4-Nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity

European Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2008, Pages 939-948

  Pérez Rebolledo, Anayive ^a   Teixeira, Letícia R ^b   Batista, Alzir A ^c   Mangrich, Antonio S ^d   Aguirre, Gabriela ^e   Cerecetto, Hugo ^e   González, Mercedes ^e   Hernández, Paola ^e   Ferreira, Ana M ^e   Speziali, Nivaldo L ^a   Beraldo, Heloisa ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^d FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^e UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

4 Nitroacetophenone thiosemicarbazones; Anti trypanosomal activity; Copper(II) complexes

Indexed keywords

4 NITROACETOPHENONE; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; COPPER COMPLEX; COPPER N 4 METHYL 4 NITROACETOPHENONE THIOSEMICARBAZONE; COPPER N 4 PIPERIDYL 4 NITROACETOPHENONE THIOSEMICARBAZONE; COPPER N 4,N 4 DIMETHYL 4 NITROACETOPHENONE THIOSEMICARBAZONE; N 4 METHYL 4 NITROACETOPHENONE THIOSEMICARBAZONE; N 4 PIPERIDYL 4 NITROACETOPHENONE THIOSEMICARBAZONE; N 4,N 4 DIMETHYL 4 NITROACETOPHENONE THIOSEMICARBAZONE; NIFURTIMOX; THIOSEMICARBAZONE DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIC POTENTIOMETRY; DRUG CYTOTOXICITY; DRUG EFFICACY; ELECTRON SPIN RESONANCE; EPIMASTIGOTE; IN VITRO STUDY; INFRARED SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; TRYPANOSOMA CRUZI;

ACETOPHENONES; ANIMALS; CHELATING AGENTS; COPPER; CRYSTALLOGRAPHY, X-RAY; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; MACROPHAGES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; THIOSEMICARBAZONES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 42949178088     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.020     Document Type: Article

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