Statins inhibit NK-cell cytotoxicity by interfering with LFA-1-mediated conjugate formation

European Journal of Immunology

Volumn 39, Issue 6, 2009, Pages 1456-1465

  Raemer, Patrick C ^a   Kohl, Kristine ^a   Watzl, Carsten ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adhesion molecules; Cytotoxicity; Human; NK cells

Indexed keywords

CALCIUM ION; CHOLESTEROL; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOMODULATING AGENT; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MEVINOLIN; PRAVASTATIN; SIMVASTATIN; GERANYLGERANYL PYROPHOSPHATE; INTERCELLULAR ADHESION MOLECULE 1; ISOPRENOID PHOSPHATE; MEVALONIC ACID; NATURAL KILLER CELL RECEPTOR; PHOSPHOLIPASE C GAMMA;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; CELL ADHESION; CELL POLARITY; CEREBROVASCULAR DISEASE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; EFFECTOR CELL; HUMAN; HUMAN CELL; HYPERCHOLESTEROLEMIA; ISOPRENYLATION; NATURAL KILLER CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TARGET CELL; CALCIUM SIGNALING; CELL COMMUNICATION; CELL STRAIN K 562; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PRENYLATION; PROTEIN BINDING; TUMOR CELL LINE;

CALCIUM SIGNALING; CELL ADHESION; CELL COMMUNICATION; CELL DEGRANULATION; CELL LINE, TUMOR; CELL POLARITY; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERCELLULAR ADHESION MOLECULE-1; K562 CELLS; KILLER CELLS, NATURAL; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEVALONIC ACID; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; POLYISOPRENYL PHOSPHATES; PRENYLATION; PROTEIN BINDING; RECEPTORS, NATURAL KILLER CELL;

EID: 67649531394     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838863     Document Type: Article

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