Levels of evidence for the treatment of keloid disease

Journal of Plastic, Reconstructive and Aesthetic Surgery

Volumn 61, Issue 1, 2008, Pages 4-17

  Durani, P ^a   Bayat, A ^b  

^a Renovo   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Keloid disease; Keloid scarring; Levels of evidence; Management; Prevention; Therapy

Indexed keywords

ALPHA INTERFERON; ALPHA TOCOPHEROL; ALPHA2B INTERFERON; BLEOMYCIN; COLCHICINE; CORTICOSTEROID; DEXAMETHASONE; FLUOROURACIL; GAMMA INTERFERON; HYDROCORTISONE ACETATE; IMIQUIMOD; METHYLPREDNISOLONE; METHYLPREDNISOLONE ACETATE; MITOMYCIN C; PLACEBO; RETINOIC ACID; SILICONE; TRIAMCINOLONE; TRIAMCINOLONE ACETATE; TRIAMCINOLONE ACETONIDE; VERAPAMIL;

ADJUVANT THERAPY; CLINICAL STUDY; CRYOSURGERY; DECISION MAKING; EVIDENCE BASED MEDICINE; KELOID; LOW LEVEL LASER THERAPY; MEDICAL RESEARCH; MEDLINE; MONOTHERAPY; NONHUMAN; PHYSICIAN; PRIORITY JOURNAL; REVIEW;

COMBINED MODALITY THERAPY; EVIDENCE-BASED MEDICINE; GLUCOCORTICOIDS; HUMANS; INJECTIONS, INTRALESIONAL; KELOID; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SILICONE GELS;

EID: 36649026344     PISSN: 17486815     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bjps.2007.05.007     Document Type: Review

References (148)

