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Volumn 19, Issue 15, 2009, Pages 4416-4420

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Author keywords

Autoimmune disease; Colchicine; Cyclosporin A; Graft rejection; Immunosuppressant; Skin allograft; Transplantation

Indexed keywords

COLCHICINE; COLCHICINE DERIVATIVE; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; TACROLIMUS; TUMOR NECROSIS FACTOR ALPHA;

EID: 67649922205     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.054     Document Type: Article
Times cited : (27)

References (41)
  • 3
    • 0002339624 scopus 로고
    • Borel, J. F, Eds, Elsevier Biochemical Press: Amsterdam
    • Borel, J. F. In Cyclosporin A; Borel, J. F., Eds.; Elsevier Biochemical Press: Amsterdam, 1982; pp 5-17.
    • (1982) Cyclosporin A , pp. 5-17
    • Borel, J.F.1
  • 4
  • 37
    • 67649904400 scopus 로고    scopus 로고
    • note
    • Because the parent compound (9b) of these analogues showed non-selective activity for B and T cells, we just performed lymphoproliferation assay on T-lymphocyte-activated cells as a general thing.
  • 38
    • 67649935959 scopus 로고    scopus 로고
    • note
    • 50 value was expressed as greater than the highest exposure concentration. Each dose response curve is composed of a vehicle (DMSO) group and seven treatment groups spanning an exposure range of 0.1-300 μM. Each value in the curve represents the mean of 4-8 wells in a plate. The α-GST and MTT assays were run from one plate as were the GSH/8-isoprostane assays, while the cell proliferation and ATP assays were run from separate plates.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.