Suppression of neuro-inflammatory signaling cascade by tocotrienol can prevent chronic alcohol-induced cognitive dysfunction in rats

Behavioural Brain Research

Volumn 203, Issue 2, 2009, Pages 296-303

  Tiwari, Vinod ^a   Kuhad, Anurag ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Acetylcholinesterase; Alcohol; Cognitive deficits; IL 1 ; Oxidative nitrosative stress; TNF ; Tocotrienol; Vitamin E

Indexed keywords

ACETYLCHOLINESTERASE; ALCOHOL; ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN CORTEX; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; HIPPOCAMPUS; INFLAMMATION; LATENT PERIOD; MALE; MAZE TEST; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIMARY PREVENTION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACETYLCHOLINESTERASE; ALCOHOL AMNESTIC DISORDER; ALPHA-TOCOPHEROL; ANIMALS; CEREBRAL CORTEX; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; INTERLEUKIN-1BETA; LIPID PEROXIDATION; MALE; MAZE LEARNING; MEMORY; MOTOR ACTIVITY; NITRITES; OXIDATIVE STRESS; RATS; RATS, WISTAR; TOCOTRIENOLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67649641781     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2009.05.016     Document Type: Article

References (64)

1. Ahn K.S., Sethi G., Krishnan K., and Aggarwal B.B. Gamma-tocotrienol inhibits nuclear factor kappa B signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 282 (2007) 809-820
2. Basheer R., Rainnie D.G., Porkka-Heiskanen T., Ramesh V., and McCarley R.W. Adenosine, prolonged wakefulness, and A1-activated NF-kappaB DNA binding in the basal forebrain of the rat. Neuroscience 104 (2001) 731-739
3. Behl C., and Moosmann B. Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds. Biol Chem 383 (2002) 521-536
4. Burton G.W., and Ingold K.U. Vitamin E as an in vitro and in vivo antioxidant. Ann N Y Acad Sci 570 (1989) 7-22
5. Butterfield D.A., Castegna A., Drake J., Scapagnini G., and Calabrese V. Vitamin E and neurodegenerative disorders associated with oxidative stress. Nutr Neurosci 5 (2002) 229-239
6. Chen N., Ma W., Huang C., and Dong Z. Translocation of protein kinase C epsilon and protein kinase C delta to membrane is required for ultraviolet B-induced activation of mitogen-activated protein kinases and apoptosis. J Biol Chem 274 (1999) 15389-15394
7. Claiborne A. Catalase activity. In: Greenwald R.A. (Ed). Handbook of methods for oxygen radical research (1985), CRC, Boca Raton 283-284
8. Coe I.R., Yao L., Diamond I., and Gordon A.S. The role of protein kinase C in cellular tolerance to ethanol. J Biol Chem 271 (1996) 29468-29472
9. Collins M.A., Zou J.Y., and Neafsey E.J. Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism. FASEB J 12 2 (1998) 221-230
10. Crews F.T., Buckley T., Dodd P.R., Ende G., Foley N., Harper C., et al. Alcoholic neurobiology: changes in dependence and recovery. Alcohol Clin Exp Res 29 (2005) 1504-1513
11. Crews F.T., Collins M.A., Dlugos C., Littleton J., Wilkins L., Neafsey E.J., et al. Alcohol induced neurodegeneration: when, where and why?. Alcohol Clin Exp Res 28 (2004) 350-364
12. Crews F., Nixon K., Kim D., Joseph J., Shukitt-Hale B., Qin L., et al. BHT blocks NF-kB activation and ethanol-induced brain damage. Alcohol Clin Exp Res 30 11 (2006) 1938-1949
13. Cross T.G., Scheel-Toellner D., Henriquez N.V., Deacon E., Salmon M., and Lord J.M. Serine/threonine protein kinases and apoptosis. Exp Cell Res 256 (2000) 34-41
14. Cumiskey D., Butler M.P., Moynagh P.N., and O'connor J.J. Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor alpha on long-term potentiation. Brain Res 1136 (2007) 13-19
15. Dicker E., and Cederbaum A.I. Increased NADH-dependent production of reactive oxygen intermediates by microsomes after chronic ethanol consumption: comparisons with NADPH. Arch Biochem Biophys 293 (1992) 274-280
