Ruthenium complexes endowed with potent anti-Trypanosoma cruzi activity: Synthesis, biological characterization and structure-activity relationships

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5038-5043

  Donnici, Claudio Luis ^a   Araújo, Maria Helena ^a   Oliveira, Henrique S ^a   Moreira, Diogo Rodrigo Magalhães ^b   Pereira, Valéria R Alves ^c   de Assis Souza, Marina ^c   de Castro, Maria Carolina Accioly Brelaz ^c   Leite, Ana Cristina Lima ^b  

^a LASELORG   (Brazil)

^b LABSINFA Laboratório de Planejamento   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

DNA interaction; Hydrazone; Metal complexes; Ruthenium; Thiazole; Trypanosoma cruzi

Indexed keywords

DICHLORO [2 (4 BROMOPHENYLTHIOETHYLIDENE)HYDRAZONE 1,3 THIAZOL 4(5H) ONE]CYCLOOCTADIENE RUTHENIUM; HYDRAZONE DERIVATIVE; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMASTIGOTE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DNA; HYDRAZONES; MICE; MICE, INBRED BALB C; PLASMIDS; RUTHENIUM COMPOUNDS; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

MAMMALIA; TRYPANOSOMA CRUZI;

EID: 67650224807     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.071     Document Type: Article

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