Substrate binding and catalysis by ubiquitin C-terminal hydrolases: Identification of two active site residues

Biochemistry

Volumn 35, Issue 21, 1996, Pages 6735-6744

  Larsen, Christopher N ^a   Price, Joanne S ^a,b   Wilkinson, Keith D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; UBIQUITIN;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; DISULFIDE BOND; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SITE DIRECTED MUTAGENESIS; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; CYSTEINE; DROSOPHILA; ESCHERICHIA COLI; HUMANS; ISOENZYMES; KINETICS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; THERMODYNAMICS; THIOLESTER HYDROLASES; UBIQUITIN THIOLESTERASE;

EUKARYOTA; MAMMALIA;

EID: 0029999683     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960099f     Document Type: Article

References (50)

1. Alexander, P., Fahnestock, S., Lee, T., Orban, J., & Bryan, P. (1992) Biochemistry 31, 3597.
2. Alix, J. P., Pedanou, G., & Berjot, M. (1988) J. Mol. Struct. 174, 159.
3. Baker, R. T., Tobias, J. W., & Varshavsky, A. (1992) J. Biol. Chem. 267, 23364.
4. Beltramini, M., Bubacco, L., Salvato, B., Casella, L., Gullotti, M., & Garofani, S. (1992) Biochim. Biophys. Acta 1120.
5. Blazy, B., Baudras, A., & Maurizot, J. C. (1992) Biochim. Biophys. Acta 1120, 223.
6. Burch, T., & Haas, A. (1994) Biochemistry 33, 300.
7. Day, I. N. M., Hinks, L. J., & Thompson, R. J. (1990) Biochem. J. 268, 521.
8. Deveraux, Q., Ustrell, V., Pickart, C., & Rechsteiner, M. (1994) J. Biol. Chem. 269, 7059.
9. Duerksen-Hughes, P., Williamson, M., & Wilkinson, K. D. (1989) Biochemistry 28, 8530.
10. Eytan, E., Ganoth, D., Armon, T., & Hershko, A. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7751.
11. Finley, D., Ozkaynak, E., & Varshavsky, A. (1987) Cell 48, 1035.
12. Finley, D., Bartel, B., & Varshavsky, A. (1989) Nature 338, 394.
13. Fox, T., Mason, P., Storer, A., & Mort, J. S. (1995) Protein Eng. 8, 53.
14. Greenfield, N., & Fasman, G. (1969) Biochemistry 8, 4108.
15. Grobler, J. A., Wang, M., Pike, A. C. W., & Brew, K. (1994) J. Biol. Chem. 269, 5106.
16. Higgins, D. G., & Sharp, P. M. (1989) Comput. Appl. Biosci. 5, 151.
17. Hough, R., Pratt, G., & Rechsteiner, M. (1987) J. Biol. Chem. 262, 8303.
18. Hummel, J. P., & Dreyer, W. J. (1962) Biochim. Biophys. Acta 63, 530.
19. Johnson, W. C. (1988) Ann. Rev. Biophys. Chem. 7, 145.
20. Kajimoto, Y., Hashimoto, T., Shirai, Y., Nishino, N., Kuno, T., & Tanaka, C. (1992) J. Biochem. 112, 28.
21. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 488.
22. Lippert, J. L., Tyminski, D., & Desmeules, P. J. (1976) J. Am. Chem. Soc. 98, 7075.
23. Liu, C. C., Miller, H. I., Kohr, W. J., & Silber, J. I. (1989) J. Biol. Chem. 264, 20331.
24. Lowe, J., McDermott, H., Landon, M., Mayer, R. J., & Wilkinson, K. D. (1990) J. Pathol. 161, 153.
25. Matsui, S., Sandberg, A. A., Negoro, S., Seon, B. K., & Goldstein, G. (1982) Proc. Natl. Acad. Sci. U.S.A. 79, 1535.
26. Mayer, A., & Wilkinson, K. D. (1989) Biochemistry 28, 166.
27. Orsi, B. A., & Tipton, K. F. (1979) Methods Enzymol. 63, 159.
28. Ozkaynak, E., Finley, D., Solomon, M. J., & Varshavsky, A. (1987) EMBO J. 6, 1429.
29. Papa, F. R., & Hochstrasser, M. (1993) Nature 366, 313.
30. Pickart, C. M., & Rose, I. A. (1985) J. Biol. Chem. 260, 7903.
31. Pickart, C. M., & Rose, I. A. (1986) J. Biol. Chem. 261, 10210.
32. Privalov, P. L. (1979) Adv. Protein Chem. 33, 205.
33. Privalov, P. L., & Khechinashvili, N. N. (1974) J. Mol. Biol. 86, 665.
34. Privalov, P. L., & Gill, S. J. (1988) Adv. Protein Chem. 39, 191.
35. Privalov, P. L., & Makhatadze, G. I. (1990) J. Mol. Biol. 213, 385.
36. Rost, B., & Sander, C. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7558.
37. Sanger, F., Nicklen, S., & Coulson, A. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463.
38. Sambrook, J., Fritsch, E. F., & Maniatis, T. (1989) in Molecular Cloning: A Laboratory Manual, Section 1.72-73, Cold Spring Harbor Press, Cold Spring Harbor, NY.
39. Schechter, I., & Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157.
40. Tobias, J. W., & Varshavsky, A. (1991) J. Biol. Chem. 266, 12021.
41. Vaaler, G. L., & Snell, E. E. (1989) Biochemistry 28, 7306.
42. Vuillemier, S., Sancho, J., Loewenthal, R., & Fersht, A. (1993) Biochemistry 32, 1030.
43. Walker, N. P. C., Talanian, R. V., Brady, K. D., Dang, L. C., Bump, N. J., Ferenz, C. R., Franklin, S., Ghayur, T., Hackett, M. C., Hammill, L. D., Herzog, L., Hugunin, M., Houy, W., Mankovich, J. A., McGuinness, L., Orlewicz, E., Paskind, M., Pratt, C. A., Reis, P., Summani, A., Terranova, M., Welch, J. P., Xiong, L., Moller, A., Tracey, D. E., Kamen, R., & Wong, W. W. (1994) Cell 78, 343.
44. Wilkinson, K. D. (1995) Annu. Rev. Nutr. 15, 161.
45. Wilkinson, K. D., Cox, M. J., Mayer, A. N., & Frey, T. (1986) Biochemistry 25, 6644.
46. Wilkinson, K. D., Lee, K., Deshpande, S., Duerksen-Hughes, P., Boss, J., & Pohl, J. (1989) Science 246, 670.
47. Wilkinson, K. D., Larsen, C. N., & Deshpande, S. (1992) Biochem. Soc. Trans. 20, 631.
48. Wilkinson, K. D., Tashayev, V. L., O'Connor, L. B., Larsen, C. N., Kasperek, E., & Pickart, C. M. (1995) Biochemistry 34, 14535.
49. Wostmann, C., Tannich, E., & Bakker-Grunwald, T. (1992) FEBS Lett. 308, 54.
50. Zhang, N., Wilkinson, K. D., & Bownes, M. (1993) Dev. Biol. 157, 214.