmann C., Li L., Hwang T.H., Brayton C.F., Lang R.A., Karsenty G., and Chan L. Cbfa1-indepdendent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptors. J. Cell. Biol. 157 (2002) 303-314
10. Johnson M.L., Harnish K., Nusse R., and Van Hul W. LRP5 and Wnt signaling: a union made for bone. J. Bone Miner. Res. 19 (2004) 1749-1757
11. Carlsson P., and Mahlapuu M. Forkhead transcription factors; key players in development and metabolism. Dev. Biol. 250 (2002) 1-23
12. Miura N., Wnanka A., Tohyama M., and Tanaka K. MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett. 326 (1993) 171-176
13. Kaestner K.H., Bleckmann S.C., Monaghan A.P., Schlöndorff J., Mincheva A., Lichter P., and Schütz G. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development 122 (1996) 1751-1758
14. Iida K., Koseki H., Kakinuma H., Kato N., Mizutani-Koseki Y., Ohuchi H., Yoshioka H., Noji S., Kawamura K., Kataoka Y., Ueno F., Taniguchi M., Yoshida N., Sugiyama T., and Miura N. Essential roles of winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124 (1999) 4627-4638
15. Winner G.E., Hargett L., and Hogan B.L.M. The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 11 (1997) 926-940
16. Furumoto T.A., Miura N., Akasaka T., Mizutani-Koseki Y., Sudo H., Fukuda K., Maekawa M., Yuasa S., Fu Y., Moriya H., Taniguchi M., Imai K., Dahl E., Balling R., Pavlova M., Gossler A., and Koseki H. Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev. Biol. 210 (1999) 15-29
17. Bergman R.J., Gazit D., Kahn A.J., Gruber H., McDougall S., and Hahn T.J. Age-related changes in osteogenic stem cells in mice. J. Bone Miner. Res. 11 (1996) 568-577
18. Parhami F., Jackson S.M., Tintut Y., Le V., Balucan J.P., Territo M., and Demer L.L. Athergenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J. Bone Miner. Res. 14 (1999) 2067-2078
19. Cederberg A., Gronning L.M., Ahren B., Tasken K., Carlsson P., and Enerback S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106 (2001) 563-573
20. Davis K.E., Moldes M., and Farmer S.R. The forkhead transcription factor Foxc2 inhibits white adipocyte differentiation. J. Biol. Chem. 279 (2004) 42453-42461
21. Iida K., Koseki H., Kakinuma H., Kato N., Mizutani-Koseki Y., Ohuchi H., Yoshioka H., Noji S., Kawamura K., Kataoka Y., Ueno F., Taniguchi M., Yoshida N., Sugiyama T., and Miura N. Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. Development 124 (1997) 4627-4638
22. Park M.H., Shin H.I., Choi J.Y., Nam S.H., Kim Y.J., Kim H.J., and Ryoo H.M. Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis. J. Bone Miner. Res. 16 (2001) 885-892
23. Yang X., Matsuura H., Fu Y., Sugiyama T., and Miura N. MFH-1 is required for bone morphogenetic protein-2 induced osteoblastic differentiation of C2C12 myoblasts. FEBS Lett. 470 (2000) 29-34
24. Bain G., Muller T., Wang X., and Papkoff J. Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem. Biophys. Res. Commun. 301 (2003) 84-91
25. Hill T.P., Spater D., Taketo M.M., Birchmeier W., and Hartmann C. Canonical Wnt/β-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev. Cell 8 (2005) 727-738
26. Rubinfeld B., Albert I., Porfiri E., Fiol C., Munemitsu S., and Polakis P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 272 (1996) 1023-1026
27. Fang X., Yu S.X., Lu Y., Bast R.C., Woodgett J.R., and Mills B.G. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. USA 97 (2000) 11960-11965
28. Li M., Wang X., Meintzer M.K., Laessig T., Birnbaum M.J., and Heidenreich K.A. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β. Mol. Cell. Biol. 20 (2000) 9356-9363
29. Chen A.E., Ginty D.D., and Fan C.M. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature 433 (2005) 208-209
30. Hino S., Tanji C., Nakayama K.I., and Kikuchi A. Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination. Mol. Cell. Biol. 25 (2005) 9063-9072