Lack of increased serum interleukin-6 and soluble IL-6 receptor concentrations in patients with thyroid diseases following recombinant human interferon alpha; therapy

Journal of Investigative Medicine

Volumn 44, Issue 6, 1996, Pages 370-374

  Minelli, Roberta ^b   Girasole, Giuseppe ^b   Pedrazzoni, Mario ^b   Giuliani, Nicola ^b   Schianchi, Claudia ^b   Giuberti, Tiziana ^b   Braverman, Lewis E ^a,b   Salvi, Mario ^b   Roti, Elio ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Department of Medicine ^*

Author keywords

IL 6; rIFN ; sIL 6R; Thyroiditis

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN RECEPTOR; LEUKOCYTE ANTIGEN; RECOMBINANT PROTEIN;

ARTICLE; BLOOD; CHRONIC HEPATITIS; FEMALE; HUMAN; HYPERTHYROIDISM; MALE; THYROID DISEASE; THYROTOXICOSIS;

ANTIGENS, CD; FEMALE; HEPATITIS, CHRONIC; HUMANS; HYPERTHYROIDISM; INTERFERON-ALPHA; INTERLEUKIN-6; MALE; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS; THYROID DISEASES; THYROTOXICOSIS;

EID: 0030209867     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bartalena L, Brogioni S, Grasso L, Martine E. Increased serum interleukin-6 concentration in patients with subacute thyroiditis: relationship with concomitant changes in serum T4-binding globulin concentration. J Endocrinol Invest 1993; 16:213-8.
2. Bartalena L, Grasso L, Brogioni S, Aghini-Lombardi F, Braverman LE, Martino E. Serum interleukin-6 in amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab 1994; 78:423-7.
3. Bartalena L, Brogioni S, Grasso L, Rago T, Vitti P, Pinchera A, Martino E. Interleukin-6: a marker of thyroid destructive processes? J Clin Endocrinol Metab 1994; 79:1424-7.
4. Vial T, Descote J. Clinical toxicity of the interferons. Drug Safety 1994; 10:115-50.
5. Marcellin P, Pouteau M, Benhamou JP. Hepatitis C virus infection, alpha interferon therapy and thyroid dysfunction. J Hepatol 1995; 22:364-9.
6. Burnan P, Totterman TH, Oberg K, Karlsson FA. Thyroid autoimmunity in patients on long term therapy with leukocyte-derived interferon. J Clin Endocrinol Metab 1986; 63:1086-90.
7. Lisker-Melman M, DiBisceglie AM, Usala SJ, Weintraub B, Murray LM, Hoofnagle JH. Development of thyroid disease during therapy of chronic viral hepatitis with interferon alpha. Gastroenterology 1992; 102:2155-60.
8. Vassilopulou-Sellin R, Sella A, Dexeus FH, Theriault RL, Pololoff DA. Acute thyroid dysfunction (thyroiditis) after therapy with interleukin-2. Horm Metab Res 1992; 24:434-8.
9. Kamikubo K, Takami R, Suwa T, Kawase Y, Shiroki J, Kametani M, Tokimitsu N, Sakata S. Case report: silent thyroiditis developed during alpha-interferon therapy. Am J Med Sci 1993; 306:174-6.
10. Sauter NP, Atins MB, Mier JW, Lechan RM. Transient thyrotoxicosis and persistent hypothyroidism due to acute autoimmune thyroiditis after interleukin-2 and interferon-alpha therapy for metastatic carcinoma: a case report. Am J Med 1992; 92:441-4.
11. Watanabe U, Hashimoto E, Hisamitsu T, Obata H, Hayashi N. The risk factor for development of thyroid disease during interferon-alpha therapy for chronic hepatitis C. Am J Gastroenterol 1994; 89:399-403.
12. Minelli R, Giuberti T, Schianchi C, Marchelli S, Gardini E, Salvi M, Braverman LE, Roti E. Multiple changes in thyroid status in patients treated with recombinant interferon a (rIFN-α). Am J Med. In press.
13. Celik I, Akalin S, Erbas T. Serum levels of interleukin-6 and tumor necrosis factor-α in hyperthyroid patients before and after propylthiouracil treatment. Eur J Endocrinology 1995; 132:668-72.
14. Weetman AP, Bright-Thomas R, Freeman M. Regulation of interleukin-6 release by human thyrocytes. J Endocrinol 1990; 127:357-61.
15. Grubeck-Loebenstein B, Buchan G, Chantry D, Kassal H, Londei M, Pirich K, Barret K, Turner M, Waldhausl W, Feldmann M. Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1α and interleukin-6. Clin Exp Immunol 1989; 77:324-30.
16. Zheng RQ, Abney E, Chu CQ, Field M, Grubeck-Loebenstein B, Maini RN, Feldmann M. Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods. Clin Exp Immunol 1991; 83:314-9.
17. Diamant M, Kayser L, Rasmussen AK, Bech K, Feldt-Rasmussen U. Interleukin-6 production by thyroid epithelial cells. Enhancement of interleukin-1. Autoimmunity 1991; 11:21-6.
18. Kennedy RL, Jones TH, Davies R, Justice SK, Lemoine NR. Release of interleukin-6 by human epithelial cells immortalized by simian virus 40 DNA transfection. J Endocrinol 1992; 133:477-82.
19. Gasche C, Reinisch W, Vogelsang H, Potzi R, Markis E, Micksche M, Wirth HP, Gangl A, Lochs H. Prospective evaluation of interferon-alpha in treatment of chronic active Crohn's disease. Dig Dis Sci 1995; 40:800-4.
20. Quiroga JA, Martin J, Pardo M, Carreno V. Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon-alpha. Dig Dis Sci 1994; 39:2485-96.
21. de Wit R, Raasveld MH, ten Berge RJ, van der Wouw PA, Bakker PJ, Veenhof CH. Interleukin-6 concentrations in the serum of patients with AIDS associated Karposi's sarcoma during treatment with interferon-alpha. J Intern Med 1991; 229:539-42.
22. Naredi P, Hafstrom L, Zachrisson H, Rudenstam CM, Lundholm K. Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferonalpha. Eur J Surg 1994; 160:67-75.
23. Zauli G, Re MC, Gugliotta L, Furlini G, LaPlaca M. The elevation of circulating platelets after IFN-alpha therapy in HIV-1 seropositive thrombocytopenic patients correlates with increased plasma levels of IL-6. Microbiologica 1993; 16:27-34.
24. Castell JV, Geiger T, Gross V, Andus T, Walter E, Hirano T, Kishimoto T, Heinrich PC. Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat. Eur J Biochem 1988;177:357-61.
25. Pietzko D, Zohlnhofer D, Graeve L, Fleischer D, Stoyan T, Schooltink H, Rose JS, Heinrich PC. The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone. J Biol Chem 1993;268:4250-8.
26. Kishimoto T, Akira S, Taga T. Interleukin-6 and its receptor: a paradigm for cytokines. Science 1992; 258:593-597.
27. Mackiewicz, Schooltink H, Heinrich PC, Rose-John S. Complex of soluble human IL-6 receptor/IL-6 up-regulates expression of acute phase proteins. J Immunol 1992; 149:2021-7.
28. Salvi M, Girasole G, Pedrazzoni M, Passeri M, Giuliani N, Minelli R, Braverman LE, Roti E. Increased serum concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor in patients with Graves' disease. J Clin Endocrinol Metab. In Press.