Identification of tobacco-derived compounds in human pancreatic juice

Chemical Research in Toxicology

Volumn 15, Issue 5, 2002, Pages 677-685

  Prokopczyk, Bogdan ^a   Hoffmann, Dietrich ^a   Bologna, Matthew ^a   Cunningham, A John ^a   Trushin, Neil ^a   Akerkar, Shobha ^a   Boyiri, Telih ^a   Amin, Shantu ^a   Desai, Dhimant ^a   Colosimo, Stephen ^a   Pittman, Brian ^a   Leder, Gerhard ^b   Ramadani, Marco ^b   Henne Bruns, Doris ^b   Beger, Hans G ^b   El Bayoumy, Karam ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; COTININE; NITROSAMINE; NITROSONORNICOTINE;

ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EXTRACTION; GAS CHROMATOGRAPHY; HAIR ANALYSIS; HUMAN; MASS SPECTROMETRY; PANCREAS CANCER; PANCREAS JUICE; SMOKING HABIT; TOBACCO; URINALYSIS;

CARCINOGENS; COTININE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HAIR; HUMANS; NICOTINE; NITROSAMINES; PANCREATIC JUICE; PANCREATIC NEOPLASMS; SMOKING;

NICOTIANA TABACUM;

EID: 0036093059     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0101088     Document Type: Article

References (52)

1. Cancer statistics, 2000
2. Coffee and cancer of the pancreas
3. Tobacco, alcohol, and coffee and cancer of the pancreas
4. Dietary and nutritional factors and pancreatic cancer: A case-control study based on dietary interviews
5. A collaborative case-control study on nutrient intake and pancreatic cancer within the SEARCH programme
6. Smoking in relation to the death rates of one million men and women
7. The Dorn study of smoking and mortality among U.S. veterans. Report on eight and one-half years of observation
8. Tobacco smoking. IARC monographs on evaluation of the carcinogenic risk of chemicals to humans
9. A case control study of cancer of the pancreas
10. Pancreas cancer, smoking, beverage consumption, and past medical history
11. Lifestyle risk factors for pancreatic cancer in Louisiana: A case-control study
12. Lifetime history of smoking and exocrine carcinoma of the pancreas: A population-based case-control study in the Netherlands
13. Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States?
14. A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States)
15. Cigarette smoking and pancreas cancer: A case-control study based on direct interviews
16. Predictors of pancreatic cancer mortality among a large cohort of United States adults
17. Cigarette smoking and pancreas cancer: A case-control study based on direct interviews
18. Coffee, alcohol, smoking, and cancer of the pancreas: A case-control study
19. Smoking and pancreatic cancer in men and women
20. The changing cigarette 1950-1995
21. The less harmful cigarette: A controversial issue. A tribute to Ernst L. Wynder
22. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Invited review
23. Tobacco-specific N-nitrosamines and Areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity relevance to humans
24. A study of tobacco carcinogenesis. LIII: Carcinogenicity of N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mink (Mustala vison)
25. A study of betel quid carcinogenesis IX. (1991) Comparative carcinogenicity of 3-(methylnitrosamino)propionitrile (MNPN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) upon local application to mouse skin and rat oral mucosa
26. Tumorigenic activity of tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol (iso-NNAL) and N′-nitrosonornicotine (NNN) on topical application to Sencar mice
27. A study of tobacco carcinogenesis XLII. Induction of lung and pancreas tumors in F344 rats by tobacco-specific and areca-derived N-nitrosamines
28. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone and the effect of diet
29. A study of tobacco carcinogenesis: Effect of the fat content of the diet on the carcinogenic activity of NNK in F344 rats
30. Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen
31. Studies on non-volatile nitrosamines in tobacco
32. Synthesis of carbon-14-labelled myosmine, nornicotine and N′-nitrosonornicotine
33. Preparation of deuterium-labeled guvacine and isoguvacine
34. Analysis for nicotine and cotinine in hair to determine cigarette smoking status
35. Gas chromatographic analysis of nicotine and cotinine in hair
36. Improved methodology for the quantitative assessment of tobacco-specific N-nitrosamines in tobacco by supercritical fluid extraction
37. Identification of tobacco-specific carcinogen in the cervical mucus of smokers and nonsmokers
38. Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine
39. Cigarette smoking and neoplasia of the uterine cervix: Smoke constituents in cervical mucus
40. Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers, and nonsmokers
41. Metabolic activation and detoxification of tobacco-specific nitrosamines - A model for cancer prevention strategies
42. Recent studies on bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen
43. A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke
44. Metabolism of a glucuronide of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
45. Lysosomal enzymes in pure pancreatic juice from normal healthy volunteers and chronic alcoholics
46. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochrome P450, lipoxygenase, and hydroperoxidase
47. Prevention of NNK-induced lung tumorigenesis in A/J mice by salicylic acid and NS-358
48. Human cervical tissue metabolizes the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-py-ridyl)-1-butanone via α-hydroxylation and carbonyl reduction pathways
49. Increased 8-hydroxydeoxyguanosine in DNA of mice and rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
50. Elevated 6-hydroxy-2′-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate