Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and β-catenin/TCF signaling

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Bheda, Anjali ^a   Yue, Wei ^a   Gullapalli, Anuradha ^a   Whitehurst, Chris ^a   Liu, Renshui ^a   Pagano, Joseph S ^a,b   Shackelford, Julia ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MESSENGER RNA; T CELL FACTOR PROTEIN; UBIQUITIN THIOLESTERASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL TRANSFORMATION; CHROMATIN IMMUNOPRECIPITATION; COMPLEX FORMATION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MUTAGENESIS; NEOPLASM; NEUROLOGIC DISEASE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL LINE; CELL STRAIN 3T3; CHEMISTRY; GENE EXPRESSION REGULATION; MOUSE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ANIMALS; BETA CATENIN; BINDING SITES; CELL LINE, TRANSFORMED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MUTAGENESIS; MUTAGENESIS, SITE-DIRECTED; NIH 3T3 CELLS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; UBIQUITIN THIOLESTERASE; UP-REGULATION;

EID: 67650146161     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005955     Document Type: Article

References (39)

1. Finley D, Ciechanover A, Varshavsky A (2004) Ubiquitin as a central cellular regulator. Cell 116: S29-32, 22 p following S32.
2. Barker N, Morin PJ, Clevers H (2000) The Yin-Yang of TCF/beta-catenin signaling. Adv Cancer Res 77: 1-24.
3. Brembeck FH, Rosario M, Birchmeier W (2006) Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 16: 51-59.
4. Barker N, Clevers H (2000) Catenins, Wnt signaling and cancer. Bioessays 22: 961-965.
5. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
6. Kikuchi A, Kishida S, Yamamoto H (2006) Regulation of Wnt signaling by protein-protein interaction and post-translational modifications. Exp Mol Med 38: 1-10.
7. Shackelford J, Maier C, Pagano JS (2003) Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes. Proc Natl Acad Sci U S A 100: 15572-15576.
8. Taya S, Yamamoto T, Kanai-Azuma M, Wood SA, Kaibuchi K (1999) The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin. Genes Cells 4: 757-767.
9. Larsen CN, Price JS, Wilkinson KD (1996) Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues. Biochemistry 35: 6735-6744.
10. Betarbet R, Sherer TB, Greenamyre JT (2005) Ubiquitin-proteasome system and Parkinson's diseases. Exp Neurol 191 Suppl 1: S17-27.
11. Setsuie R, Wada K (2007) The functions of UCH-L1 and its relation to neurodegenerative diseases. Neurochem Int 51: 105-111.
12. Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr (2002) The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Cell 111: 209-218.
13. Osaka H, Wang YL, Takada K, Takizawa S, Setsuie R, et al. (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet 12: 1945-1958.
14. Hibi K, Westra WH, Borges M, Goodman S, Sidransky D, et al. (1999) PGP9.5 as a candidate tumor marker for non-small-cell lung cancer. Am J Pathol 155: 711-715.
15. Otsuki T, Yata K, Takata-Tomokuni A, Hyodoh F, Miura Y, et al. (2004) Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells. Br J Haematol 127: 292-298.
16. Loeffler-Ragg J, Skvortsov S, Sarg B, Skvortsova I, Witsch-Baumgartner M, et al. (2005) Gefitinib-responsive EGFR-positive colorectal cancers have different proteome profiles from non-responsive cell lines. Eur J Cancer 41: 2338-2346.
17. Ovaa H, Kessler BM, Rolen U, Galardy PJ, Ploegh HL, et al. (2004) Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A 101: 2253-2258.
18. Yang YC, Li X, Chen W (2006) Characterization of genes associated with different phenotypes of human bladder cancer cells. Acta Biochim Biophys Sin (Shanghai) 38: 602-610.
19. Miyoshi Y, Nakayama S, Torikoshi Y, Tanaka S, Ishihara H, et al. (2006) High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer. Cancer Sci 97: 523-529.
20. Kim HJ, Kim YM, Lim S, Nam YK, Jeong J, et al. (2008) Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis. Oncogene.
21. Rolen U, Freda E, Xie J, Pfirmann T, Frisan T, et al. (2008) The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation. J Cell Mol Med.
22. Trowern AR, Mann DA (1999) A bi-functional activator/repressor element required for transcriptional activity of the human UCH-L1 gene assembles a neuron-specific protein: single-strand DNA complex. Neurosci Lett 272: 25-28.
23. Mann DA, Trowern AR, Lavender FL, Whittaker PA, Thompson RJ (1996) Identification of evolutionary conserved regulatory sequences in the 5′ untranscribed region of the neural-specific ubiquitin C-terminal hydrolase (PGP9.5) gene. J Neurochem 66: 35-46.
24. Day IN, Hinks LJ, Thompson RJ (1990) The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase. Biochem J 268: 521-524.
25. Joaquin M, Watson RJ (2003) Cell cycle regulation by the B-Myb transcription factor. Cell Mol Life Sci 60: 2389-2401.
26. Long EM, Long MA, Tsirigotis M, Gray DA (2003) Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor. Lung Cancer 42: 9-21.
27. Shackelford J, Pagano JS (2005) Targeting of host-cell ubiquitin pathways by viruses. Essays Biochem 41: 139-156.
28. Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, et al. (2002) Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). Oncogene 21: 3003-3010.
29. van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991) Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. Embo J 10: 123-132.
30. Jope RS, Bijur GN (2002) Mood stabilizers, glycogen synthase kinase-3beta and cell survival. Mol Psychiatry 7 Suppl 1: S35-45.
31. Riese J, Yu X, Munnerlyn A, Eresh S, Hsu SC, et al. (1997) LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell 88: 777-787.
32. Roose J, Clevers H (1999) TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta 1424: M23-37.
33. Forde JE, Dale TC (2007) Glycogen synthase kinase 3: a key regulator of cellular fate. Cell Mol Life Sci 64: 1930-1944.
34. Mandelker DL, Yamashita K, Tokumaru Y, Mimori K, Howard DL, et al. (2005) PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. Cancer Res 65: 4963-4968.
35. Okochi-Takada E, Nakazawa K, Wakabayashi M, Mori A, Ichimura S, et al. (2006) Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer.
36. Fukutomi S, Seki N, Koda K, Miyazaki M (2007) Identification of methylation-silenced genes in colorectal cancer cell lines: Genomic screening using oligonucleotide arrays. Scand J Gastroenterol 42: 1486-1494.
37. Howell VM, Gill A, Clarkson A, Nelson AE, Dunne R, et al. (2008) Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma. J Clin Endocrinol Metab.
38. Bheda A, Shackelford J, Pagano J Expression profiling of genes regulated by Ubiquitin C-terminal Hydrolase L1, submitted.
39. Kozbor D, Lagarde AE, Roder JC (1982) Human hybridomas constructed with antigen-specific Epstein-Barr virus-transformed cell lines. Proc Natl Acad Sci U S A 79: 6651-6655.