1. A first class service: quality in the new NHS (1998), Department of Health, London (Health Service Circular: HSC(98) 113)
2. Bayat A., McGrouther D.A., and Ferguson M.W. Skin scarring. BMJ 326 (2003) 88-92
3. Ehrlich H.P., Desmouliere A., Diegelmann R.F., et al. Morphological and immunochemical differences between keloid and hypertrophic scar. Am J Pathol 145 (1994) 105-113
4. Bayat A., and McGrouther D.A. Clinical management of skin scarring. Skinmed 4 (2005) 165-173
5. Murray J.C. Keloids and hypertrophic scars. Clin Dermatol 12 (1994) 27-37
6. Mustoe T.A., Cooter R.D., Gold M.H., et al. International Advisory Panel on Scar Management. International clinical recommendations on scar management. Plast Reconstr Surg 110 (2002) 560-571
7. Kiil J. Keloids treated with topical injections of triamcinolone acetonide (kenalog). Immediate and long-term results. Scand J Plast Reconstr Surg 11 (1977) 169-172
8. Griffith B.H., Monroe C.W., and McKinney P. A follow-up study on the treatment of keloids with triamicinolone acetonide. Plast Reconstr Surg 46 (1970) 145-150
9. Niessen F.B., Spauwen P.H., Schalkwijk J., et al. On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg 104 (1999) 1435-1458
10. Shaffer J.J., Taylor S.C., and Cook-Bolden F. Keloidal scars: a review with a critical look at therapeutic options. J Am Acad Dermatol 46 Suppl. Understanding (2002) S63-S97
11. Kelly A.P. Medical and surgical therapies for keloids. Dermatol Ther 17 (2004) 212-218
12. Al-Attar A., Mess S., Thomassen J.M., et al. Keloid pathogenesis and treatment. Plast Reconstr Surg 117 (2006) 286-300
13. Ball C., Sackett D., Phillips B., et al. Levels of Evidence and Grades of Recommendation (2001), Centre for Evidence-Based Medicine, Oxford. http://www.cebm.net/levels_of_evidence.asp
14. Sawada Y., and Sone K. Treatment of scars and keloids with a cream containing silicone oil. Br J Plast Surg 43 (1990) 683-688
15. Palmieri B., Gozzi G., and Palmieri G. Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids. Int J Derm 34 (1995) 506-509
16. Sawada Y., and Sone K. Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg 45 (1992) 599-603
17. Chang C.C., Kuo Y.F., Chiu H.C., et al. Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts. J Surg Res 59 (1995) 705-711
18. Gold M.H. A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. J Am Acad Dermatol 30 (1994) 506-507
19. de Oliveira G.V., Nunes T.A., Magna L.A., et al. Silicone versus nonsilicone gel dressings: a controlled trial. Dermatol Surg 27 (2001) 721-726
20. Berman B., and Flores F. Comparison of a silicone gel-filled cushion and silicon gel sheeting for the treatment of hypertrophic or keloid scars. Dermatol Surg 25 (1999) 484-486
21. Fulton Jr. J.E. Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol Surg 21 (1995) 947-951
22. Gold M.H. Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. A dermatologic experience. J Dermatol Surg Oncol 19 (1993) 912-916
23. Dockery G.L., and Nilson R.Z. Treatment of hypertrophic and keloid scars with silastic gel sheeting. J Foot Ankle Surg 33 (1994) 110-119
24. Mercer N.S. Silicone gel in the treatment of keloid scars. Br J Plast Surg 42 (1989) 83-87
25. Quinn K.J. Silicone gel in scar treatment. Burns Incl Therm Inj 13 Suppl. (1987) S33-S40
26. Ohmori S. Effectiveness of silastic sheet coverage in the treatment of scar keloid (hypertrophic scar). Aesthetic Plast Surg 12 (1988) 95-99
27. Chuangsuwanich A., Osathalert V., and Muangsombut S. Self-adhesive silicone gel sheet: a treatment for hypertrophic scars and keloids. J Med Assoc Thai 83 (2000) 439-444
28. Hirshowitz B., Lindenbaum E., Har-Shai Y., et al. Static-electric field induction by a silicone cushion for the treatment of hypertrophic and keloid scars. Plast Reconstr Surg 101 (1998) 1173-1183
29. Wong T.W., Chiu H.C., Chang C.H., et al. Silicone cream occlusive dressing - a novel noninvasive regimen in the treatment of keloid. Dermatology 192 (1996) 329-333
30. Katz B.E. Silicone gel sheeting in scar therapy. Cutis 56 (1995) 65-67
31. O'Brien L., and Pandit A. Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev (2006) CD003826
32. McCoy B.J., Diegelmann R.F., and Cohen I.K. In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med 163 (1980) 216-222
33. Cruz N.I., and Korchin L. Inhibition of human keloid fibroblast growth by isotretinoin and triamcinolone acetonide in vitro. Ann Plast Surg 33 (1994) 401-405
