An N-aroyltransferase of the bahd superfamily has broad aroyl CoA specificity in vitro with analogues of N-dearoylpaclitaxel

Journal of the American Chemical Society

Volumn 131, Issue 16, 2009, Pages 5994-6002

  Nevarez, Danielle M ^a   Mengistu, Yemane A ^a   Nawarathne, Irosha N ^a   Walker, Kevin D ^a,b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL GROUP; ACYL TRANSFER; AMINO FUNCTIONAL GROUP; AMINO GROUP; BENZOYL GROUP; BIOSYNTHETIC PATHWAY; CATALYTIC EFFICIENCIES; COA THIOESTER; COMMERCIAL SOURCES; DITERPENE COMPOUNDS; DOCETAXEL; IN-VITRO; PACLITAXEL; PURIFIED ENZYME; RELATIVE VELOCITY; SIDE CHAINS; SUBSTRATE SPECIFICITY; TAXANES; TAXUS PLANT;

AMINATION; AMINES; AMINO ACIDS; DRUG PRODUCTS; ENZYMES; ESCHERICHIA COLI; FUNCTIONAL GROUPS; HYDROGELS; OLEFINS;

SUBSTRATES;

CARBONYL DERIVATIVE; COENZYME A; N DEBENZOYL 2' DEOXYPACLITAXEL N BENZOYLTRANSFERASE; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG; ACYL COENZYME A; ACYLTRANSFERASE; BRIDGED COMPOUND; PACLITAXEL; TAXANE; TAXOID; VEGETABLE PROTEIN;

ARTICLE; CATALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; IN VITRO STUDY; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; SYNTHESIS; TAXUS;

ACYL COENZYME A; ACYLTRANSFERASES; BIOCATALYSIS; BRIDGED COMPOUNDS; ESCHERICHIA COLI; KINETICS; PACLITAXEL; PLANT PROTEINS; SUBSTRATE SPECIFICITY; TAXOIDS; TAXUS;

EID: 69949143835     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja900545m     Document Type: Article

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