High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: Insight into inhibitor binding

Biochemistry

Volumn 48, Issue 26, 2009, Pages 6166-6174

  Lingott, Torsten ^a   Schleberger, Christian ^a   Gutiérrez, José María ^b   Merfort, Irmgard ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMALYSINS; BOUND INHIBITORS; CATALYTIC DOMAINS; CONVERTING ENZYME; DERMONECROSIS; HIGH RESOLUTION CRYSTAL STRUCTURE; HIGH-RESOLUTION STRUCTURES; INHIBITOR DESIGN; LOOP REGIONS; MATRIX METALLOPROTEINASES; METALLOPROTEINASE; METALLOPROTEINASES; PATHOLOGICAL EFFECTS; PEPTIDOMIMETIC; PH VALUE; SNAKE VENOMS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATIONSHIPS; TUMOR NECROSIS FACTORS; ZINC BINDING;

BLOOD VESSELS; STRUCTURAL DESIGN; ZINC;

CRYSTAL STRUCTURE;

METALLOPROTEINASE; METALLOPROTEINASE BAP1; METALLOPROTEINASE INHIBITOR; PEPTIDOMIMETIC AGENT; SNAKE VENOM; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME STRUCTURE; PH; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOCATALYSIS; BOTHROPS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; KINETICS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; VIPER VENOMS; WATER; ZINC;

EID: 67650081565     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9002315     Document Type: Article

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