Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 9, 2007, Pages 2531-2534

  Kang, Fu An ^a   Guan, Jihua ^a   Jain, Nareshkumar ^a   Allan, George ^a   Linton, Olivia ^a   Tannenbaum, Pamela ^a   Chen, Xin ^a   Xu, Jun ^a   Zhu, Peifang ^a   Gunnet, Joseph ^a   Demarest, Keith ^a   Lundeen, Scott ^a   Sui, Zhihua ^a  

^a Development LLC   (United States)

Author keywords

Antagonist; Glucocorticoid; In vitro; In vivo; oxa Steroid; Parallel synthesis; Progesterone; Receptor; SAR study

Indexed keywords

17 OXASTEROID DERIVATIVE; 4 FLUOROPHENYL OXASTEROID DERIVATIVE; 4 TRIFLUOROMETHYLPHENYL OXASTEROID DERIVATIVE; ANTIGESTAGEN; GLUCOCORTICOID ANTAGONIST; HETEROCYCLIC COMPOUND; PHENYL GROUP; STEROID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; COMPLEMENT C3; DRUG DESIGN; FEMALE; HUMANS; MIFEPRISTONE; MODELS, CHEMICAL; PROTEIN BINDING; RATS; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 33947731873     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.02.013     Document Type: Article

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