Interleukin-6 (IL-6) inhibits thyroid function in the presence of soluble IL-6 receptor in cultured human thyroid follicles

Endocrinology

Volumn 137, Issue 11, 1996, Pages 4857-4863

  Yamazaki, Kazuko ^a,d   Yamada, Emiko ^a   Kanaji, Yoshio ^a   Shizume, Kazuo ^b   Wang, Da Shen ^b   Maruo, Naoko ^c   Obara, Takao ^d   Sato, Kanji ^d  

^a Kanaji Hospital   (Japan)

^b Foundation for Growth Science   (Japan)

^c TOSOH CORPORATION   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

ARTICLE; DOSE RESPONSE; GRAVES DISEASE; HORMONE DETERMINATION; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THYROID FOLLICLE; THYROID FUNCTION;

EID: 0029845853     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.11.8895357     Document Type: Article

References (45)

1. Doctor R, Krenning EP, De Jong M, Henneman G 1993 The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol (Oxf) 39:499-518
2. Jones TH 1994 Interleukin-6 an endocrine cytokine. Clin Endocrinol (Oxf) 40:703-713
3. Ozawa M, Sato K, Han D, Kawakami M, Tsushima T, Shizume K 1988 Effects of tumor necrosis factor-α/cachectin on thyroid hormone metabolism in mice. Endocrinology 123:1461-1467
4. Fujii T, Sato K, Ozawa M, Kasono K, Imamura H, Kanaji Y, Tsushima T, Shizume K 1989 Effects of interleukin 1 on thyroid hormone metabolism in mice: stimulation by IL-1 of type 1 iodothyronine-5′-deiodinase in the liver. Endocrinology 124:167-173
5. Pang XP, Hershman JM, Mirell CJ, Pekary AE 1989 Impairment of hypothalamic- pituitary-thyroid function in rats treated with human recombinant tumor necrosis factor-α (cachectin). Endocrinology 125:76-84
6. 125I organisation and thyroid hormone release by interleukin-1, tumor necrosis factor-α, and interferon-γ in human thyrocytes in suspension culture. J Clin Endocrinol Metab 70:1735-1743
7. Van der Pole T, Romjin JA, Wiersinga WM, Sauerwein HP 1990 Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. J Clin Endocrinol Metab 71:1567-1572
8. 125I incorporation and thyroid hormone release by human thyroid follicles in vitro. J Clin Endocrinol Metab 77:1439-1441
9. Boelen A, Platvoet-Ter Shiphorst MC, Wiersinga WM 1993 Association between serum interleukin-6 and serum 3,5,3′-triiodothyronine in nonthyroidal illness. J Clin Endocrinol Metab 77:1695-1699
10. Hashimoto H, Igarashi N, Yachie A, Miyawaki T, Sato T1994 The relationship between serum levels of interleukin-6 and thyroid hormone in children with acute respiratory infection. J Clin Endocrinol Metab 78:288-291
11. Bartalena L, Brogioni S, Grasso L, Velluzzi F, Martino E 1994 Relationship of the increased interleukin-6 concentration to changes of thyroid function in nonthyroidal illness. J Endocrinol Invest 17:269-274
12. Van Haasteren GAC, van der Meer MJM, Hermus ARMM, Linkels E, Klootwijk W, Kaptein E, van Toor H, Sweep CGJ, Visser TJ, de Greep WJ 1994 Different effects of continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis. Endocrinology 135:1336-1345
13. Hashimoto H, Igarashi N, Yachie A, Miyawaki T, Hashimoto T, Sato T 1996 The relationship between serum levels of interleukin-6 and thyroid hormone during the follow-up study in children with nonthyroidal illness: marked inverse correlation in Kawasaki and infectious disease. Endocrine J 43:31-38
14. Davies PH, Black EG, Sheppard MC, Franklyn JA 1996 Relation between serum interleukin-6 and thyroid hormone concentrations in 270 hospital in-patients with nonthyroidal illness. Clin Endocrinol (Oxf) 44:199-205
15. Tominaga T, Yamashita S, Nagayama Y, Morita S, Yokoyama N, Izumi M, Nagataki S 1991 Interleukin-6 inhibits human thyroid peroxidase gene expression. Acta Endocrinol (Copenh) 124:290-294
16. Weetman AP, Bright-Thomas R, Freeman M 1990 Regulation of interleukin-6 release by human thyrocytes. J Endocrinol 127:357-361
17. Rasmussen AK, Kayser L, Bech K, Feld-Rasmussen U, Perrild H, Bendtzen K 1991 Influence of interleukin-6 on the function of secondary cultures of human thyrocytes. Acta Endocrinol (Copenh) 124:577-582
18. Sato K, Yamazaki K, Shizume K, Yamakawa Y, Satoh T, Demura H, Kanaji Jr Y, Obara T, Fujimoto Y, Aiba M, Kakiuchi T, Kanaji Y 1993 Pathogenesis of autoimmune hypothyroidism induced by lymphokine-activated killer (LAK) cell therapy: in vitro inhibition of human thyroid function by interleukin-2 in the presence of autologous intrathyroidal lymphocytes. Thyroid 3:179-188
19. Stouthard JML, van der Poll T, Endert E, Bakker PJM, Veenhof CHN, Sauerwein HP, Romjin JA 1994 Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans. J Clin Endocrinol Metab 79:1342-1346
20. Kishimoto T, Taga T, Akira S 1994 Cytokine signal transduction. Cell 76:253-262
21. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T 1990 Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell 63:1149-1157
22. 125I incorporation and de novo synthesized thyroid hormone release in human thyroid follicles. J Clin Endocrinol Metab 80:473-479
23. Sato K, Yamazaki K, Shizume K, Kanaji Y, Obara T, Ohsumi K, Demura H, Yamaguchi S, Shibuya M 1995 Stimulation by TSH and Graves' IgG of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and fit mRNA expression in the rat thyroid in vivo. J Clin Invest 96:1295-1302
24. Sato K, Robbins J 1981 Thyroid hormone metabolism in primary cultured rat hepatocytes. Effects of glucose, glucagon, and insulin. J Clin Invest 68:475-483
25. Chomczynski P, Sacchi N 1987 Single step method of RNA isolation by acid guanidinium isocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
26. Inoue K, Sugiyama H, Ogawa J, Yamagami T, Azuma T, Oka Y, Miwa H, Kita K, Hiraoka A, Masaoka T, Nasu K, Kyo T, Dohy H, Hara J, Kanamaru A, Kishimoto T 1994 Expression of the interleukin-6 (IL-6), IL-6 receptor and gp130 genes in acute leukemia. Blood 84:2672-2680
27. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T 1986 Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324:73-76
28. Yamasaki K, Taga T, Hirata Y, Yawata H, Kawanishi Y, Seed B, Taniguchi T, Hirano T, Kishimoto T 1988 Cloning and expression of the human interleukin-6 (BSF-2/IFN-b2) receptor. Science 241:825-828
29. Nakajima-Iijima S, Hamada H, Reddy P, Kakunaga T 1985 Molecular structure of the human cytoplasmic β-actin gene: interspecies homology of sequences in the introns. Proc Natl Acad Sci USA 82:6133-6137
30. Shintani F, Kanba S, Maruo N 1991 Serum interleukin-6 in schizophrenic patients. Life Sci 49:661-664
31. Gaillard JP, Bataille R, Brailly H, Zuber C, Yasukawa K, Attal M, Maruo N, Taga T, Kishimoto T, Klein B 1993 Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy. Eur J Immunol 23:820-824
32. Zheng RQH, Abney E, Chu CQ, Field M, Grubeck-Loebenstein B, Main RN, Feldman M 1991 Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by nonradioactive in situ hybridization and immunohistochemical methods. Clin Exp Immunol 83:314-319
33. Grubeck-Lobenstein B, Buchan G, Chantry D, Kassal H, Londei M, Pirich K, Barrett K, Turner M, Waldhausl W, Feldman M 1989 Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1α and interleukin-6. Clin Exp Immunol 77:324-330
34. Diamant M, Kayser L, Rasmussen AH, Bech K, Feldt-Rasmussen U 1991 Interleukin-6 production by thyroid epithelial cells. Enhancement by interleukin-1. Autoimmunity 11:21-26
35. Watson PF, Pickerill AP, Davies R, Weetman AP 1995 Semiquantitative analysis of interleukin-1α, interleukin-6 and interleukin-8 mRNA expression by human thyrocytes. J Mol Endocrinol 15:11-21
36. Van Snick J 1990 Interleukin-6: an overview. Annu Rev Immunol 8:253-278
37. Martin A, Goldsmith NK, Friedman EW, Schwartz AE, Davies TF, Roman SH 1990 Intrathyroidal accumulation of T cell phenotypes in autoimmune thyroid disease. Autoimmunity 6:269-281
38. Nakajima T, Yamamoto S, Cheng M, Yasukawa K, Hirano T, Kishimoto T, Tokunaga T, Honda M 1992 Soluble interleukin-6 receptor is released from receptor-bearing cell lines in vitro. Jpn J Cancer Res 83:373-378
39. Mackiewicz A, Schooltink H, Heinrich PC, Rose-John S 1992 Complex of soluble IL-6 receptor/IL-6 up-regulates expression of acute-phase protein. Proc Natl Acad Sci USA 149:2021-2027
40. Matsuzaki N, Neki R, Sawai K, Shimoya K, Okada T, Sakata M, Saji F, Koishihara Y, Ida N 1995 Soluble interleukin-6 (IL-6) receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer. J Clin Endocrinol Metab 80:2912-2917
41. Saito M, Yoshida K, Hibi M, Taga T, Kishimoto T 1992 Molecular cloning of a murine receptor-associated signal transducer, gp130, and its regulated expression in vivo. Proc Natl Acad Sci USA 148:4066-4071
42. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Koshihara Y, Ohsugi Y, Kumaki K, Taga T, Kishimoto T, Suda T 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc Natl Acad Sci USA 90:11924-11928
43. Boelen A, Schiphorst MCP, Wiersinga WM 1995 Soluble cytokine receptors and the low 3,5,3′-triiodothyronine syndrome in patients with nonthyroidal disease. J Clin Endocrinol Metab 80:971-976
44. De Benedetti F, Massa M, Pignatti P, Albani S, Novick D, Martini A 1994 Serum soluble interleukin-6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest 93:2114-2119
45. Castell JV, Klapproth J, Gross V, Walter E, Andus T, Snyers L, Content J, Heinrich P 1990 Fate of interleukin-6 in the rat. Involvement of skin in its catabolism. Eur J Biochem 189:113-118