Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5229-5237

  Kontijevskis, Aleksejs ^a   Petrovska, Ramona ^a   Yahorava, Sviatlana ^a   Komorowski, Jan ^a   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

HIV 1 protease inhibitors; Molecular recognition; Proteochemometrics; Resistance; Retroviral proteases

Indexed keywords

AMINO ACID; HEXAPEPTIDE; PEPTIDE LIBRARY; PROTEINASE; PROTEINASE INHIBITOR; VIRUS ENZYME;

ARTICLE; CHEMOMETRICS; COMPUTER MODEL; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PROTEOCHEMOMETRICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL MODEL; VALIDATION PROCESS;

AMINO ACID SEQUENCE; COMPUTATIONAL BIOLOGY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; HIV-1; MODELS, BIOLOGICAL; MUTATION; PEPTIDE HYDROLASES; PEPTIDES; PROTEASE INHIBITORS; PROTEIN BINDING; RETROVIRIDAE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 67650075222     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.045     Document Type: Article

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