7-Aryl 1,5-dihydro-benzo[e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 13, 2008, Pages 6589-6600

  Zhang, Puwen ^a   Kern, Jeffrey C ^a   Terefenko, Eugene A ^a   Fensome, Andrew ^a   Unwalla, Ray ^a   Zhang, Zhiming ^a   Cohen, Jeffrey ^a   Berrodin, Thomas J ^a   Yudt, Matthew R ^a   Winneker, Richard C ^a   Wrobel, Jay ^a  

^a PFIZER INC   (United States)

Author keywords

Non steroidal PR modulators; PR agonists; PR antagonists; Progesterone receptor (PR)

Indexed keywords

3 (5 ETHYL 2 OXO 5 THIEN 3 YL 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL) 5 FLUOROBENZONITRILE; 3 (5 ETHYL 2 OXO 5 THIOPHEN 2 YL 1,2,3,5 TETRAHYDROBENZO[E][1,4]OXAZEPIN 7 YL) 5 FLUOROBENZONITRILE; 3 (5,5 DIMETHYL 2 OXO 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL) 5 FLUOROBENZONITRILE; 3 [5 ETHYL 5 (2 FURYL) 2 OXO 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL] 5 FLUOROBENZONITRILE; 3 [5,5 DI(2 FURYL) 2 OXO 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL] 5 FLUOROBENZONITRILE; 3 CHLORO 5 (5,5 DIMETHYL 2 OXO 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL)BENZONITRILE; 3 FLUORO 5 (2 OXO 5,5 DITHIEN 2 YL 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL)BENZONITRILE; 3 FLUORO 5 (5 ISOPROPYL 2 OXO 5 THIEN 2 YL 1,2,3,5 TETRAHYDRO 4,1 BENZOXAZEPIN 7 YL)BENZONITRILE; 7 (2 FLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (2,3 DIFLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5 ETHYL 5 (2 FURYL) 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5 ETHYL 5 THIEN 3 YL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(3H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5 ETHYL 5 THIOPHEN 2 YL 1,5 DIHYDROBENZO[E][1,4]OXAZEPIN 2 ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5 ISOPROPYL 5 THIEN 2 YL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(3H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5 METHYL 5 THIEN 2 YL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5 PROPYL 5 THIEN 2 YL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5,5 BIS(4 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5,5 DI(2 FURYL) 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5,5 DIPHENYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 4 FLUOROPHENYL) 5,5 DITHIEN 2 YL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 CHLORO 5 FLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3 FLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3,4 DIFLUOROPHENYL) 5 ETHYL 5 (2 FURYL) 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3,5 DICHLOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; 7 (3,5 DIFLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(3H) ONE; 7 (4 FLUOROPHENYL) 5,5 DIMETHYL 1,5 DIHYDRO 4,1 BENZOXAZEPIN 2(H) ONE; ANTIGESTAGEN; BENZOXAZINONE DERIVATIVE; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DECIDUALIZATION; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ALKALINE PHOSPHATASE; ANIMALS; BENZAZEPINES; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; HYDROXYLATION; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXAZEPINES; RECEPTORS, PROGESTERONE; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN ECHOVIRUS 1; RATTUS;

EID: 44849103124     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.018     Document Type: Article

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