Synthesis of a series of novel dihydroartemisinin derivatives containing a substituted chalcone with greater cytotoxic effects in leukemia cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4385-4388

  Yang, Xuelin ^a   Wang, Wei ^a   Tan, Jun ^a   Song, Dandan ^a   Li, Ming ^a   Liu, Dan ^a   Jing, Yongkui ^b   Zhao, Linxiang ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Artemisinin; Leukemia; Structure activity relationships; Synthesis

Indexed keywords

ARTEMISININ; CHALCONE; DIHYDROARTEMISININ DERIVATIVE; DOXORUBICIN; ESTER; ETHER;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARTEMISININS; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA; MICE; MODELS, CHEMICAL;

EID: 67649962635     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.076     Document Type: Article

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