4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue

Cancer Epidemiology Biomarkers and Prevention

Volumn 14, Issue 2, 2005, Pages 540-541

  Prokopczyk, Bogdan ^a,c   Leder, Gerhard ^b   Trushin, Neil ^a,c   Cunningham, A John ^b,c   Akerkar, Shobha ^b,c   Pittman, Brian ^b,c   Ramadani, Marco ^b   Straeter, Joern ^b   Beger, Hans G ^b   Henne Bruns, Doris ^b   El Bayoumy, Karam ^a,c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ULM   (Germany)

^c Div of Cancer Etiology and Prev   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTANONE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; 4 HYDROXY 1 (3 PYRIDYL) 1 BUTANONE; 8 HYDROXYDEOXYGUANOSINE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DNA ISOLATION; HUMAN; HUMAN TISSUE; PANCREAS; PANCREAS CANCER; PANCREAS JUICE; PRIORITY JOURNAL;

BUTANONES; DNA ADDUCTS; DNA DAMAGE; HUMANS; NITROSAMINES; PANCREAS; PANCREATIC NEOPLASMS; PYRIDINES; SMOKING;

EID: 20944432256     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-04-0626     Document Type: Article

References (8)

1. Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 1999;91:1194-210.
2. Rivenson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS. A study of tobacco carcinogenesis XLII. Induction of lung and pancreas tumors in F344 rats by tobacco-specific and areca-derived N-nitrosamines. Cancer Res 1988;48:6912-7.
3. Prokopczyk B, Hoffmann D, Bologna M, et al. Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol 2002;15:677-85.
4. Prokopczyk B, Trushin N, Hoffmann D, et al. 4-(Methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) and human pancreatic cancer: model studies. 93rd Annual Meeting, AACR; 2002. p. 3415.
5. 2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone and 4- (acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with DNA. Chem Res Toxicol 2004;17:588-97.
6. Rosa JG, Prokopczyk B, Desai DH, Amin SG, El-Bayoumy K. Elevated 8-hydroxy-2′-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methy1nitrosamino)-1-(3-pyridy1)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate. Carcinogenesis 1998;19:1783-8.
7. Kutzer C, Branner B, Zwickenpflug W, Richter E. Simultaneous solid-phase extraction and gas chromatography-mass spectrometric determination of hemoglobin adducts from tobacco-specific nitrosamines and aromatic amines. J Chromatogr Sci 1997;35:1-6.
8. Kadlubar FF, Anderson KE, Haussermann S, et al. Comparison of DNA adduct levels associated with oxidative stress in human pancreas. Mutat Res 1998;405:125-33.