Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype

Prostaglandins and Other Lipid Mediators

Volumn 65, Issue 4, 2001, Pages 167-187

  Castleberry, Tessa A ^a   Lu, Bihong ^a   Smock, Steven L ^a   Owen, Thomas A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTAPROST; CELL DNA; COMPLEMENTARY DNA; CYCLIC AMP; PROSTAGLANDIN A; PROSTAGLANDIN A3; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2; RECEPTOR SUBTYPE; SULPROSTONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA LIBRARY; DOG; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GENE ISOLATION; GENETIC TRANSFECTION; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; ORGAN DISTRIBUTION; RECEPTOR DOWN REGULATION; SECOND MESSENGER; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CYCLIC AMP; DINOPROSTONE; DOGS; FORSKOLIN; HUMANS; MOLECULAR SEQUENCE DATA; PROSTAGLANDINS A; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, PROSTAGLANDIN E; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

EID: 0034973610     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(01)00129-0     Document Type: Article

References (58)

1. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes
2. The role of prostaglandins in the regulation of bone metabolism
3. Prostanoid receptors: Structures, properties, and functions
4. Cloning and expression of a cDNA for the human prostaglandin receptor EP1 subtype
5. Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor
6. Two isoforms of the EP3 receptor with different carboxyl-terminal domains
7. A prostaglandin E receptor coupled to a pertussis toxin sensitive guanine nucleotide regulatory protein in rabbit cortical collecting tubule cells
8. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype
9. Effects of EP-receptor subtype specific agonists and other prostanoids on adenylate cyclase activity of duodenal epithelial cells
10. Identification of prostaglandin E receptor 'EP2′ cloned from mastocytoma cells as EP4 subtype
11. A novel inhibitory prostanoid receptor in piglet saphenous vein
12. 2 stimulates preosteoblast replication: An autoradiographic study in cultured fetal rat calvariae
13. 2 on bone formation in cultured fetal rat calvariae: Interaction with cortisol
14. The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: An analysis using specific agonists for the respective EPs
15. Prostaglandins and the skeleton: The legacy and challenges of two decades of research
16. 2 receptor EP4 subtype is essential for agonist-induced desensitization
17. Presence of messenger ribonucleic acid encoding osteocalcin, a marker of bone turnover, in bone marrow megakaryocytes and peripheral blood platelets
18. Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype
19. Identification of a region of the C-terminal domain involved in short-term desensitization of the prostaglandin EP4 receptor
20. A rapid, and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
21. The scanning model for translation: An update
22. A simple method for displaying the hydropathic character of a protein
23. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2
24. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype
25. Structural requirements of N-glycosylation of proteins
26. Synthesis and processing of asparagine-linked oligosaccharides
27. Sequence-, and structure-based prediction of eukaryotic protein phosphorylation sites
28. Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases
29. Regulatory mechanisms that modulate signalling by G-protein-coupled receptors
30. Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E2 receptor hybrid
31. Cloning and expression of the rabbit prostaglandin EP4 receptor
32. The structure of the prostaglandin EP4 receptor gene and related pseudogenes
33. Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype
34. Prostanoid receptors of murine NIH 3T3 and RAW 264.7 cells
35. G protein-coupled receptors: I. Diversity of receptor-ligand interactions
36. Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites
37. A single amino-acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs
38. Substitution of charged amino acid residues in transmembrane regions 6 and 7 affect ligand binding and signal transduction of the prostaglandin EP3 receptor
39. 2 receptor EP3 subtype in insect cells
40. 2 receptor EP3α subtype
41. Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype
42. Identification of domains conferring ligand binding specificity to the prostanoid receptor
43. The second extracellular loop of the prostaglandin EP3 receptor is an essential determinant of ligand selectivity
44. A conserved threonine in the second extracellular loop of the human EP2, and EP4 receptors is required for ligand binding
45. Importance of the extracellular domain for prostaglandin EP2 receptor function
46. 2 receptor EP3α subtype: The role of N-glycosylation in ligand binding as revealed by site-directed mutagenesis
47. The role of N-glycosylation of human thromboxane A2 receptor in ligand binding
48. Mutational analysis of β-adrenergic receptor glycosylation
49. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors
50. Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: Pharmacological characterization
51. Genetics of somatic mammalian cells: Long-term cultivation of euploid cells from human and animal subjects
52. Two Gs-coupled prostaglandin E receptor subtypes, EP2, and EP4, differ in desensitization, and sensitivity to the metabolic inactivation of the agonist
53. The C-terminal domain of the human EP4 receptor confers agonist-induced desensitization in a receptor hybrid with the rat EP3β receptor
54. Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor
55. Role of C-terminal serines in desensitization and phosphorylation of the mouse thromboxane receptor
56. Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
57. Phosphorylation of the prostacyclin receptor during homologous desensitization
58. G protein-coupled receptors: III. New roles for receptor kinases, and β-arrestins in receptor signaling, and desensitization