Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery

Cardiovascular Research

Volumn 57, Issue 3, 2003, Pages 824-833

  Huang, Yu ^a   Chan, Franky Leung ^a   Lau, Chi Wai ^a   Tsang, Suk Ying ^a   Chen, Zhen Yu ^a   He, Guo Wei ^a   Yao, Xiaoqiang ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Arteries; K channel; Signal transduction; Vasoconstriction dilation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; APAMIN; BARIUM CHLORIDE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; FORSKOLIN; GLIBENCLAMIDE; IBERIOTOXIN; KT 5720; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; TETRYLAMMONIUM; TRIETHYLAMINE; UROCORTIN; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; VASODILATOR AGENT;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; ATTENUATION; CONTROLLED STUDY; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DILATATION; CORONARY ARTERY PRESSURE; FORCE TRANSDUCER; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MYOGRAPHY; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT; ANIMAL; CORONARY BLOOD VESSEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; CORONARY VESSELS; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION; VASODILATOR AGENTS;

EID: 0037370141     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00773-3     Document Type: Article

References (30)

1. Vaughan J., Donaldson C., Bittencourt J., et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 378:1995;287-292.
2. Donaldson C.J., Sutton S.W., Perrin M.H., et al. Cloning and characterization of human urocortin. Endocrinology. 137:1996;2167-2170.
3. Zhao L., Donaldson C.J., Smith G.W., Vale W.W. The structures of the mouse and human urocortin genes (Ucn and UCN). Genomics. 50:1998;23-33.
4. Dautzenberg F.M., Kilpatrick G.J., Hauger R.L., Moreau J. Molecular biology of the CRH receptors - in the mood. Peptides. 22:2001;753-760.
5. Lovenberg T.W., Chalmers D.T., Liu C., De Souza E.B. CRF2α and CRF2β receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology. 136:1995;4139-4142.
6. Perrin M., Donaldson C., Chen R., Blount A., Berggren T., Bilezikjian L., Sawchenko P., Vale W. Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci USA. 92:1995;2969-2973.
7. Chen R., Lewis K.A., Perrin M.H., Vale W.W. Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci USA. 90:1993;8967-8971.
8. Stenzel P., Kesterson R., Yeung W., Cone R.D., Rittenberg M.B., Stenzel-Poore M.P. Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol Endocrinol. 9:1995;637-645.
9. Dautzenberg F.M., Hauger R.L. The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol Sci. 23:2000;71-77.
10. Rossant C.J., Pinnock R.D., Hughes J., Hall M.D., McNulty S. Corticotropin-releasing factor type 1 and type 2alpha receptors regulate phosphorylation of calcium/cyclic adenosine 3′,5′-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase. Endocrinology. 140:1999;1525-1536.
11. Parkes D.G., Vaughan J., Rivier J., Vale W., May C.N. Cardiac inotropic actions of urocortin in conscious sheep. Am J Physiol. 272:1997;H2115-H2122.
12. Terui K., Higashiyama A., Horiba N., Furukawa K.I., Motomura S., Suda T. Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart. J. Endocrinol. 169:2001;177-183.
13. Heldwein K.A., Redick D.L., Rittenberg M.B., Claycomb W.C., Stenzel-Poore M.P. Corticotropin-releasing hormone receptor expression and functional coupling in neonatal cardiac myocytes and AT-1 cells. Endocrinology. 137:1996;3631-3639.
14. Parkes D.G., Weisinger R.S., May C.N. Cardiovascular actions of CRH and urocortin: an update. Peptides. 22:2001;821-827.
15. Coste S.C., Kesterson R.A., Heldwein K.A., et al. Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet. 24:2000;403-409.
16. Brar B.K., Stephanou A., Okosi A., et al. CRH-like peptides protect cardiac myocytes from lethal ischaemic injury. Mol Cell Endocrinol. 158:1999;55-63.
17. Brar B.K., Jonassen A.K., Stephanou A., et al. Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. J Biol Chem. 275:2000;8508-8514.
18. Leitch I.M., Boura A.L., Botti C., et al. Vasodilator actimons of urocortin and related peptides in the human perfused placenta in vitro. J Clin Endocrinol Metab. 83:1998;4510-4513.
19. Schilling L., Kanzler C., Schmiedek P., Ehrenreich H. Characterization of the relaxant action of urocortin, a new peptide related to corticotropin-releasing factor in the rat isolated basilar artery. Br J Pharmacol. 125:1998;1164-1171.
20. + channels. Br J Pharmacol. 135:2002;1467-1476.
21. Lubomirov L., Gagov H., Petkova-Kirova P., et al. Urocortin relaxes rat tail arteries by a PKA-mediated reduction of the sensitivity of the contractile apparatus for calcium. Br J Pharmacol. 134:2001;1564-1570.
22. Langton P.D., Nelson M.T., Huang Y., Standen N.B. Block of calcium-activated potassium channels in mammalian arterial myocytes by tetraethylammonium ions. Am J Physiol. 260:1991;H927-H934.
23. Sanz E., Monge L., Fernandez N., et al. Relaxation by urocortin of human saphenous veins. Br J Pharmacol. 136:2002;90-94.
24. + channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle. J Physiol. 507:1998;117-129.
25. + channels by β agonist in rabbit coronary smooth muscle cells. Yonsei Med J. 36:1995;232-242.
26. + channels in arterial smooth muscle. Science. 245:1989;177-180.
27. + currents. J Muscle Res Cell Motil. 21:2000;639-645.
28. 2+. Am J Physiol. 271:1996;H696-H705.
29. 2 receptor-mediated tonic contraction is attributed to an activation of phosphatidylcholine-specific phospholipase C in rabbit aortic smooth muscle. Life Sci. 66:1999;PL71-76.
30. Watanabe F., Oki Y., Ozawa M., et al. Urocortin in human placenta and maternal plasma. Peptides. 20:1999;205-209.