'Decoy peptide' region (RIFLKRMPSI) of prorenin prosegment plays a crucial role in prorenin binding to the (pro)renin receptor

International Journal of Molecular Medicine

Volumn 24, Issue 1, 2009, Pages 83-89

  Nabi, A H M Nurun ^a   Biswas, Kazal Boron ^a   Nakagawa, Tsutomu ^a   Ichihara, Atsuhiro ^b   Inagami, Tadashi ^c   Suzuki, Fumiaki ^a  

^a GIFU UNIVERSITY   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

'Handle' region peptide; (P)RR blocker; (Pro)renin receptor; Decoy peptide; Prorenin; Renin

Indexed keywords

PRORENIN; RECEPTOR ANTIBODY; RECEPTOR PROTEIN; RENIN ANTIBODY; RENIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY LABELING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; RECEPTOR BINDING; STEADY STATE; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CELL LINE; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RENIN; SURFACE PLASMON RESONANCE;

EID: 67649534504     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000210     Document Type: Article

References (27)

1. Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T and Sraer JD: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109: 1417-1427, 2002.
2. Nabi AHMN, Uddin NM, Nakagawa T, Iwata H, Ichihara A, Inagami T and Suzuki F: Role of 'handle' region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci 12: 4810-4817, 2007.
3. Batenburg WW, Krop M, Garrelds IM, de Vries R, de Bruin RJ, Burcklé CA, Müller DN, Bader M, Nguyen G and Danser AH: Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens 25: 2441-2453, 2007.
4. Nabi AHMN, Kageshima A, Uddin MN, Nakagawa T, Park EY and Suzuki F: Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 18: 483-488, 2006.
5. Satofuka S, Ichihara A, Nagai N, Tsubota K, Itoh H and Ishida S: Pathologic roles of prorenin and (pro)renin receptor in the eye. Front Biosci 13: 3884-3895, 2008.
6. Shan Z, Cuadra AE, Sumners C and Raizada MK: Characterization of a functional (pro)renin receptor in rat brain neurons. Exp Physiol 93: 701-708, 2008.
7. Sakoda M, Ichihara A, Kaneshiro Y, Takemitsu T, Nakazato Y, Nabi AHMN, Nakagawa T, Suzuki F, Inagami T and Itoh H: (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hypertens Res 30: 1139-1146, 2007.
8. Saris J, 't Hoen P, Garrelds I, Dekkers D, denDunnen J, Lamers J and Danser AHJ: Prorenin induces intracellular signaling in cardiomyocytes of angiotensin II. Hypertension 48: 564-571, 2006.
9. Nguyen G and Danser AHJ: Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. Exp Physiol 93: 557-563, 2008.
10. Kaneshiro Y, Ichihara A, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Hayashi M and Inagami T: Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. Kidney Int 70: 641-646, 2006.
11. Campbell DJ: Critical review of prorenin and (pro)renin receptor research. Hypertension 51: 1259-1264, 2008.
12. Ichihara A, Sakoda M, Kurauchi-Mito A, Kaneshiro Y and Itoh H: Involvement of (pro)renin receptor in the glomerular filtration barrier. J Mol Med 86: 629-635, 2008.
13. Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, Nabi AHMN, Nishiyama A, Sugaya T, Hayashi M and Inagami T: Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol 17: 1950-1961, 2006.
14. Suzuki F, Hayakawa M, Nakagawa T, Nasir UM, Ebihara A, Iwasawa A, Ishida Y, Nakamura Y and Murakami K: Human prorenin has 'gate and handle' regions for its non-proteolytic activation. J Biol Chem 278: 22217-22222, 2003.
15. Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AHMN, Ishida Y, Inagami T and Saruta T: Inhibition of diabetic nephropathy by a decoy peptide corresponding to the 'handle' region for nonproteolytic activation of prorenin. J Clin Invest 114: 1128-1135, 2004.
16. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Nakagawa T, Nishiyama A, Kawachi H, Shimizu F and Inagami T: Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17: 2495-2503, 2006.
17. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Nishiyama A, Inagami T and Hayashi M: Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47: 894-900, 2006.
18. Susic D, Zhou X, Frohlich ED, Lippton H and Knight M: Cardiovascular effects of prorenin blockade in genetically hypertensive rats (SHR) on normal and high salt diet. Am J Physiol Heart Circ Physiol 295: H1117-H1121, 2008.
19. Veniant M, Ménard J, Bruneval P, Morley S, Gonzalez MF and Mullins J: Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 98: 1966-1970, 1996.
20. Deinum J, Ronn B, Mathieson E, Derky FHM, Hop WCJ and Schalenkamp MADH: Increase in serum prorenin precedes onset of microbalbuminuria in patients with insulin dependent diabetes mellitus. Diabetologia 42: 1006-1010, 1999.
21. Deinum J and Danser AHJ: Renin, prorenin and putative (pro)renin receptor. Hypertension 46: 1069-1076, 2005.
22. Poorman RA, Palermo DP, Post LE, Murakami K, Kinner JH, Smith CW, Reardon I and Heinrikson RL: Isolation and characterization of native human renin derived from Chinese hamster ovary cells. Proteins 1: 139-145, 1986.
23. Nakagawa T, Nishiuchi K, Akaki J, Iwata H, Satou R, Suzuki F and Nakamura Y: Efficient production of recombinant human (pro)renin utilizing a decahistidine tag attached at the C-terminus. Biosci Biotechnol Biochem 71: 256-260, 2007.
24. Feldt S, Batenburg WW, Mazak I, Maschke U, Wellner M, Kvakan H, Dechend R, Fiebeler A, Burckle C, Contrepas A, Jan Danser AH, Bader M, Nguyen G, Luft FC and Muller DN: Prorenin and renin-induced extracellular signal-regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 51: 682-688, 2008.
25. Feldt S, Maschke U, Dechend R, Luft FC and Muller DN: The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling. J Am Soc Nephrol 19: 743-748, 2008.
26. Muller DN, Klanke B, Feldt S, Cordasic N, Hartner A, Schmieder RE, Luft FC and Hilgers KF: (Pro)renin receptor peptide inhibitor 'handle-region' peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. Hypertension 51: 676-681, 2008.
27. Kato T, Kageshima A, Suzuki F and Park EY: Expression and purification of human (pro)renin receptor in insect cells using baculovirus expression system. Protein Expr Purif 58: 242-248, 2008.