Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis

International Journal of Cancer

Volumn 119, Issue 11, 2006, Pages 2513-2519

  Ozaki, Kazuhide ^a   Nagasaka, Takeshi ^a   Notohara, Kenji ^a   Kambara, Takeshi ^a   Takeda, Masanori ^a   Sasamoto, Hiromi ^a   Jass, Jeremy R ^b   Tanaka, Noriaki ^a   Matsubara, Nagahide ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Colitic cancer; Microsatellite instability; Mismatch repair; Stroma; Ulcerative colitis

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P53;

ADULT; AGED; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MALE; MICROSATELLITE INSTABILITY; MICROSATELLITE MARKER; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; ULCERATIVE COLITIS;

ADOLESCENT; ADULT; AGED; BASE PAIR MISMATCH; COLITIS, ULCERATIVE; FEMALE; GENES, RAS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED;

EID: 33750632505     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22095     Document Type: Article

References (38)

1. Bargen JA. Chronic ulcerative colitis associated with malignant disease. Arch Surg 1928;17:561-76.
2. Devroede GJ, Taylor WF, Sauer WG, Jackman RJ, Stickler GB. Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med 1971;285:17-21.
3. Brostrom O, Lofberg R, Nordenvall B, Ost A, Hellers G. The risk of colorectal cancer in ulcerative colitis. An epidemiologic study. Scand J Gastroenterol 1987;22:1193-9.
4. Lashner BA, Silverstein MD, Hanauer SB. Hazard rates for dysplasia and cancer in ulcerative colitis. Results from a surveillance program. Dig Dis Sci 1989;34:1536-41.
5. Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 1990;323: 1228-33.
6. Sugita A, Sachar DB, Bodian C, Ribeiro MB, Aufses AH, Greenstein AJ. Colorectal cancer in ulcerative colitis. Influence of anatomical extent and age at onset on colitis-cancer interval. Gut 1991;32:167-9.
7. Collins RH, Jr, Feldman M, Fordtran JS. Colon cancer, dysplasia, and surveillance in patients with ulcerative colitis. A critical review. N Engl J Med 1987;316:1654-8.
8. Levin B. Inflammatory bowel disease and colon cancer. Cancer 1992;70:1313-16.
9. Lindberg B, Persson B, Veress B, Ingelman-Sundberg H, Granqvist S. Twenty years' colonoscopic surveillance of patients with ulcerative colitis. Detection of dysplastic and malignant transformation. Scand J Gastroenterol 1996;31:1195-204.
10. Blackstone MO, Riddell RH, Rogers BH, Levin B. Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy. Gastroenterology 1981;80:366-74.
11. Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, Ahren C, Correa P, Hamilton SR, Morson BC. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 1983;14:931-68.
12. Dobbins WO. III. Dysplasia and malignancy in inflammatory bowel disease. Annu Rev Med 1984;35:33-48.
13. Lennard-Jones JE, Melville DM, Morson BC, Ritchie JK, Williams CB. Precancet and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Gut 1990;31:800-6.
14. Riddell RH. The precarcinomatous phase of ulcerative colitis. Curt Top Pathol 1976;63:179-219.
15. Mir-Madjlessi SH, Farmer RG, Easley KA, Beck GJ. Colorectal and extracolonic malignancy in ulcerative colitis. Cancer 1986;58:1569-74.
16. Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 1996;56:1237-40.
17. Suzuki H, Harpaz N, Tarmin L, Yin J, Jiang HY, Bell JD, Hontanosas M, Groisman GM, Abraham JM, Meltzer SJ. Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers. Cancer Res 1994;54:4841-4.
18. Cravo ML, Albuquerque CM, Salazar de Sousa L, Gloria LM, Chaves P, Dias Pereira A, Nobre Leitao C, Quina MG, Costa Mira F. Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation. Am J Gastroenterol 1998;93:2060-4.
