Prostanoid EP4 receptor stimulation produces ocular hypotension by a mechanism that does not appear to involve uveoscleral outflow

Investigative Ophthalmology and Visual Science

Volumn 50, Issue 7, 2009, Pages 3320-3328

  Woodward, David F ^a   Nilsson, Siv F E ^b   Toris, Carol B ^c   Kharlamb, Alexander B ^a   Nieves, Amelia L ^a   Krauss, Achim H P ^a,d  

^a ALLERGAN INC   (United States)

^b LINKÖPING UNIVERSITY   (Sweden)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,7 DITHIAPROSTAGLANDIN E1; 3,7 DITHIAPROSTAGLANDIN E1 ISOPROPYL ESTER; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG; 3,7 DITHIA(11 ALPHA,13E,15S) 11,15 DIHYDROXY 9 OXOPROST 13 EN 1 OIC ACID; 3,7-DITHIA(11 ALPHA,13E,15S)-11,15-DIHYDROXY-9-OXOPROST-13-EN-1-OIC ACID; ANTIHYPERTENSIVE AGENT; ATROPINE; BUTAPROST; DEXTRAN; DRUG DERIVATIVE; EP4 RECEPTOR; FLUORESCEIN ISOTHIOCYANATE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CILIARY MUSCLE; CONTROLLED STUDY; EYE BLOOD FLOW; FEMALE; GLAUCOMA; HUMAN; HUMAN TISSUE; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MALE; MONKEY; MORNING DOSAGE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SMOOTH MUSCLE RELAXATION; ANIMAL; AQUEOUS HUMOR; CILIARY BODY; DISEASE MODEL; DRUG EFFECT; DRUG POTENTIATION; FLUOROPHOTOMETRY; GENETIC TRANSFECTION; GENETICS; INTRAOCULAR HYPOTENSION; MACACA; METABOLISM; MUSCLE ISOMETRIC CONTRACTION; OCULOPLETHYSMOGRAPHY; PHYSIOLOGY; SCLERA; SECRETION; SMOOTH MUSCLE; UVEA;

ALPROSTADIL; ANIMALS; ANTERIOR CHAMBER; ANTIHYPERTENSIVE AGENTS; AQUEOUS HUMOR; ATROPINE; CILIARY BODY; DEXTRANS; DINOPROSTONE; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUOROPHOTOMETRY; HUMANS; INTRAOCULAR PRESSURE; ISOMETRIC CONTRACTION; MACACA FASCICULARIS; MUSCLE, SMOOTH; OCULAR HYPOTENSION; RECEPTORS, PROSTAGLANDIN E; SCLERA; TONOMETRY, OCULAR; TRANSFECTION; UVEA;

EID: 67649961681     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.08-3031     Document Type: Article

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