Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 14, 2009, Pages 3977-3980

  Jain, Nareshkumar ^a   Allan, George ^a   Linton, Olivia ^a   Tannenbaum, Pamela ^a   Chen, Xin ^a   Xu, Jun ^a   Zhu, Peifang ^a   Gunnet, Joseph ^a   Demarest, Keith ^a   Lundeen, Scott ^a   Murray, William ^a   Sui, Zhihua ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Glucocorticoid receptor (GR) antagonist; Progesterone antagonists; Pseudo steroids; T47D

Indexed keywords

ANTIGESTAGEN; AROMATIC CARBOXYLIC ACID; COMPLEMENT COMPONENT C3; ETHINYLESTRADIOL; FURAN DERIVATIVE; GESTAGEN; GRIGNARD REAGENT; MIFEPRISTONE; PROGESTERONE; PROGESTERONE RECEPTOR; PSEUDOSTEROID DERIVATIVE; SPIROFURANE; TRENBOLONE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEPROTECTION REACTION; DIHYDROXYLATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SWERN OXIDATION;

ADMINISTRATION, ORAL; ANIMALS; BENZOXEPINS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FEMALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP; TRENBOLONE;

RATTUS;

EID: 67649660137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.095     Document Type: Article

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