Evaluation of protective effect of multi-epitope DNA vaccine encoding six antigen segments of Toxoplasma gondii in mice

Parasitology Research

Volumn 105, Issue 1, 2009, Pages 267-274

  Liu, Shan ^a   Shi, Lin ^a   Cheng, Yan Bin ^a   Fan, Gui Xiang ^a   Ren, Hui Xun ^a   Yuan, Yu Kang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; DNA VACCINE; GAMMA INTERFERON;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SURVIVAL RATE; TACHYZOITE; TH1 CELL; TOXOPLASMA GONDII; TOXOPLASMOSIS; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CELL PROLIFERATION; CYTOKINES; EPITOPES; GENETIC VECTORS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; PLASMIDS; PROTOZOAN VACCINES; SURVIVAL ANALYSIS; T-LYMPHOCYTES; TOXOPLASMA; TOXOPLASMOSIS; VACCINES, DNA;

EUKARYOTA; MUS; TOXOPLASMA GONDII;

EID: 67649625125     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-009-1393-1     Document Type: Article

References (44)

1. F Alberto R Alexandro O Sergio 2003 Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice Vaccine 21 1327 1335 (Pubitemid 36266690)
2. AJP Alix 2000 Predictive estimation of protein linear epitopes by using the program PEOPLE Vaccine 18 311 314
3. CW Angus D Klivington-Evans JP Dubey JA Kovacs 2000 Immunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents J Infect Dis 181 317 324 (Pubitemid 30049063)
4. D Askew RS Chu AM Krieg CV Harding 2000 CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms J Immunol 165 6889 6895 (Pubitemid 32001158)
5. ZK Ballas WL Rasmussen AM Krieg 1996 Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA J Immunol 157 1840 1845 (Pubitemid 126449654)
6. E Beghetto A Pucci O Minenkova A Spadoni L Bruno W Buffolano D Soldati F Felici N Gargano 2001 Identification of a human immunodominant B-cell epitope within the GRA1 antigen of Toxoplasma gondii by phage display of cDNA libraries Int J Parasitol 31 1659 1668 (Pubitemid 33152821)
7. MW Black JC Boothroyd 2000 Lytic cycle of Toxoplasma gondii Microbiol Mol Biol Rev 64 607 623
8. D Buxton 1998 Protozoan infections (Toxoplasma gondii, Neospora caninum and Sarcocystis spp.) in sheep and goats: recent advances Vet Res 29 289 310 (Pubitemid 28293469)
9. D Buxton EA Innes 1995 A commercial vaccine for ovine toxoplasmosis Parasitology 110 11 16
10. D Buxton K Thomson S Maley S Wright HJ Bos 1991 Vaccination of sheep with a live incomplete strain (S48) of Toxoplasma gondii and their immunity to challenge when pregnant Vet Rec 129 89 93
11. MF Cesbron-Delauw C Boutillon C Mercier MP Fourmaux A Murray F Miquey A Tartar A Capron 1992 Amino acid sequence requirements for the epitope recognized by a monoclonal antibody reacting with the secreted antigen GP28.5 of Toxoplasma gondii Mol Immunol 29 1375 1382
12. T Chardès F Velge-Roussel P Mevelec MN Mevelec D Buzoni-Gatel D Bout 1993 Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice Immunology 78 421 429 (Pubitemid 23076238)
13. RS Chu OS Targoni AM Krieg PV Lehmann CV Harding 1997 CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity J Exp Med 186 1623 1631 (Pubitemid 27506276)
14. HL Davis R Weeratna TJ Waldschmidt L Tygrett J Schorr AM Krieg 1998 CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen J Immunol 160 870 876 (Pubitemid 28049329)
15. D Dory V Béven AM Torché S Bougeard R Cariolet A Jestin 2005 CpG motif in ATCGAT hexamer improves DNA-vaccine efficiency against lethal Pseudorabies virus infection in pigs Vaccine 23 4532 4540 (Pubitemid 40967982)
16. JP Dubey DE Hill JL Jones 2005 Prevalence of viable Toxoplasma gondii in beef, chicken, and pork from retail meat stores in the United States: risk assessment to consumers J Parasitol 91 1082 1093 (Pubitemid 41735028)
17. V Duquesne C Auriault H Gras-Masse C Boutillon F Darcy MF Cesbron-Delauw A Tartar A Capron 1991 Identification of T cell epitopes within a 23-kD antigen (P24) of Toxoplasma gondii Clin Exp Immunol 84 527 534
18. A Fachado A Rodriguez SO Angel DC Pinto I Vila A Acosta RR Amendoeira J Lannes-Vieira 2003 Protective effect of a naked DNA vaccine cocktail against lethal toxoplasmosis in mice Vaccine 21 1327 1335 (Pubitemid 36266690)
19. I Godard J Estaquier L Zenner M Bossus C Auriault F Darcy H Gras-Masse A Capron 1994 Antigenicity and immunogenicity of P30-derived peptides in experimental models of toxoplasmosis Mol Immunol 31 1353 1363 (Pubitemid 24355148)
20. G Hartmann GJ Weiner AM Krieg 1999 A potent signal for growth activation and maturation of human dendritic cells Proc Natl Acad Sci U S A 96 9305 9310 (Pubitemid 29374750)
