Hindlimb unweighting induces changes in the p38MAPK contractile pathway of the rat abdominal aorta

Journal of Applied Physiology

Volumn 107, Issue 1, 2009, Pages 121-127

  Summers, Scott Matthew ^a   Hayashi, Yuichiro ^a   Nguyen, Steven Vu ^a   Nguyen, Thu Minh ^a   Purdy, Ralph Earl ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Extracellular signal regulated kinase; Heat shock protein 27; Microgravity; Orthostatic intolerance; Phorbol ester

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALDESMON; ENZYME INHIBITOR; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHENYLEPHRINE; PHORBOL DIBUTYRATE; U 0123; UNCLASSIFIED DRUG;

ABDOMINAL AORTA; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HINDLIMB; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SENSITIVITY ANALYSIS; THIN FILAMENT; WESTERN BLOTTING;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; AORTA, ABDOMINAL; BUTADIENES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HINDLIMB SUSPENSION; HSP27 HEAT-SHOCK PROTEINS; IMIDAZOLES; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLEPHRINE; PHORBOL 12,13-DIBUTYRATE; PYRIDINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 67650082470     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00210.2009     Document Type: Article

References (36)

1. Cao W, Sohn UD, Bitar KN, Behar J, Biancani P, Harnett KM. MAPK mediates PKC-dependent contraction of cat esophageal and lower esophageal sphincter circular smooth muscle. Am J Physiol Gastrointest Liver Physiol 285: G86-G95, 2003.
2. Catterson AD, McCutcheon EP, Minners HA, Pollard RA. Aeromedical observations. In: Mercury Project Summary Including Results of the Fourth Manned Orbital Flight May 15 and 16, 1963. NASA: Washington, DC, 1963, p. 299-326 (SP-45).
3. Chen KD, Li YS, Kim M, Li S, Yuan S, Chien S, Shyy JY. Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem 274: 18393-18400, 1999.
4. Chew HG Jr, Segal SS. Arterial morphology and blood volumes of rats following 10-14 weeks of tail suspension. Med Sci Sports Exerc 29: 1304-1310, 1997.
5. Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, Delp MD. Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling. J Appl Physiol 89: 1046-1054, 2000.
6. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR, Lee JC. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364: 229-33, 1995.
7. Delp MD. Myogenic and vasoconstrictor responsiveness of skeletal muscle arterioles is diminished by hindlimb unloading. J Appl Physiol 86: 1178-1184, 1999.
8. Delp MD, Colleran PN, Wilkerson MK, McCurdy MR, Muller-Delp J. Structural and functional remodeling of skeletal muscle microvasculature is induced by simulated microgravity. Am J Physiol Heart Circ Physiol 278: H1866-H1873, 2000.
9. Delp MD, Holder-Binkley T, Laughlin MH, Hasser EM. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J Appl Physiol 75: 2620-2628, 1993.
10. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM. Identification of a novel inhibitor of mitogen-activated protein kinase. J Biol Chem 273: 18623-32, 1998.
11. Hague C, Gonzalez-Cabrera PJ, Jeffries WB, Abel PW. Relationship between alpha 1-adrenergic receptor-induced contraction and extracellular signal-regulated kinase activation in the bovine inferior alveolar artery. J Pharmacol Exp Ther 303: 403-411, 2002.
12. Hargens AR, Watenpaugh DE. Cardiovascular adaptation to spaceflight. Med Sci Sports Exerc 28: 977-82, 1996.
13. Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, Gerthoffer WT. p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol Cell Physiol 275: C527-C534, 1998.
