Membrane attachment facilitates ligand access to the active site in monoamine oxidase A

Biochemistry

Volumn 48, Issue 25, 2009, Pages 5864-5873

  Apostolov, Rossen ^a   Yonezawa, Yasushige ^a   Standley, Daron M ^a   Kikugawa, Gota ^b   Takano, Yu ^a   Nakamura, Haruki ^a  

^a OSAKA UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CENTRAL NERVOUS SYSTEMS; CONFORMATIONAL CHANGE; DOMINANT MODE; FREEFORMS; GLOBAL DYNAMICS; INTER-DOMAIN; MEMBRANE ENZYMES; MEMBRANE-BOUND; MOLECULAR DYNAMICS SIMULATIONS; MONOAMINE OXIDASE; MONOAMINE OXIDASE A; MUTATIONAL ANALYSIS; PRODUCT RELEASE; SUBSTRATE UPTAKE;

DYNAMICS; ENZYME ACTIVITY; ENZYMES; MEMBRANES; MOLECULAR DYNAMICS; PRINCIPAL COMPONENT ANALYSIS; SUBSTRATES;

CELL MEMBRANES;

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME RELEASE; ENZYME STABILITY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CELL MEMBRANE; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; EXTRACELLULAR SPACE; HUMANS; ISOENZYMES; LIGANDS; MOLECULAR SEQUENCE DATA; MONOAMINE OXIDASE; RATS; THERMODYNAMICS;

RATTUS;

EID: 67649610423     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900493n     Document Type: Article

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