21. H Hemmi O Takeuchi T Kawai 2000 A toll-like receptor recognizes bacterial DNA Nature 408 740 745 (Pubitemid 32015992)
22. C Ivory K Chadee 2004 DNA vaccines: designing strategies against parasitic infections Genet Vaccines Ther 2 17 25 (Pubitemid 40471993)
23. H Kang JS Remington Y Suzuki 2000 Decreased resistance of B cell deficient mice to infection with T. gondii despite unimpaired expression of IFN-gamma, TNF-alfa and inducible nitric oxide synthase J Immunol 164 2629 2634 (Pubitemid 30115494)
24. NJ Kennedy TW Spithill J Tennent PR Wood D Piedrafita 2006 DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy Vaccine 24 970 979 (Pubitemid 43185315)
25. DM Klinman G Yamshchikov Y Ishigatsubo 1997 Contribution of CpG motifs to the immunogenicity of DNA vaccines J Immunol 158 3635 3639 (Pubitemid 127488716)
26. DM Klinman D Currie I Gursel D Verthelyi 2004 Use of CpG oligodeoxynucleotides as immune adjuvants Immunol Rev 199 201 216 (Pubitemid 38736773)
27. Y Kojima KQ Xin T Ooki 2002 Adjuvant effect of multi-CpG motifs on an HIV-1 DNA vaccine Vaccine 20 2857 2865
28. JD Kravetz DG Federman 2005 Toxoplasmosis in pregnancy Am J Med 118 212 216 (Pubitemid 40312628)
29. AM Krieg AK Yi S Matson TJ Waldschmidt GA Bishop R Teasdale GA Koretzky DM Klinman 1995 CpG motifs in bacterial DNA trigger direct B-cell activation Nature 374 546 549
30. H Kringel JP Dubey E Beshah R Hecker JF Urban Jr 2004 CpG-oligodeoxynucleotides enhance porcine immunity to Toxoplasma gondii Vet Parasitol 123 55 66 (Pubitemid 38950892)
31. GB Lipford M Bauer C Blank R Reiter H Wagner K Heeg 1997 CpG-containing synthetic oligodeoxynucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants Eur J Immunol 27 2340 2344 (Pubitemid 27404319)
32. BG Meerburg JW Van Riel JB Cornelissen A Kijlstra MF Mul 2006 Cats and goat whey associated with Toxoplasma gondii infection in pigs Vector Borne Zoonotic Dis 6 266 274
33. R Meisel S Stachelhaus MN Mévélec G Reichmann JF Dubremetz HG Fischer 1996 Identification of two alleles in the GRA4 locus of Toxoplasma gondii determining a differential epitope which allows discrimination of type I versus type II and III strains Mol Biochem Parasitol 81 259 263 (Pubitemid 26316568)
34. MN Mévélec O Mercereau-Puijalon D Buzoni-Gatel I Bourguin T Chardès JF Dubremetz D Bout 1998 Mapping of B epitopes in GRA4, a dense granule antigen of Toxoplasma gondii and protection studies using recombinant proteins administered by the oral route Parasite Immunol 20 183 195 (Pubitemid 28221673)
35. A Murray C Mercier A Decoster L Lecordier A Capron MF Cesbron-Delauw 1993 Multiple B-cell epitopes in a recombinant GRA2 secreted antigen of Toxoplasma gondii Appl Parasitol 34 235 244
36. G Mutwiri R Pontarollo S Babiuk 2003 Biological activity of immunostimulatory CpG DNA motifs in domestic animals Vet Immunol Immunopathol 91 89 103 (Pubitemid 36113256)
37. M Roman E Martin-Orozco JS Goodman MD Nguyen Y Sato A Ronaghy RS Kornbluth DD Richman DA Carson E Raz 1997 Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants Nat Med 3 849 854 (Pubitemid 27353443)
38. Y Sato M Roman H Tighe D Lee M Corr MD Nguyen GJ Silverman M Lotz DA Carson E Raz 1996 Immunostimulatory DNA sequences necessary for effective intradermal gene immunization Science 273 352 354 (Pubitemid 26250262)
39. S Scheiblhofer R Weiss H Dürnberger S Mostböck M Breitenbach I Livey J Thalhamer 2003 A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses Microbes Infect 5 939 946 (Pubitemid 36986569)
40. H Siachoque F Guzman J Burgos ME Patarroyo JE Gomez Marin 2006 Toxoplasma gondii: immunogenicity and protection by P30 peptides in a murine model Exp Parasitol 114 62 65 (Pubitemid 44188651)
41. LD Sibley LB Adams JL Krahenbuhl 1993 Macrophage interactions in toxoplasmosis Res Immunol 144 38 40 (Pubitemid 23064899)
42. F Velge-Roussel T Chardès P Mévélec M Brillard J Hoebeke D Bout 1994 Epitopic analysis of the Toxoplasma gondii major surface antigen SAG1 Mol Biochem Parasitol 66 31 38 (Pubitemid 24250050)
43. AN Vermeulen 1998 Progress in recombinant vaccine development against coccidiosis. A review and prospects into the next millennium Int J Parasitol 28 1121 1130 (Pubitemid 28364740)
44. R Weeratna CL Brazolot Millan AM Krieg HL Davis 1998 Reduction of antigen expression from DNA vaccines by coadministered oligodeoxynucleotides Antisense Nucleic Acid Drug Dev 8 351 356 (Pubitemid 28446121)