34. Boyadjiev C., Popchristova E., and Mazgalova J. Histomorphologic changes in keloids treated with Kenacort. J Trauma 38 (1995) 299-302
35. Kauh Y.C., Rouda S., Mondragon G., et al. Major suppression of pro-alpha1(I) type I collagen gene expression in the dermis after keloid excision and immediate intrawound injection of triamcinolone acetonide. J Am Acad Dermatol 37 (1997) 586-589
36. Darzi M.A., Chowdri N.A., Kaul S.K., et al. Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. Br J Plast Surg 45 (1992) 374-379
37. Layton A.M., Yip J., and Cunliffe W.J. A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. Br J Dermatol 130 (1994) 498-501
38. Yosipovitch G., Widijanti Sugeng M., Goon A., et al. A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study. J Dermatolog Treat 12 (2001) 87-90
39. Manuskiatti W., and Fitzpatrick R.E. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138 (2002) 1149-1155
40. Boutli-Kasapidou F., Tsakiri A., Anagnostou E., et al. Hypertrophic and keloidal scars: an approach to polytherapy. Int J Dermatol 44 (2005) 324-327
41. Muneuchi G., Suzuki S., Onodera M., et al. Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients. Scand J Plast Reconstr Surg Hand Surg 40 (2006) 111-116
42. Lahiri A., Tsiliboti D., and Gaze N.R. Experience with difficult keloids. Br J Plast Surg 54 (2001) 633-635
43. Hirshowitz B., Lerner D., and Moscona A.R. Treatment of keloid scars by combined cryosurgery and intralesional corticosteroids. Aesthetic Plast Surg 6 (1982) 153-158
44. Russell R., Horlock N., and Gault D. Zimmer splintage: a simple effective treatment for keloids following ear-piercing. Br J Plast Surg 54 (2001) 509-510
45. Connell P.G., and Harland C.C. Treatment of keloid scars with pulsed dye laser and intralesional steroid. J Cutan Laser Ther 2 (2000) 147-150
46. Fitzpatrick R.E. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 25 (1999) 224-232
47. Yencha M.W., and Oberman J.P. Combined therapy in the treatment of auricular keloids. Ear Nose Throat J 85 (2006) 93-94 [96-7]
48. Har-Shai Y., Amar M., and Sabo E. Intralesional cryotherapy for enhancing the involution of hypertrophic scars and keloids. Plast Reconstr Surg 111 (2003) 1841-1852
49. Shepherd J.P., and Dawber R.P. The response of keloid scars to cryosurgery. Plast Reconstr Surg 70 (1982) 677-682
50. Muti E., and Ponzio E. Cryotherapy in the treatment of keloids. Ann Plast Surg 11 (1983) 227-232
51. Rusciani L., Rossi G., and Bono R. Use of cryotherapy in the treatment of keloids. J Dermatol Surg Oncol 19 (1993) 529-534
52. Zouboulis C.C., Blume U., Buttner P., et al. Outcomes of cryosurgery in keloids and hypertrophic scars. A prospective consecutive trial of case series. Arch Dermatol 129 (1993) 1146-1151
53. Gupta S., and Kumar B. Intralesional cryosurgery using lumbar puncture and/or hypodermic needles for large, bulky, recalcitrant keloids. Int J Derm 40 (2001) 349-353
54. Fikrle T., and Pizinger K. Cryosurgery in the treatment of earlobe keloids: report of seven cases. Dermatol Surg 31 (2005) 1728-1731
55. de Waard J.W., de Man B.M., Wobbes T., et al. Inhibition of fibroblast collagen synthesis and proliferation by levamisole and 5-fluorouracil. Eur J Cancer 34 (1998) 162-167
56. Blumenkranz M., Hernandez E., Ophir A., et al. 5-Fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology 91 (1984) 122-130
57. Gupta S., and Kalra A. Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids. Dermatology 204 (2002) 130-132
58. Nanda S., and Reddy B.S. Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatol Surg 30 (2004) 54-56
59. Apikian M., and Goodman G. Intralesional 5-fluorouracil in the treatment of keloid scars. Australas J Dermatol 45 (2004) 140-143
60. Kontochristopoulos G., Stefanaki C., Panagiotopoulos A., et al. Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol 52 (2005) 474-479
61. Jimenez S.A., Freundlich B., and Rosenbloom J. Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest 74 (1984) 1112-1116
62. Berman B., and Duncan M.R. Short-term keloid treatment in vivo with human interferon alfa-2b results in a selective and persistent normalization of keloidal fibroblast collagen, glycosaminoglycan, and collagenase production in vitro. J Am Acad Dermatol 21 (1989) 694-702
63. Granstein R.D., Rook A., Flotte T.J., et al. A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring. Cinical and histologic findings. Arch Dermatol 126 (1990) 1295-1302
