High frequency of low-level microsatellite instability in early colorectal cancer

Cancer Research

Volumn 61, Issue 21, 2001, Pages 7743-7746

  Kambara, Takeshi ^a   Matsubara, Nagahide ^a,c   Nakagawa, Hitoshi ^a   Nagasaka, Takeshi ^a   Isozaki, Hiroshi ^a   Tanaka, Noriaki ^a   Notohara, Kenji ^b   Yoshino, Tadashi ^b   Shimizu, Kenji ^c   Sharp, Gerald B ^d,e   Jass, Jeremy ^f  

^a Okayama University   (Japan)

^b Departments of Pathology   (Japan)

^c Departments of Molecular Genetics   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^f UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER INVASION; CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; HETEROZYGOSITY LOSS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MOLECULAR BIOLOGY; PHENOTYPE; PRIORITY JOURNAL;

AGED; CHROMOSOME ABERRATIONS; COLORECTAL NEOPLASMS; FEMALE; GENES, RAS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED;

EID: 0035503498     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Colorectal cancer: Classification and aspects of the proliferation kinetics
2. Colonoscopic detection of early colorectal cancers. Impact of a surgical endoscopy service
3. Early colorectal carcinoma with special reference to its development de novo
4. Endoscopic diagnosis and treatment of early colorectal cancer
5. A genetic model for colorectal tumorigenesis
6. Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression
7. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
8. Microsatellite instability in colorectal cancer: Different mutator phenotypes and the principal involvement of hMLHI
9. The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
10. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
11. Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
12. Lessons from hereditary colorectal cancer
13. Incidence and functional consequences of hMLH-promoter hypermethylation in colorectal carcinoma
14. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer-N
15. HMSH6 alterations in patients with microsatellite instability-low colorectal cancer
16. 6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
17. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: Evidence for a broad range tumor suppressor gene
18. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers
19. DNA microsatellite instability and mismatch repair protein in adenomas presenting in hereditary non-polyposis colorectal cancer
20. Rapid and sensitive nonradioactive detection of mutant K-ras genes via "enriched" PCR amplification
21. Prognostic value of chromosome 1p allelic loss in colon cancer
22. Deletions at chromosome 1p by fluorescence in situ hybridization are an early event in human colorectal tumorigenesis
23. Genetic instability and Darwinian selection in tumors