Parathyroid hormone signaling in bone and kidney

Current Opinion in Nephrology and Hypertension

Volumn 18, Issue 4, 2009, Pages 298-302

  Lee, Minnkyong ^a   Partridge, Nicola C ^a,b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Parathyroid hormone; parathyroid hormone type 1 receptor; protein kinase A; protein kinase C; sodium hydrogen exchanger regulatory factor 1

Indexed keywords

PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1; SCLEROSTIN; SECRETED FRIZZLED RELATED PROTEIN 4; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR 1; SODIUM PHOSPHATE COTRANSPORTER 2A; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT4 PROTEIN;

APICAL MEMBRANE; BONE; BONE METABOLISM; HUMAN; KIDNEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BONE AND BONES; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; KIDNEY; PARATHYROID HORMONE; PHOSPHOPROTEINS; PROTEIN KINASE C; RECEPTOR, PARATHYROID HORMONE, TYPE 1; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 67649802514     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32832c2264     Document Type: Review

References (58)

1. Juppner H, Abou-Samra AB, Freeman M, et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991; 254:1024-1026.
2. Abou-Samra AB, Juppner H, Force T, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 1992; 89:2732-2736.
3. van Abel M, Hoenderop JG, van der Kemp AW, et al. Coordinated control of renal Ca(2+) transport proteins by parathyroid hormone. Kidney Int 2005; 68:1708-1721.
4. Cha SK, Wu T, Huang CL. Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. Am J Physiol Renal Physiol 2008; 294:F1212-F1221. This study suggests that PTH regulation of TRPV5 activity is mediated through PKC-dependent pathways.
5. Swarthout JT, Doggett TA, Lemker JL, Partridge NC. Stimulation of extra- cellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent. J Biol Chem 2001; 276:7586-7592.
6. Wang B, Yang Y, Friedman PA. Na/H exchange regulatory factor 1, a novel AKT-associating protein, regulates extracellular signal-regulated kinase signaling through a B-Raf-mediated pathway. Mol Biol Cell 2008; 19:1637-1645.
7. Lee K, Brown D, Urena P, et al. Localization of parathyroid hormone/parathyroid hormone-related peptide receptor mRNA in kidney. Am J Physiol 1996; 270:F186-F191.
8. Yang T, Hassan S, Huang YG, et al. Expression of PTHrP, PTH/PTHrP receptor, and Ca(2+)-sensing receptor mRNAs along the rat nephron. Am J Physiol 1997; 272:F751-F758.
9. Rubin DA, Juppner H. Zebrafish express the common parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) and a novel receptor (PTH3R) that is preferentially activated by mammalian and fugufish parathyroid hormone-related peptide. J Biol Chem 1999; 274:28185-28190.
10. Usdin TB, Gruber C, Bonner TI. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem 1995; 270:15455-15458.
11. Jouishomme H, Whitfield JF, Gagnon L, et al. Further definition of the protein kinase C activation domain of the parathyroid hormone. J Bone Miner Res 1994; 9:943-949.
12. Lee C, Luck MD, Juppner H, et al. Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop. Mol Endocrinol 1995; 9:1269-1278.
13. Shimizu M, Potts JT Jr, Gardella TJ. Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptor. J Biol Chem 2000; 275:21836-21843.
14. Gardella TJ, Wilson AK, Keutmann HT, et al. Analysis of parathyroid hormone's principal receptor-binding region by site-directed mutagenesis and analog design. Endocrinology 1993; 132:2024-2030.
15. Tawfeek HA, Qian F, Abou-Samra AB. Phosphorylation of the receptor for PTH and PTHrP is required for internalization and regulates receptor signaling. Mol Endocrinol 2002; 16:1-13.
16. Miedlich SU, Abou-Samra AB. Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization. Am J Physiol Endocrinol Metab 2008; 295:E665-E671.
17. Ono N, Nakashima K, Rittling SR, et al. Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts. J Biol Chem 2008; 283:19400-19409.
18. Gonzalez EA, Martin KJ. Coordinate regulation of PTH/PTHrP receptors by PTH and calcitriol in UMR 106-01 osteoblast-like cells. Kidney Int 1996; 50:63-70.
19. Li X, Liu H, Qin L, et al. Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem 2007; 282:33086-33097.
20. Wheeler D, Garrido JL, Bisello A, et al. Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells. Mol Endocrinol 2008; 22:1163-1170.
21. Wang B, Yang Y, Abou-Samra A, Friedman P. NHERF1 regulates parathyroid hormone receptor desensitization: interference with {beta}-arrestin binding. Mol Pharmacol 2009. [Epub ahead of print]. The results here suggest a mechanism for NHERF1 regulation of PTH1R desensitization and subsequent internalization.
22. Yang D, Singh R, Divieti P, et al. Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone 2007; 40:1453-1461.
23. Yu S, Franceschi RT, Luo M, et al. Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology 2008; 149:1960-1968. Regulation of ATF4 by PTH is mainly mediated through PKA.
24. Fritsch J, Chesnoy-Marchais D. Dual modulation of the L-type calcium current of rat osteoblastic cells by parathyroid hormone: opposite effects of protein kinase C and cyclic nucleotides. Cell Signal 1994; 6:645-655.