64. al-Khawajah M.M. Failure of interferon-alpha 2b in the treatment of mature keloids. Int J Dermatol 35 (1996) 515-517
65. Larrabee Jr. W.F., East C.A., Jaffe H.S., et al. Intralesional interferon gamma treatment for keloids and hypertrophic scars. Arch Otolaryngol Head Neck Surg 116 (1990) 1159-1162
66. Conejo-Mir J.S., Corbi R., and Linares M. Carbon dioxide laser ablation associated with interferon alfa-2b injections reduces the recurrence of keloids. J Am Acad Dermatol 39 (1998) 1039-1040
67. Alster T.S., and Williams C.M. Treatment of keloid sternotomy scars with 585 nm flashlamp-pumped pulsed-dye laser. Lancet 345 (1995) 1198-1200
68. Paquet P., Hermanns J.F., and Pierard G.E. Effect of the 585 nm flashlamp-pumped pulsed dye laser for the treatment of keloids. Dermatol Surg 27 (2001) 171-174
69. Dierickx C., Goldman M.P., and Fitzpatrick R.E. Laser treatment of erythematous/hypertrophic and pigmented scars in 26 patients. Plast Reconstr Surg 95 (1995) 84-90
70. Abergel R.P., Dwyer R.M., Meeker C.A., et al. Laser treatment of keloids: a clinical trial and an in vitro study with Nd:YAG laser. Lasers Surg Med 4 (1984) 291-295
71. Sherman R., and Rosenfeld H. Experience with the Nd:YAG laser in the treatment of keloid scars. Ann Plast Surg 21 (1988) 231-235
72. Kumar K., Kapoor B.S., Rai P., et al. In-situ irradiation of keloid scars with Nd:YAG laser. J Wound Care 9 (2000) 213-215
73. Henderson D.L., Cromwell T.A., and Mes L.G. Argon and carbon dioxide laser treatment of hypertrophic and keloid scars. Lasers Surg Med 3 (1984) 271-277
74. Kantor G.R., Wheeland R.G., Bailin P.L., et al. Treatment of earlobe keloids with carbon dioxide laser excision: a report of 16 cases. J Dermatol Surg Oncol 11 (1985) 1063-1067
75. Stucker F.J., and Shaw G.Y. An approach to management of keloids. Arch Otolaryngol Head Neck Surg 118 (1992) 63-67
76. Apfelberg D.B., Maser M.R., White D.N., et al. Failure of carbon dioxide laser excision of keloids. Lasers Surg Med 9 (1989) 382-388
77. Stern J.C., and Lucente F.E. Carbon dioxide laser excision of earlobe keloids. A prospective study and critical analysis of existing data. Arch Otolaryngol Head Neck Surg 115 (1989) 1107-1111
78. Norris J.E. The effect of carbon dioxide laser surgery on the recurrence of keloids. Plast Reconstr Surg 87 (1991) 44-49
79. Hulsbergen Henning J.P., Roskam Y., and van Gemert M.J. Treatment of keloids and hypertrophic scars with an argon laser. Lasers Surg Med 6 (1986) 72-75
80. Apfelberg D.B., Maser M.R., Lash H., et al. Preliminary results of argon and carbon dioxide laser treatment of keloid scars. Lasers Surg Med 4 (1984) 283-290
81. Lee Y., Minn K.W., Baek R.M., et al. A new surgical treatment of keloid: keloid core excision. Ann Plast Surg 46 (2001) 135-140
82. Lawrence W.T. In search of the optimal treatment of keloids: report of a series and a review of the literature. Ann Plast Surg 27 (1991) 164-178
83. Shons A.R., and Press B.H. The treatment of earlobe keloids by surgical excision and postoperative triamcinolone injection. Ann Plast Surg 10 (1983) 480-482
84. Golladay E.S. Treatment of keloids by single intraoperative perilesional injection of repository steroid. South Med J 81 (1988) 736-738
85. Tang Y.W. Intra- and postoperative steroid injections for keloids and hypertrophic scars. Br J Plast Surg 45 (1992) 371-373
86. Chowdri N.A., Masarat M., Mattoo A., et al. Keloids and hypertrophic scars: results with intraoperative and serial postoperative corticosteroid injection therapy. Aust N Z J Surg 69 (1999) 655-659
87. Talmi Y.P., Orenstein A., Wolf M., et al. Use of mitomycin C for treatment of keloid: a preliminary report. Otolaryngol Head Neck Surg 132 (2005) 598-601
88. Sanders K.W., Gage-White L., and Stucker F.J. Topical mitomycin C in the prevention of keloid scar recurrence. Arch Facial Plast Surg 7 (2005) 172-175
89. Copcu E., Sivrioglu N., and Oztan Y. Combination of surgery and intralesional verapamil injection in the treatment of the keloid. J Burn Care Rehabil 25 (2004) 1-7
90. Rehman J., Benet A., and Melman A. Use of intralesional verapamil to dissolve Peyronie's disease plaque: a long-term single-blind study. Urology 51 (1998) 620-626
91. Lawrence W.T. Treatment of earlobe keloids with surgery plus adjuvant intralesional verapamil and pressure earrings. Ann Plast Surg 37 (1996) 167-169
92. D'Andrea F., Brongo S., Ferraro G., et al. Prevention and treatment of keloids with intralesional verapamil. Dermatology 204 (2002) 60-62
