Optimization of Energy-Consuming Pathways towards Rapid Growth in HPV-Transformed Cells

PLoS ONE

Volumn 2, Issue 7, 2007, Pages

  Mizrachy Schwartz, Sarit ^a   Kravchenko Balasha, Nataly ^a   Ben Bassat, Hannah ^b   Klein, Shoshana ^a   Levitzki, Alexander ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; BENZO[A]PYRENE; CARCINOGEN; METHYLENE BLUE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE C SRC; PROTEIN-TYROSINE KINASE C-SRC;

ARTICLE; CELL DIVISION; CELL SIZE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; METABOLISM; NEOPLASM; OXYGEN CONSUMPTION; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ADENYLATE KINASE; BENZO(A)PYRENE; CARCINOGENS; CELL DIVISION; CELL SIZE; ENZYME ACTIVATION; HUMAN PAPILLOMAVIRUS 16; HUMANS; KERATINOCYTES; METHYLENE BLUE; NEOPLASMS; OXYGEN CONSUMPTION; PROTEIN-TYROSINE KINASES;

EID: 67649697143     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000628     Document Type: Article

References (29)

1. Vogelstein B, Kinzler KW, (2004) Cancer genes and the pathways they control. Nat Med 10: 789-799.
2. Warburg O, (1956) On respiratory impairment in cancer cells. Science 124: 269-270.
3. Gatenby RA, Gillies RJ, (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899.
4. Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV, (2002) The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 55: 244-265.
5. Mitrani-Rosenbaum S, Tsvieli R, (1992) Differential cooperation of a carcinogen with human papillomavirus type 6 and 16 DNAs in in vitro oncogenic transformation. Intervirology 33: 76-85.
6. Santin AD, Zhan F, Bignotti E, Siegel ER, Cane S, et al.(2005) Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virology 331: 269-291.
7. Vermes I, Haanen C, Reutelingsperger C, (2000) Flow cytometry of apoptotic cell death. J Immunol Methods 243: 167-190.
8. Inoki K, Zhu T, Guan KL, (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590.
9. Stoneley M, Paulin FE, Le Quesne JP, Chappell SA, Willis AE, (1998) C-Myc 5′ untranslated region contains an internal ribosome entry segment. Oncogene 16: 423-428.
10. Holcik M, Graber T, Lewis SM, Lefebvre CA, Lacasse E, et al.(2005) Spurious splicing within the XIAP 5′ UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system. Rna 11: 1605-1609.
11. Akiri G, Nahari D, Finkelstein Y, Le SY, Elroy-Stein O, et al.(1998) Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription. Oncogene 17: 227-236.
12. Lang KJ, Kappel A, Goodall GJ, (2002) Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 13: 1792-1801.
13. Svitkin YV, Herdy B, Costa-Mattioli M, Gingras AC, Raught B, et al.(2005) Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol 25: 10556-10565.
14. Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R, (2004) Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 24: 6539-6549.
15. Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, et al.(2005) Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 280: 32081-32089.
16. Kato K, Ogura T, Kishimoto A, Minegishi Y, Nakajima N, et al.(2002) Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation. Oncogene 21: 6082-6090.
17. Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WGt, et al.(2004) Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 279: 43940-43951.
18. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, et al.(1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271: 695-701.
19. Kim EK, Miller I, Aja S, Landree LE, Pinn M, et al.(2004) C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 279: 19970-19976.
20. Holcik M, (2004) Targeting translation for treatment of cancer-a novel role for IRES? Curr Cancer Drug Targets 4: 299-311.
21. Otto GA, Puglisi JD, (2004) The pathway of HCV IRES-mediated translation initiation. Cell 119: 369-380.
22. Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, et al.(2001) Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science 291: 1959-1962.
23. Holcik M, Sonenberg N, (2005) Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 6: 318-327.
24. Storchova Z, Pellman D, (2004) From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 5: 45-54.
25. Mountford PS, Smith AG, (1995) Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis. Trends Genet 11: 179-184.
26. Pestova TV, Shatsky IN, Fletcher SP, Jackson RJ, Hellen CU, (1998) A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs. Genes Dev 12: 67-83.
27. Gebauer F, Hentze MW, (2004) Molecular mechanisms of translational control. Nat Rev Mol Cell Biol 5: 827-835.
28. Sabatini DM, (2006) mTOR and cancer: insights into a complex relationship. Nat Rev Cancer 6: 729-734.
29. Carrera AC, (2004) TOR signaling in mammals. J Cell Sci 117: 4615-4616.