25. Lee SK, Lorenzo JA. Regulation of receptor activator of nuclear factor-kappa B ligand and osteoprotegerin mRNA expression by parathyroid hormone is predominantly mediated by the protein kinase a pathway in murine bone marrow culture. Bone 2002; 31:252-259.
26. Raggatt LJ, Qin L, Tamasi J, et al. Interleukin-18 is regulated by parathyroid hormone and is required for its bone anabolic actions. J Biol Chem 2008; 283:6790-6798. Studies using mice lacking IL-18 demonstrate a role for IL-18 in the anabolic actions of PTH in bone.
27. Li X, Qin L, Bergenstock M, et al. Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts. J Biol Chem 2007; 282:33098-33106.
28. Kim MS, Day CJ, Morrison NA. MCP-1 is induced by receptor activator of nuclear factor-kB ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. J Biol Chem 2005; 280:16163-16169.
29. Horwood NJ, Udagawa N, Elliott J, et al. Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor. J Clin Invest 1998; 101:595-603.
30. Swarthout JT, Tyson DR, Jefcoat SC Jr, Partridge NC. Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells. J Bone Miner Res 2002; 17:1401-1407.
31. Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem 2002; 277:48868-48875.
32. Hinoi E, Ueshima T, Hojo H, et al. Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes. J Biol Chem 2006; 281:23632-23642.
33. Qin L, Qiu P, Wang L, et al. Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics. J Biol Chem 2003; 278:19723-19731.
34. Liu F, Lee SK, Adams DJ, et al. CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment. Bone 2007; 40:1135-1143.
35. Krishnan V, Moore TL, Ma YL, et al. Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling. Mol Endocrinol 2003; 17:423-435.
36. Selvamurugan N, Shimizu E, Lee M, et al. Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation. FEBS Lett 2009; 583:1141-1146.
37. Bellido T, Ali AA, Plotkin LI, et al. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced antiapoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 2003; 278:50259-50272.
38. O'Brien CA, Plotkin LI, Galli C, et al. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS ONE 2008; 3:e2942. This study demonstrates the regulation of Wnt signaling by PTH in osteocytes in both LRP5-dependent and independent pathways.
39. Pederson L, Ruan M, Westendorf JJ, et al. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1- phosphate. Proc Natl Acad Sci USA 2008; 105:20764-20769.
40. Bergenstock MK, Partridge NC. Parathyroid hormone stimulation of non-canonical Wnt signaling in bone. Ann N Y Acad Sci 2007; 1116:354-359.
41. Wan M, Yang C, Li J, et al. Parathyroid hormone signaling through low-density lipoprotein-related protein 6. Genes Dev 2008; 22:2968-2979.
42. Brenza HL, Kimmel-Jehan C, Jehan F, et al. Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Proc Natl Acad Sci USA 1998; 95:1387-1391.
43. Custer M, Lotscher M, Biber J, et al. Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry. Am J Physiol 1994; 266:F767-F774.
44. Bacic D, Lehir M, Biber J, et al. The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Kidney Int 2006; 69:495-503.
45. Segawa H, Yamanaka S, Onitsuka A, et al. Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter. Am J Physiol Renal Physiol 2007; 292:F395-F403.
46. Traebert M, Volkl H, Biber J, et al. Luminal and contraluminal action of 1-34 and 3-34 PTH peptides on renal type IIa Na-P(i) cotransporter. Am J Physiol Renal Physiol 2000; 278:F792-F798.
47. Bacic D, Schulz N, Biber J, et al. Involvement of the MAPK-kinase pathway in the PTH-mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney. Pflugers Arch 2003; 446:52-60.
48. Cunningham R, Biswas R, Brazie M, et al. Signaling pathways utilized by PTH and dopamine to inhibit phosphate transport in mouse renal proximal tubule cells. Am J Physiol Renal Physiol 2009; 296:F355-F361.
49. Gisler SM, Stagljar I, Traebert M, et al. Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem 2001; 276:9206-9213.
50. Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature 2002; 417:858-861.
51. Deliot N, Hernando N, Horst-Liu Z, et al. Parathyroid hormone treatment induces dissociation of type IIa Na+-P(i) cotransporter-Na+/H+ exchanger regulatory factor-1 complexes. Am J Physiol Cell Physiol 2005; 289:C159-C167.
52. Weinman EJ, Biswas RS, Peng G, et al. Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J Clin Invest 2007; 117:3412-3420.
53. Tang Y, Tang J, Chen Z, et al. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. J Biol Chem 2000; 275:37559-37564.
54. Capuano P, Bacic D, Roos M, et al. Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. Am J Physiol Cell Physiol 2007; 292:C927-C934.
55. Karim Z, Gerard B, Bakouh N, et al. NHERF1 mutations and responsiveness of renal parathyroid hormone. N Engl J Med 2008; 359:1128-1135. NHERF1 mutations identified in patients with diminished renal phosphate reuptake capacity, yet normal serum PTH levels, suggest a role for NHERF1 downstream of PTH signaling.
56. Guyton AC, Hall JE. Textbook of medical physiology. Philadelphia: Elsevier Saunders; 2006. vol. XXXV. p. 1116.
57. Lambers TT, Bindels RJ, Hoenderop JG. Coordinated control of renal Ca2+ handling. Kidney Int 2006; 69:650-654.
58. Topala CN, Schoeber JP, Searchfield LE, et al. Activation of the Ca(2+)- sensing receptor stimulates the activity of the epithelial Ca(2+) channel TRPV5. Cell Calcium 2009; 45:331-339.