93. Broker B.J., Rosen D., Amsberry J., et al. Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: a pilot study. Laryngoscope 106 (1996) 1497-1501
94. Davison S.P., Mess S., Kauffman L.C., et al. Ineffective treatment of keloids with interferon alpha-2b. Plast Reconstr Surg 117 (2006) 247-252
95. Berman B., and Flores F. Recurrence rates of excised keloids treated with postoperative triamcinolone acetonide injections or interferon alfa-2b injections. J Am Acad Dermatol 37 (1997) 755-757
96. Uppal R.S., Khan U., Kakar S., et al. The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. Plast Reconstr Surg 108 (2001) 1218-1224
97. Berman B., and Kaufman J. Pilot study of the effect of postoperative imiquimod 5% cream on the recurrence rate of excised keloids. J Am Acad Dermatol 47 Suppl. 4 (2002) S209-S211
98. Martin-Garcia R.F., and Busquets A.C. Postsurgical use of imiquimod 5% cream in the prevention of earlobe keloid recurrences: results of an open-label, pilot study. Dermatol Surg 31 (2005) 1394-1398
99. Brent B. The role of pressure therapy in management of earlobe keloids: preliminary report of a controlled study. Ann Plast Surg 1 (1978) 579-581
100. Rauscher G.E., and Kolmer W.L. Treatment of recurrent earlobe keloids. Cutis 37 (1986) 67-68
101. Sclafani A.P., Gordon L., Chadha M., et al. Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature. Dermatol Surg 22 (1996) 569-574
102. Ollstein R.N., Siegel H.W., Gillooley J.F., et al. Treatment of keloids by combined surgical excision and immediate postoperative X-ray therapy. Ann Plast Surg 7 (1981) 281-285
103. Enhamre A., and Hammar H. Treatment of keloids with excision and postoperative X-ray irradiation. Dermatologica 167 (1983) 90-93
104. Borok T.L., Bray M., Sinclair I., et al. Role of ionizing irradiation for 393 keloids. Int J Radiat Oncol Biol Phys 15 (1988) 865-870
105. Kovalic J.J., and Perez C.A. Radiation therapy following keloidectomy: a 20-year experience. Int J Radiat Oncol Biol Phys 17 (1989) 77-80
106. Sallstrom K.O., Larson O., Heden P., et al. Treatment of keloids with surgical excision and postoperative X-ray radiation. Scand J Plast Reconstr Surg Hand Surg 23 (1989) 211-215
107. Doornbos J.F., Stoffel T.J., Hass A.C., et al. The role of kilovoltage irradiation in the treatment of keloids. Int J Radiat Oncol Biol Phys 18 (1990) 833-839
108. Chen H.C., Ou S.Y., and Lai Y.L. Combined surgery and irradiation for treatment of hypertrophic scars and keloids. Chin Med J 47 (1991) 249-254
109. Supe S.S., Supe S.J., Rao S.M., et al. Treatment of keloids by 90Sr--90Y beta-rays. Strahlenther Onkol 167 (1991) 397-402
110. Ship A.G., Weiss P.R., Mincer F.R., et al. Sternal keloids: successful treatment employing surgery and adjunctive radiation. Ann Plast Surg 31 (1993) 481-487
111. Escarmant P., Zimmermann S., Amar A., et al. The treatment of 783 keloid scars by iridium 192 interstitial irradiation after surgical excision. Int J Radiat Oncol Biol Phys 26 (1993) 245-251
112. Klumpar D.I., Murray J.C., and Anscher M. Keloids treated with excision followed by radiation therapy. J Am Acad Dermatol 31 (1994) 225-231
113. Chaudhry M.R., Akhtar S., Duvalsaint F., et al. Ear lobe keloids, surgical excision followed by radiation therapy: a 10-year experience. Ear Nose Throat J 73 (1994) 779-781
114. Durosinmi-Etti F.A., Olasinde T.A., and Solarin E.O. A short course postoperative radiotherapy regime for keloid scars in Nigeria. West Afr J Med 13 (1994) 17-19
115. Norris J.E. Superficial X-ray therapy in keloid management: a retrospective study of 24 cases and literature review. Plast Reconstr Surg 95 (1995) 1051-1055
116. Clavere P., Bedane C., Bonnetblanc J.M., et al. Postoperative interstitial radiotherapy of keloids by iridium 192: a retrospective study of 46 treated scars. Dermatology 195 (1997) 349-352
117. Wagner W., Alfrink M., Micke O., et al. Results of prophylactic irradiation in patients with resected keloids - a retrospective analysis. Acta Oncol 39 (2000) 217-220
118. Guix B., Henriquez I., Andres A., et al. Treatment of keloids by high-dose-rate brachytherapy: a seven-year study. Int J Radiat Oncol Biol Phys 50 (2001) 167-172
119. Ragoowansi R., Cornes P.G., Glees J.P., et al. Ear-lobe keloids: treatment by a protocol of surgical excision and immediate postoperative adjuvant radiotherapy. Br J Plast Surg 54 (2001) 504-508
