Functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse

Immunology Letters

Volumn 125, Issue 1, 2009, Pages 15-21

  Tóth, Ágnes ^a   Szilágyi, Orsolya ^a   Krasznai, Zoltán ^a   Panyi, György ^a   Hajdú, Péter ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Immunological synapse; Kv1.3 channels; Phosphorylation; Protein kinase

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DAMNACANTHAL; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; POTASSIUM CHANNEL KV1.3; PROTEIN KINASE C; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CELL INTERACTION; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; CYTOSOL; DEPOLARIZATION; ENZYME INACTIVATION; GENE REARRANGEMENT; MEMBRANE BINDING; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; STEADY STATE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH2 CELL; VOLTAGE CLAMP;

ANIMALS; ANTIGEN-PRESENTING CELLS; B-LYMPHOCYTES; CELL LINE; CELL LINE, TUMOR; IMMUNOLOGICAL SYNAPSES; ION CHANNEL GATING; KV1.3 POTASSIUM CHANNEL; MICE; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; TH2 CELLS;

EID: 67649964254     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2009.05.004     Document Type: Article

References (41)

1. Matteson D.R., and Deutsch C. K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion. Nature 307 (1984) 468-471
2. 2+ clearance distinguish Th1 and Th2 lymphocytes. J Immunol 164 (2000) 1153-1160
3. 2+ stores. Proc Natl Acad Sci USA 90 (1993) 6295-6299
4. Prakriya M., and Lewis R.S. CRAC channels: activation, permeation, and the search for a molecular identity. Cell Calcium 33 (2003) 311-321
5. + channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin. Proc Natl Acad Sci USA 89 (1992) 10094-10098
6. Fanger C.M., Rauer H., Neben A.L., Miller M.J., Wulff H., Rosa J.C., et al. Calcium-activated potassium channels sustain calcium signaling in T lymphocytes. Selective blockers and manipulated channel expression levels. J Biol Chem 276 (2001) 12249-12256
7. Panyi G., Gáspár R., Krasznai Z., ter Horst J.J., Ameloot M., Aszalós A., et al. Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes. Biochem Biophys Res Commun 221 (1996) 254-258
8. + channels and mitogenesis. Prog Clin Biol Res 334 (1990) 251-271
9. Koo G.C., Blake J.T., Talento A., Nguyen M., Lin S., Sirotina A., et al. Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J Immunol 158 (1997) 5120-5128
10. Price M., Lee S.C., and Deutsch C. Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes. Proc Natl Acad Sci USA 86 (1989) 10171-10175
11. Kalman K., Pennington M.W., Lanigan M.D., Nguyen A., Rauer H., Mahnir V., et al. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. J Biol Chem 273 (1998) 32697-32707
12. Garcia M.L., Gao Y., McManus O.B., and Kaczorowski G.J. Potassium channels: from scorpion venoms to high-resolution structure. Toxicon 39 (2001) 739-748
13. Bromley S.K., Burack W.R., Johnson K.G., Somersalo K., Sims T.N., Sumen C., et al. The immunological synapse. Annu Rev Immunol 19 (2001) 375-396
14. van der Merwe P.A. Formation and function of the immunological synapse. Curr Opin Immunol 14 (2002) 293-298
15. Davis D.M. Assembly of the immunological synapse for T cells and NK cells. Trends Immunol 23 (2002) 356-363
16. Panyi G., Bagdany M., Bodnar A., Vamosi G., Szentesi G., Jenei A., et al. Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes. Proc Natl Acad Sci USA 100 (2003) 2592-2597
17. Panyi G., Vamosi G., Bacso Z., Bagdany M., Bodnar A., Varga Z., et al. Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells. Proc Natl Acad Sci USA 101 (2004) 1285-1290
18. Beeton C., Wulff H., Standifer N.E., Azam P., Mullen K.M., Pennington M.W., et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci USA 103 (2006) 17414-17419
19. Nicolaou S.A., Szigligeti P., Neumeier L., Lee S.M., Duncan H.J., Kant S.K., et al. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus. J Immunol 179 (2007) 346-356
20. + channel in T lymphocytes upon Fas stimulation. J Biol Chem 271 (1996) 20465-20469
21. Bock J., Szabo I., Gamper N., Adams C., and Gulbins E. Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms. Biochem Biophys Res Commun 305 (2003) 890-897
22. Hanada T., Lin L., Chandy K.G., Oh S.S., and Chishti A.H. Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. J Biol Chem 272 (1997) 26899-26904
23. + channels as targets for specific immunomodulation. Trends Pharmacol Sci 25 (2004) 280-289
24. + channel Kv1.3. J Biol Chem 274 (1999) 20123-20126
25. Gong J., Xu J., Bezanilla M., van Huizen R., Derin R., and Li M. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science 285 (1999) 1565-1569
26. Monks C.R., Freiberg B.A., Kupfer H., Sciaky N., and Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395 (1998) 82-86
27. Hamill O.P., Marty A., Neher E., Sakmann B., and Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391 (1981) 85-100
28. Decoursey T.E., Chandy K.G., Gupta S., and Cahalan M.D. Two types of potassium channels in murine T lymphocytes. J Gen Physiol 89 (1987) 379-404
29. Decoursey T.E., Chandy K.G., Gupta S., and Cahalan M.D. Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol 89 (1987) 405-420
30. Hille B. Ion channels of excitable membranes (1992), Sinauer Associates Inc., Sunderland, MA
31. + channel in T cells. J Biol Chem 267 (1992) 20971-20979
32. Spencer R.H., Chandy K.G., and Gutman G.A. Immunological identification of the Shaker-related Kv1.3 potassium channel protein in T and B lymphocytes, and detection of related proteins in files and yeast. Biochem Biophys Res Commun 191 (1993) 201-206
33. Chung I., and Schlichter L.C. Native Kv1.3 channels are upregulated by protein kinase C. J Membr Biol 156 (1997) 73-85
34. Chung I., and Schlichter L.C. Regulation of native Kv1.3 channels by cAMP-dependent protein phosphorylation. Am J Physiol 273 (1997) C622-C633
35. Kwak Y.G., Hu N., Wei J., George Jr. A.L., Grobaski T.D., Tamkun M.M., et al. Protein kinase A phosphorylation alters Kvβ1.3 subunit-mediated inactivation of the Kv1.5 potassium channel. J Biol Chem 274 (1999) 13928-13932
36. + channel in Jurkat T lymphocytes by protein kinases A and C. J Biol Chem 267 (1992) 18270-18273
37. + channel to regulation by PKA and PKC is partially lost in HEK 293 host cells. J Membr Biol 161 (1998) 183-196
38. Bowlby M.R., Fadool D.A., Holmes T.C., and Levitan I.B. Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases. J Gen Physiol 110 (1997) 601-610
39. Holmes T.C., Fadool D.A., and Levitan I.B. Tyrosine phosphorylation of the Kv1.3 potassium channel. J Neurosci 16 (1996) 1581-1590
40. Storey N.M., Gomez-Angelats M., Bortner C.D., Armstrong D.L., and Cidlowski J.A. Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes. J Biol Chem 278 (2003) 33319-33326
41. Hajdu P., Varga Z., Pieri C., Panyi G., and Gaspar Jr. R. Cholesterol modifies the gating of Kv1.3 in human T lymphocytes. Pflugers Arch 445 (2003) 674-682