16. Eckardt M.J., and Martin P.R. Clinical assessment of cognition in alcoholism. Alcohol Clin Exp Res 10 (1986) 123-127
17. Ellman G.L., Courtney D.K., Andres V., and Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7 (1961) 88-95
18. Gordon A.S., Yao L., Wu Z.L., Coe I.R., and Diamond I. Ethanol alters the subcellular localization of delta- and epsilon protein kinase C in NG108-15 cells. Mol Pharmacol 52 (1997) 554-559
19. 15N] nitrate in biological fluids. Anal Biochem 126 (1982) 131-138
20. Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem 59 (1992) 1609-1623
21. Hamelink C., Hampson A., Wink D.A., Eiden L.E., and Eskay R.L. Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity. J Pharmacol Exp Ther 314 (2005) 780-788
22. Herrera D.G., Yague A.G., Johnsen-Soriano S., Bosch-Morell F., Collado-Morente L., Muriach M., et al. Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant. Proc Natl Acad Sci USA 100 (2003) 7919-7924
23. Iliev A., Traykov V., Prodanov D., Mantchev G., Yakimova K., Krushkov I., et al. Effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit. Methods Find Exp Clin Pharmacol 21 4 (1999) 297-301
24. Jha S., and Patel R. Some observations on the spectrum of dementia. Neurol India 52 (2004) 213-214
25. Jollow D.J., Mitchell J.R., Zampaglione N., and Gillette J.R. Bromobenze induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzenoxide as the hepatotoxic intermediate. Pharmacology 11 (1974) 151-169
26. Jung M.E., Gatch M.B., and Simpkins J.W. Estrogen neuroprotection against the neurotoxic effects of ethanol withdrawal: potential mechanisms. Exp Biol Med (Maywood) 230 1 (2005) 8-22
27. Kasdallah-Grissa A., Mornagui B., Aouani E., Hammami M., Gharbi N., Kamoun A., et al. Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol Alcohol 41 3 (2006) 236-239
28. Kessler R.C., McGonagle K.A., Zhao S., Nelson C.B., Hughes M., Eschleman S., et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the national comorbidity survey. Arch Gen Psychiatry 51 (1994) 8-19
29. Khalil R., King M.A., and Soliman M.R. Testosterone reverses ethanol-induced deficit in spatial reference memory in castrated rats. Pharmacology 75 2 (2005) 87-92
30. Khanna S., Roy S., Ryu H., Bahadduri P., Swaan P.W., Ratan R.R., et al. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 278 44 (2003) 43508-43515
31. Kono H., Rusyn I., Bradford B.U., Connor H.D., Mason R.P., and Thurman R.G. Allopurinol prevents early alcohol-induced liver injury in rats. J Pharmacol Exp Ther 293 (2000) 296-303
32. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186 (1978) 189-195
33. Kuhad A., Bishnoi M., Tiwari V., and Chopra K. Suppression of NF-κβ signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol Biochem Behav 92 2 (2009) 251-259
34. Kuhad A., and Chopra K. Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. Eur J Pharmacol 576 (2007) 34-42
35. Kukielka E., Dicker E., and Cederbaum A.I. Increased production of reactive oxygen species by rat liver mitochondria after chronic ethanol treatment. Arch Biochem Biophys 309 (1994) 377-386
36. Kumar V.M.H., and Gupta Y.K. Intracerebroventricular administration of colchicine produces cognitive impairment associated with oxidative stress in rats. Pharmacol Biochem Behav 73 3 (2002) 565-571
37. Maher P. How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J Neurosci 21 (2001) 2929-2938
38. Mansouri A., Demeilliers C., Amsellem S., Pessayre D., and Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther 298 (2001) 737-743
39. Mantle D., and Preedy V.R. Free radicals as mediators of alcohol toxicity. Adverse Drug React Toxicol Rev 18 (1999) 235-252
40. Messing R.O., Petersen P.J., and Henrich C.J. Chronic ethanol exposure increases levels of protein kinase C delta and epsilon and protein kinase C-mediated phosphorylation in cultured neural cells. J Biol Chem 266 (1991) 23428-23432