120. Caccialanza M., Piccinno R., and Schiera A. Postoperative radiotherapy of keloids: a twenty-year experience. Eur J Dermatol 12 (2002) 58-62
121. Maarouf M., Schleicher U., Schmachtenberg A., et al. Radiotherapy in the management of keloids. Clinical experience with electron beam irradiation and comparison with X-ray therapy. Strahlenther Onkol 178 (2002) 330-335
122. Ragoowansi R., Cornes P.G., Moss A.L., et al. Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy. Plast Reconstr Surg 111 (2003) 1853-1859
123. Ogawa R., Mitsuhashi K., Hyakusoku H., et al. Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months. Plast Reconstr Surg 111 (2003) 547-553
124. Garg M.K., Weiss P., Sharma A.K., et al. Adjuvant high dose rate brachytherapy (Ir-192) in the management of keloids which have recurred after surgical excision and external radiation. Radiother Oncol 73 (2004) 233-236
125. Malaker K., Zaidi M., and Franka M.R. Treatment of earlobe keloids using the cobalt 60 teletherapy unit. Ann Plast Surg 52 (2004) 602-604
126. Fraunholz I.B., Gerstenhauer A., and Bottcher H.D. Results of postoperative (90)Sr radiotherapy of keloids in view of patients' subjective assessment. Strahlenther Onkol 181 (2005) 724-729
127. Lindsey W.H., and Davis P.T. Facial keloids. A 15-year experience. Arch Otolaryngol Head Neck Surg 123 (1997) 397-400
128. Agrawal K., Panda K.N., and Arumugam A. An inexpensive self fabricated pressure clip for the ear lobe. Br J Plast Surg 51 (1998) 122-123
129. Akoz T., Gideroglu K., and Akan M. Combination of different techniques for the treatment of earlobe keloids. Aesthetic Plast Surg 26 (2002) 184-188
130. Malaker K., Vijayraghavan K., Hodson I., et al. Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. Clin Oncol (R Coll Radiol) 16 (2004) 290-298
131. Espana A., Solano T., and Quintanilla E. Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol Surg 27 (2001) 23-27
132. Saray Y., and Gulec A.T. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Derm 44 (2005) 777-784
133. Janssen de Limpens A.M. The local treatment of hypertrophic scars and keloids with topical retinoic acid. Br J Dermatol 103 (1980) 319-323
134. Panabiere-Castaings M.H. Retinoic acid in the treatment of keloids. J Dermatol Surg Oncol 14 (1988) 1275-1276
135. Soderberg T., Hallmans G., and Bartholdson L. Treatment of keloids and hypertrophic scars with adhesive zinc tape. Scand J Plast Reconstr Surg 16 (1982) 261-266
136. Phillips T.J., Gerstein A.D., and Lordan V. A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids. Dermatol Surg 22 (1996) 775-778
137. Kunz R., and Oxman A.D. The unpredictability paradox: review of empirical comparisons of randomised and non-randomised clinical trials. BMJ 317 (1998) 1185-1190
138. Offer G.J., and Perks A.G. In search of evidence-based plastic surgery: the problems faced by the specialty. Br J Plast Surg 53 (2000) 427-433
139. Bayat A., Arscott G., Ollier W.E., et al. Description of site-specific morphology of keloid phenotypes in an Afrocaribbean population. Br J Plast Surg 57 (2004) 122-133
140. Bayat A., Arscott G., Ollier W.E., et al. Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg 58 (2005) 28-37
141. Bayat A., Arscott G., Ollier W.E., et al. "Aggressive keloid": a severe variant of familial keloid scarring. J R Soc Med 96 (2003) 554-555
142. Burd A., and Huang L. Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg 116 (2005) 150e-157e
143. Beausang E., Floyd H., Dunn K.W., et al. A new quantitative scale for clinical scar assessment. Plast Reconstr Surg 102 (1998) 1954-1961
144. van de Kar A.L., Corion L.U., Smeulders M.J., et al. Reliable and feasible evaluation of linear scars by the patient and observer scar assessment scale. Plast Reconstr Surg 116 (2005) 514-522
145. Draaijers L.J., Tempelman F.R., Botman Y.A., et al. Colour evaluation in scars: tristimulus colorimeter, narrow-band simple reflectance meter or subjective evaluation?. Burns 30 (2004) 103-107
146. Taylor B., McGrouther D.A., and Bayat A. Use of a non-contact 3D digitiser to measure the volume of keloid scars: a useful tool for scar assessment. J Plast Reconstr Aesthet Surg 60 (2007) 87-94
147. Moher D., Schulz K.F., and Altman D.G. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 357 (2001) 1191-1194
148. Gerritsen A.A., de Vet H.C., Scholten R.J., et al. Enabling meta-analysis in systematic reviews on carpal tunnel syndrome. J Hand Surg [Am] 27 (2002) 828-832