19. Park WS, Pham T, Wang C, Pack S, Mueller E, Mueller J, Vortmeyer A, Zhuang Z, Fogt F. Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis. Int J Mol Med 1998;2:221-4.
20. Willenbucher RF, Aust DE, Chang CG, Zelman SJ, Ferrell LD, Moore DH, Waldman FM. Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia. Am J Pathol 1999;154:1825-30.
21. Umetani N, Sasaki S, Watanabe T, Shinozaki M, Matsuda K, Ishigami H, Ueda E, Muto T. Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability. Jpn J Cancer Res 1999;90:1081-7.
22. Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, et al. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res 2000; 60:4864-8.
23. Ishitsuka T, Kashiwagi H, Konishi F. Microsatellite instability in inflamed and neoplastic epithelium in ulcerative colitis. J Clin Pathol 2001;54:526-32.
24. Whitehall VL, Walsh MD, Young J, Leggett BA, Jass JR. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res 2001;61:827-30.
25. Brentnall TA, Rubin CE, Crispin DA, Stevens A, Batchelor RH, Haggitt RC, Bronner MP, Evans JP, McCahill LE, Bilir N, Boland CR. A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative cojitis. Gastroenterology 1995;109:151-5.
26. Pokomy RM, Hofmeister A, Galandiuk S, Dietz AB, Cohen ND, Neibergs HL. Crohn's disease and ulcerative colitis are associated with the DNA repair gene MLH1. Ann Surg 1997;225:718-23.
27. Fogt F, Zimmerman RL, Poremba C, Noffsinger AE, Alsaigh N, Rueschoff J. Immunohistochemical screening of mismatch repair genes hMLH1, hMSH2, and hMSH6 in dysplastic lesions of the colon. Appl Immunohistochem Mol Morphol 2002;10:57-61.
28. Mao L, Lee DJ, Tockman MS, Erozan YS, Askin F, Sidransky D. Microsatellite alterations as clonal markers for the detection of human cancer. Proc Natl Acad Sci USA 1994;91:9871-5.
29. Barnetson R, Jass J, Tse R, Eckstein R, Robinson B, Schnitzler M. Mutations associated with microsatellite unstable colorectal carcinomas exhibit widespread intratumoral heterogeneity. Genes Chromosomes Cancer 2000;29:130-6.
30. Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science 1998;280:1036,1037.
31. Kambara T, Matsubara N, Nakagawa H, Notohara K, Nagasaka T, Yoshino T, Isozaki H, Sharp GB, Shimizu K, Jass J, Tanaka N. High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Res 2001;61:7743-6.
32. Oda S, Maehara Y, Ikeda Y, Oki E, Egashira A, Okamura Y, Takahashi I, Kakeji Y, Sumiyoshi Y, Miyashita K, Yamada Y, Zhao Y, et al. Two models of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. Nucleic Acids Res 2005;33:1628-36.
33. Jackson AL, Chen R, Loeb LA. Induction of microsatellite instability by oxidative DNA damage. Proc Natl Acad Sci USA 1998;95:12468-73.
34. Gasche C, Chang CL, Rhees J, Goel A, Boland CR. Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res 2001;61:7444-8.
35. Chang CL, Marra G, Chauhan DP, Ha HT, Chang DK, Ricciardiello L, Randolph A, Carethers JM, Boland CR. Oxidative stress inactivates the human DNA mismatch repair system. Am J Physiol Cell Physiol 2002;283:C148-C154.
36. Hofseth LJ, Khan MA, Ambrose M, Nikolayeva O, Xu-Welliver M, Kartalou M, Hussain SP, Roth RB, Zhou X, Mechanic LE, Zurer I, Rotter V, et al. The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation. J Clin Invest 2003;112:1887-94.
37. Woodford-Richens K, Bevan S, Churchman M, Dowling B, Jones D, Norbury CG, Hodgson SV, Desai D, Neale K, Phillips RK, Young J, Leggett B, et al. Analysis of genetic and phenotypic heterogeneity in juvenile polyposis. Gut 2000;46:656-60.
38. Matsumoto N, Yoshida T, Okayasu I. High epithelial and stromal genetic instability of chromosome 17 in ulcerative colitis-associated carcinogenesis. Cancer Res 2003;63:6158-61.