Structure-activity relationships and receptor profiles of some ocular hypotensive prostanoids

Survey of Ophthalmology

Volumn 41, Issue SUPPL. 2, 1997, Pages

  Resul, B ^a   Stjernschantz, J ^a   Selen, G ^a   Bito, L ^a  

^a Pharmacia & Upjohn AB   (Sweden)

Author keywords

cat; FP receptors; intraocular pressure; irritation; latanoprost; monkey; prostaglandins; structure activity relationships

Indexed keywords

EYE DROPS; LATANOPROST; PRODRUG; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN F2 ALPHA DERIVATIVE; PROSTAGLANDIN F2 ALPHA ISOPROPYL ESTER; PROSTANOID; PROSTANOID RECEPTOR;

CAT; CONFERENCE PAPER; CONJUNCTIVA DISEASE; DRUG EFFICACY; DRUG POTENCY; EYE IRRITATION; GLAUCOMA; INTRAOCULAR PRESSURE; MIOSIS; MONKEY; NONHUMAN; PRIORITY JOURNAL; RABBIT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; TOPICAL DRUG ADMINISTRATION;

EID: 0031004172     PISSN: 00396257     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0039-6257(97)80007-0     Document Type: Conference Paper

References (16)

1. 2α and its isopropyl ester on normal and glaucomatous human eyes LZ Bito J Stjernschantz The Ocular Effects of Prostaglandins and Other Eicosanoids 1989 Alan R. Liss Inc New York 447 458
2. A Aim CB Camras PG Watson Phase III latanoprost studies in Scandinavia, the United Kingdom and the United States Surv Ophthalmol 41 Suppl 2 1997 S105 S110
3. LZ Bito Species differences in the responses of the eye to irritation and trauma Exp Eye Res 38 1984 181 194
4. LZ Bito C Camras G Gum B Resul The ocular hypotensive effects and side effects of prostaglandins on the eyes of experimental animals LZ Bito J Stjernschantz The Ocular Effects of Prostaglandins and Other Eicosanoids 1989 Alan R. Liss Inc New York 349 368
5. 2α analogue, PhXA41 (latanoprost), for glaucoma management J Lipid Mediators 6 1993 535 543
6. CB Camras A Alto Initial clinical studies with prostaglandins and their analogues Surv Ophthalmol 41 Suppl 2 1997 S61 S68
7. RA Coleman I Kennedy PPA Humphrey Prostaglanoid and their receptors C Hansch PG Sammes JB Taylor Comprehensive Medicinal Chemistry 1989 Pergamon Press Oxford/New York 643 714
8. EL Greve AH Rulo PFJ Hoyng Reduced intraocular pressure and increased ocular perfusion pressure in normal tension glaucoma: A review of short-term studies with three dose regimens of latanoprost treatment Surv Ophthalmol 41 Suppl 2 1997 S89 S92
9. 2α in the human eye Graefe's Arch Clin Exp Ophthalmol 222 1985 139 141
10. OC Miranda LZ Bito The putative and demonstrated miotic effects of prostaglandins in mammals LZ Bito J Stjernschantz The Ocular Effects of Prostaglandins and Other Eicosanoids 1989 Alan R. Liss Inc New York 171 195
11. HK Mishima Y Kiuchi M Takamatsu et al: Circadian intraocular pressure management with latanoprost: Diurnal and nocturnal intraocular pressure reduction and increased uveoscleral outflow Surv Ophthalmol 41 Suppl 2 1997 S139 S144
12. 2α-i-Pr ester in the cynomolgus monkeys J Exp Eye Res 48 1989 707 716
13. B Resul J Stjernschantz K No et al: Phenyl substituted prostaglandins: Potent and selective antiglaucoma agents J Med Chem 36 1993 243 248
14. 2α on cat and rhesus monkey eyes Invest Ophthalmol Visual Sci 22 1982 588 598
15. J Stjernschantz Resul B: Phenyl substituted prostaglandin analogues for glaucoma treatment Drugs Future 17 1992 691 704
16. 2α analogue Adv in Prostaglandin, Thromboxane, and Leukotriene Res 23 1995 513 518