14. Kalyankrishna S, Malik KU. Norepinephrine-induced stimulation of p38 mitogen-activated protein kinase is mediated by arachidonic acid metabolites generated by activation of cytosolic phospholipase A2 in vascular smooth muscle cells. J Pharmacol Exp Ther 304: 761-772, 2003.
15. Kulikova N, Pronina OE, Dabrowska R, Borovikov YS. Caldesmon inhibits the actin-myosin interaction by changing its spatial orientation and mobility during the ATPase activity cycle. Biochem Biophys Res Commun 357: 461-466, 2007.
16. Lavoie JN, Hickey E, Weber LA, Landry J. Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J Biol Chem 268: 24210-24214, 1993.
17. Liao DF, Monia B, Dean N, Berk BC. Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem 272: 6146-6150, 1997.
18. Ma J, Zhang LF, Yu ZB. Effects of 14-day tail suspension on vasoreactivity of arteries from different parts of the body in rats. J Gravit Physiol 3: 9-10, 1996.
19. Mao QW, Zhang LF, Zhang LN, Ma J. Ultrastructural changes of arterial wall from different body parts of rats during simulated weightlessness. Space Med Med Eng (Beijing) 12: 249-253, 1999.
20. Meck JV, Reyes CJ, Perez SA, Goldberger AL, Ziegler MG. Marked exacerbation of orthostatic intolerance after long- vs. short-duration space-flight in veteran astronauts. Psychosom Med 63: 865-873, 2001.
21. Nakanishi H, Brewer KA, Exton JH. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 268: 13-16, 1993.
22. Nyhan D, Kim S, Dunbar S, Li D, Shoukas A, Berkowitz DE. Impaired pulmonary artery contractile responses in a rat model of microgravity: role of nitric oxide. J Appl Physiol 92: 33-40, 2002.
23. Papadopoulos A, Delp MD. Effects of hindlimb unweighting on the mechanical and structure properties of the rat abdominal aorta. J Appl Physiol 94: 439-445, 2003.
24. Pichon S, Bryckaert M, Berrou E. Control of actin dynamics by p38 MAP kinase-Hsp27 distribution in the lamellipodium of smooth muscle cells. J Cell Sci 117: 2569-2577, 2004.
25. Purdy RE, Duckles SP, Krause DN, Rubera KM, Sara D. Effect of simulated microgravity on vascular contractility. J Appl Physiol 85: 1307-1315, 1998.
26. Rucci N, DiGiacinto C, Orrù L, Millimaggi D, Baron R, Teti A. A novel protein kinase C alpha-dependent signal to ERK1/2 activated by αVβ3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J Cell Sci 118:3263-3275, 2005.
27. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol 70: 1537-1547, 2005.
28. Sangha DS, Vaziri ND, Ding Y, Purdy RE. Vascular hyporesponsiveness in simulated microgravity: role of nitric oxide-dependent mechanisms. J Appl Physiol 88: 507-17, 2000.
29. Summers SM, Nguyen SV, Purdy RE. Hindlimb unweighting induces changes in the RhoA-Rho kinase pathway of the rat abdominal aorta. Vascul Pharmacol 48: 208-214, 2008.
30. Summers SM, Ulloa AS, Purdy RE. Endothelial role in the thoracic aorta response to hindlimb unloading in rats. Aviat Space Environ Med 78: 1103-1107, 2007.
31. Tuday EC, Meck JV, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance. J Appl Physiol 102: 853-858, 2007.
32. Wilkerson MK, Lesniewski LA, Golding EM, Bryan RM Jr, Amin A, Wilson E, Delp MD. Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism. Am J Physiol Heart Circ Physiol 288: H1652-H1661, 2005.
33. Xiao D, Zhang L. ERK MAP kinases regulate smooth muscle contraction in ovine uterine artery: effect of pregnancy. Am J Physiol Heart Circ Physiol 282: H292-H300, 2002.
34. Zeidan A, Javadov S, Chakrabarti S, Karmazyn M. Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ ROCK-dependent p38 MAPK translocation to nuclei. Cardiovasc Res 77: 64-72, 2008.
35. Zhang LF. Vascular adaptation to microgravity: what have we learned? J Appl Physiol 91: 2415-2430, 2001.
36. Zhang LN, Zhang LF, Ma J. Simulated microgravity enhances vasoconstrictor responsiveness of rat basilar artery. J Appl Physiol 90: 2296-2305, 2001.