41. Montoliu C., Valles S., Renau-Piqueras J., and Guerri C. Ethanol induced oxygen radical formation and lipid peroxidation in rat brain: effect of chronic alcohol consumption. J Neurochem 63 (1994) 1855-1862
42. Morris R.G., Garrud P., Rawlins J.N., and O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 297 (1982) 681-683
43. Murray J., Taylor S.W., Zhang B., and Ghosh S. Oxidative damage to mitochondrial complex I due to peroxynitrite. J Biol Chem 278 (2003) 37223-37230
44. Nordmann R., Ribiere C., and Rouach H. Ethanol-induced lipid peroxidation and oxidative stress in extrahepatic tissues. Alcohol Alcohol 25 (1990) 231-237
45. Osakada F., Hashino A., Kume T., Katsuki H., Kaneko S., and Akaike A. Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons. Neuropharmacology 47 (2004) 904-915
46. Pearce B.C., Parker R.A., Deason M.E., Dischino D.D., Gillespie E., Qureshi A.A., et al. Inhibitors of cholesterol biosynthesis. 2. Hypocholesterolemic and antioxidant activities of benzopyran and tetrahydronaphthalene analogues of the tocotrienols. J Med Chem 37 4 (1994) 526-541
47. Pfefferbaum A., Sullivan E.V., Rosenbloom M.J., Mathalon D.H., and Lim K.O. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Arch Gen Psychiatry 55 (1998) 905-912
48. Qin L., He J., Hanes R.N., Pluzarev O., Hong J.S., and Crews F.T. Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment. J Neuroinflammation 5 (2008) 10
49. Reddy S.K., Husain K., Schlorff E.C., Scott R.B., and Somani S.M. Dose response of ethanol ingestion on antioxidant defense system in rat brain subcellular fractions. Neurotoxicology 20 (1999) 977-987
50. Rico E.P., Rosemberg D.B., Dias R.D., Bogo M.R., and Bonan C.D. Ethanol alters acetylcholinesterase activity and gene expression in zebrafish brain. Toxicol Lett 174 1-3 (2007) 25-30
51. Sen C.K., Khanna S., and Roy S. Tocotrienols: vitamin E beyond tocopherols. Life Sci 78 18 (2006) 2088-2098
52. Sen C.K., Khanna S., Roy S., and Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem 275 17 (2000) 13049-13055
53. Serbinova E., Kagan V., Han D., and Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med 10 5 (1991) 263-275
54. Serbinova E.A., and Packer L. Antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Methods Enzymol 234 (1994) 354-366
55. Sharma M., and Gupta Y.K. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci 71 21 (2002) 2489-2498
56. Sharma M., and Gupta Y.K. Effect of chronic treatment of melatonin on learning, memory and oxidative deficiencies induced by intracerebroventricular streptozotocin in rats. Pharmacol Biochem Behav 70 2-3 (2001) 325-331
57. Siebenlist U., Brown K., and Franzoso G. NF-kB: a mediator of pathogen and stress responses. In: Bauerele P.A. (Ed). Inducible gene expression (1995), Birkhauser, Boston 135-147
58. Suzuki Y.J., Tsuchiya M., Wassall S.R., Choo Y.M., Govil G., Kagan V.E., et al. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32 40 (1993) 10692-10699
59. Tuzcu M., and Baydas G. Effect of melatonin and vitamin E on diabetes-induced learning and memory impairment in rats. Eur J Pharmacol 537 (2006) 106-110
60. Valles S.L., Blanco A.M., Pascual M., and Guerri C. Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol 14 4 (2004) 365-371
61. White A.M. What happened? Alcohol, memory blackouts and the brain. Alcohol Res Health 27 (2003) 186-196
62. Wills E.D. Mechanism of lipid peroxide formation in animals. Biochem J 99 (1965) 667-676
63. Zima T., Fialova L., Mestek O., Janebova M., Crkovska J., Malbohan I., et al. Oxidative stress, metabolism of ethanol and alcohol-related diseases. J Biomed Sci 8 (2001) 59-70
64. Zou J.Y., and Crews F.T. TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition. Brain Res 1034 (2005) 11-24